Results 81 to 90 of about 86,596 (332)

Solvent‐ and Energy‐Free Solid‐State Strategy for Enzyme Encapsulation in ZIF

Angewandte Chemie, EarlyView.
A solvent‐ and energy‐free solid‐state strategy is developed for synthesizing enzyme@ZIF biocomposites by directly mixing enzymes with ZIF precursors. Driven by acid–base interactions, the resulting biocomposites show enhanced activity due to multiphase crystalline structure, larger surface area, better electron transfer, and favorable enzyme ...
Zefang Yu, Bernt Johannessen, Ming Zhang, Hongyu Shi, Yanhan Wang, Yu Wang, Jun Ge, Kang Liang, Jieying Liang   +8 more
wiley   +2 more sources

Changes in lipids and medium- and long-chain fatty acids during the spontaneous fermentation of ripened pu-erh tea

Current Research in Food Science
During the fermentation of ripened pu-erh tea (RPT), the composition of lipids and other compounds changes significantly. In this study, we conducted industrial fermentation of RPT and observed that the levels of water extract, tea polyphenols, free ...
Qiu-yue Chen, Ming-li Liu, Ruo-yu Li, Bin Jiang, Kun-yi Liu, Yan-qin Xiao, Qi Wang, Teng Wang, Lian-qin Zhao, Wei-tao Wang, Zhi-wei Liu, Li-jiao Chen, Yan Ma, Ming Zhao   +13 more
doaj   +1 more source

Decoupling Electron and Proton Transfer in Noncontact Catalytic Hydrogenation of Nitroaromatics

Advanced Science, EarlyView.
A noncontact catalytic system is constructed by modifying metal nanoparticles supported on conductive carbon with (hypo)phosphorous acid. This design effectively prevents the adsorption of unsaturated substrates while permitting H2 activation to generate electrons and protons. The hydrogenation is governed by electron transfer processes, which occur at
Zhongyin Liang, Qingyuan Wu, Zhe Yang, Nanfeng Zheng   +3 more
wiley   +1 more source

Model‐Guided Systematic Metabolic Engineering for Enhanced Spinosad Biosynthesis in Saccharopolyspora spinosa NHF132

Advanced Science, EarlyView.
A genome‐scale model guided the systematic metabolic engineering of Saccharopolyspora spinosa, enabling a 5.5‐fold boost in the green bioinsecticide spinosad to 1.8 g L−1 and establishing an actinomycete framework for complex natural products overproduction.
Shuliu Wang, Yuxin Liu, Qian Zhang, Yue Jiang, Xiaoqian Zeng, Chengyu Zhang, Jiagao Cheng, Weishan Wang, Lixin Zhang, Gao‐Yi Tan   +9 more
wiley   +1 more source

Amide and Thioester Synthesis Via Oxidative Coupling of Alcohols with Amines or Thiols Using Alcohol Dehydrogenases

Angewandte Chemie, EarlyView.
Alcohol dehydrogenases (ADHs) are best known for reducing ketones to chiral alcohols, but their oxidative potential is rarely exploited. Here, we show that selected ADHs catalyze newly discovered promiscuous transformations: the oxidative coupling of primary alcohols with amines or thiols, enabling the direct and efficient synthesis of a broad range of
Matteo Damian, Vasilis Tseliou, Patrick Peters, Tanja Knaus, Francesco G. Mutti   +4 more
wiley   +2 more sources

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR‐δ Signaling Pathway

Advanced Science, EarlyView.
Utilizing PDO, cell lines and cervical cancer xenograft (CDX) models, the study demonstrate both in vitro and in vivo that the metabolite of L. crispatus, erucic acid, can modulate the proliferation, migration and invasion of cervical cancer by activating the PPAR‐δ pathway.
Qianwei Zhen, Yuexuan Xu, Ying Xu, Xiao Liu, Yuting Zhang, Dan Ye, Sai Han, Shili Liu, Youzhong Zhang   +8 more
wiley   +1 more source

Three‐Segment Protein Labeling Using a Highly Efficient and Cysteine‐Less Split Intein Identified with Computational Prediction of Aggregation Properties

Angewandte Chemie, EarlyView.
Tandem protein trans‐splicing (PTS) assembles a protein from three segments. Expanding this technology to individually treat cysteines in each segment, for example, for chemical labeling using thiol bioconjugation, the authors identify a second, highly efficient cysteine‐less split intein.
Christoph Humberg, Jonas Kröger, Shmuel Pietrokovski, Henning D. Mootz   +3 more
wiley   +2 more sources

ARL5B Drives Esophageal Squamous Cell Carcinoma Progression via ROCK1–SREBP1‐Mediated Lipid Metabolic Reprogramming

Advanced Science, EarlyView.
Esophageal squamous cell carcinoma urgently requires new therapeutic strategies. Adenosine diphosphate‐ribosylation factor‐like protein 5B (ARL5B) is identified as a novel oncogene that remodels fatty acid metabolism through the ras homologous‐associated coiled‐coil containing protein kinase 1 (ROCK1)–sterol regulatory element‐binding protein 1 (SREBP1)
Xinyue Ma, Yanfei Sun, Hongyuan Mao, Chenhan Huang, Zerun Li, Tianzi Wang, Dizhi Jiang, Xinyu Zhang, Zhenyu Yuan, Zhihui Zhang, Bo Cheng, Ruiqing Wang, Yufeng Cheng   +12 more
wiley   +1 more source

ZDHHC2‐Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation

Advanced Science, EarlyView.
Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin   +10 more
wiley   +1 more source

A Hexadecacationic Metal–Organic Cage for Anchoring Sulfonates: High‐Order Binding of Di‐ and Trisulfonates and High‐Performance Removal of Perfluorosulfonates from Water

Advanced Science, EarlyView.
Developing synthetic hosts that can bind sulfonate anions or sequester perfluorosulfonates is crucial in biological and environmental sciences. Here, a Zr‐based metal–organic cage (1) integrating electron‐deficient tripyridinium panels is designed and synthesized.
Yawei Liu, Gen Li, Xiang Zhang, Zelin Du, Tingting Zhang, Yongya Zhang, Roy Lavendomme, En‐Qing Gao, Dawei Zhang   +8 more
wiley   +1 more source