Results 1 to 10 of about 410,264 (377)

T cell subtype profiling measures exhaustion and predicts anti-PD-1 response

Scientific Reports, 2022
Anti-PD-1 therapy can provide long, durable benefit to a fraction of patients. The on-label PD-L1 test, however, does not accurately predict response.
Ian Schillebeeckx, Jon Earls, Kevin C. Flanagan, Jeffrey Hiken, Alex Bode, Jon R. Armstrong, David N. Messina, Douglas Adkins, Jessica Ley, Ilaria Alborelli, Philip Jermann, Jarret I. Glasscock   +11 more
doaj   +1 more source

Biological Catalysis and Information Storage Have Relied on N-Glycosyl Derivatives of β-D-Ribofuranose since the Origins of Life

Biomolecules, 2023
Most naturally occurring nucleotides and nucleosides are N-glycosyl derivatives of β-d-ribose. These N-ribosides are involved in most metabolic processes that occur in cells.
Katarzyna Wozniak, Krzysztof Brzezinski
doaj   +1 more source

Peroxisomal Metabolite and Cofactor Transport in Humans

Frontiers in Cell and Developmental Biology, 2021
Peroxisomes are membrane-bound organelles involved in many metabolic pathways and essential for human health. They harbor a large number of enzymes involved in the different pathways, thus requiring transport of substrates, products and cofactors ...
Serhii Chornyi, Lodewijk IJlst, Carlo W. T. van Roermund, Ronald J. A. Wanders, Hans R. Waterham   +4 more
doaj   +1 more source

Beyond NPK: Mineral Nutrient-Mediated Modulation in Orchestrating Flowering Time

Plants, 2023
Flowering time in plants is a complex process regulated by environmental conditions such as photoperiod and temperature, as well as nutrient conditions.
Sang Eun Jun, Jae Sun Shim, Hee Jin Park
doaj   +1 more source

Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

eLife, 2020
Enzyme instability is an important limitation for the investigation and application of enzymes. Therefore, methods to rapidly and effectively improve enzyme stability are highly appealing. In this study we applied a computational method (FRESCO) to guide
Friso S Aalbers, Maximilian JLJ Fürst, Stefano Rovida, Milos Trajkovic, J Rubén Gómez Castellanos, Sebastian Bartsch, Andreas Vogel, Andrea Mattevi, Marco W Fraaije   +8 more
doaj   +1 more source

Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells

Frontiers in Immunology, 2021
Cofactors may explain why in some cases food ingestion leads to anaphylaxis while in others elicits a milder reaction or tolerance. With cofactors, reactions become more severe and/or have a lower allergen threshold. Cofactors are present in up to 58% of
Rosa Muñoz-Cano, Rosa Muñoz-Cano, Rosa Muñoz-Cano, Rosa Muñoz-Cano, Clara San Bartolome, Clara San Bartolome, Clara San Bartolome, Rocío Casas-Saucedo, Rocío Casas-Saucedo, Rocío Casas-Saucedo, Giovanna Araujo, Giovanna Araujo, Sonia Gelis, Sonia Gelis, Maria Ruano-Zaragoza, Maria Ruano-Zaragoza, Maria Ruano-Zaragoza, Jordi Roca-Ferrer, Jordi Roca-Ferrer, Jordi Roca-Ferrer, Francis Palomares, Francis Palomares, Margarita Martin, Margarita Martin, Margarita Martin, Joan Bartra, Joan Bartra, Joan Bartra, Joan Bartra, Mariona Pascal, Mariona Pascal, Mariona Pascal   +31 more
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Heterologous Expression of Ethanol Synthesis Pathway in Glycogen Deficient Synechococcus elongatus PCC 7942 Resulted in Enhanced Production of Ethanol and Exopolysaccharides

Frontiers in Plant Science, 2020
In this study, the Synechococcus elongatus PCC 7942 (hereafter S. elongatus) was engineered by the glgC knockout as well as the insertion of the pdc-adh genes from two different microorganisms.
Rajendran Velmurugan, Aran Incharoensakdi, Aran Incharoensakdi   +2 more
doaj   +1 more source

Cofactors of drug hypersensitivity—A monocenter retrospective analysis

Frontiers in Allergy, 2023
BackgroundDrug hypersensitivity reactions (DHRs) are major medical problems that influence the treatment of patients by both under- and overdiagnosis.
Johanna Kühl, Björn Bergh, Matthias Laudes, Silke Szymczak, Guido Heine   +4 more
doaj   +1 more source

Identification of YdhV as the first molybdoenzyme binding a Bis-Mo-MPT cofactor in escherichia coli [PDF]

, 2019
The oxidoreductase YdhV in Escherichia coli has been predicted to belong to the family of molybdenum/tungsten cofactor (Moco/Wco)-containing enzymes. In this study, we characterized the YdhV protein in detail, which shares amino acid sequence homology ...
Dau, Holger, Duffus, Benjamin R., Haumann, Michael, Leimkühler, Silke, Mebs, Stefan, Reschke, Stefan, Schrapers, Peer, Teutloff, Christian   +7 more
core   +1 more source

The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

eLife, 2021
Aggregation of Cu–Zn superoxide dismutase (SOD1) is implicated in the motor neuron disease, amyotrophic lateral sclerosis (ALS). Although more than 140 disease mutations of SOD1 are available, their stability or aggregation behaviors in membrane ...
Achinta Sannigrahi, Sourav Chowdhury, Bidisha Das, Amrita Banerjee, Animesh Halder, Amaresh Kumar, Mohammed Saleem, Athi N Naganathan, Sanat Karmakar, Krishnananda Chattopadhyay   +9 more
doaj   +1 more source