Results 1 to 10 of about 341,831 (272)

Peroxisomal Cofactor Transport [PDF]

Biomolecules, 2020
Peroxisomes are eukaryotic organelles that are essential for growth and development. They are highly metabolically active and house many biochemical reactions, including lipid metabolism and synthesis of signaling molecules.
Anastasija Plett, Lennart Charton, Nicole Linka   +2 more
doaj   +3 more sources

T cell subtype profiling measures exhaustion and predicts anti-PD-1 response

Scientific Reports, 2022
Anti-PD-1 therapy can provide long, durable benefit to a fraction of patients. The on-label PD-L1 test, however, does not accurately predict response.
Ian Schillebeeckx, Jon Earls, Kevin C. Flanagan, Jeffrey Hiken, Alex Bode, Jon R. Armstrong, David N. Messina, Douglas Adkins, Jessica Ley, Ilaria Alborelli, Philip Jermann, Jarret I. Glasscock   +11 more
doaj   +1 more source

Peroxisomal Metabolite and Cofactor Transport in Humans

Frontiers in Cell and Developmental Biology, 2021
Peroxisomes are membrane-bound organelles involved in many metabolic pathways and essential for human health. They harbor a large number of enzymes involved in the different pathways, thus requiring transport of substrates, products and cofactors ...
Serhii Chornyi, Lodewijk IJlst, Carlo W. T. van Roermund, Ronald J. A. Wanders, Hans R. Waterham   +4 more
doaj   +1 more source

Beyond NPK: Mineral Nutrient-Mediated Modulation in Orchestrating Flowering Time

Plants, 2023
Flowering time in plants is a complex process regulated by environmental conditions such as photoperiod and temperature, as well as nutrient conditions.
Sang Eun Jun, Jae Sun Shim, Hee Jin Park
doaj   +1 more source

Heterologous Expression of Ethanol Synthesis Pathway in Glycogen Deficient Synechococcus elongatus PCC 7942 Resulted in Enhanced Production of Ethanol and Exopolysaccharides

Frontiers in Plant Science, 2020
In this study, the Synechococcus elongatus PCC 7942 (hereafter S. elongatus) was engineered by the glgC knockout as well as the insertion of the pdc-adh genes from two different microorganisms.
Rajendran Velmurugan, Aran Incharoensakdi, Aran Incharoensakdi   +2 more
doaj   +1 more source

Biological Catalysis and Information Storage Have Relied on N-Glycosyl Derivatives of β-D-Ribofuranose since the Origins of Life

Biomolecules, 2023
Most naturally occurring nucleotides and nucleosides are N-glycosyl derivatives of β-d-ribose. These N-ribosides are involved in most metabolic processes that occur in cells.
Katarzyna Wozniak, Krzysztof Brzezinski
doaj   +1 more source

Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

eLife, 2020
Enzyme instability is an important limitation for the investigation and application of enzymes. Therefore, methods to rapidly and effectively improve enzyme stability are highly appealing. In this study we applied a computational method (FRESCO) to guide
Friso S Aalbers, Maximilian JLJ Fürst, Stefano Rovida, Milos Trajkovic, J Rubén Gómez Castellanos, Sebastian Bartsch, Andreas Vogel, Andrea Mattevi, Marco W Fraaije   +8 more
doaj   +1 more source

Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy

mBio, 2022
In bacteria, many essential metabolic processes are controlled by riboswitches, gene regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding enables riboswitches to respond to a single biologically relevant metabolite.
Kristopher J. Kennedy, Florian J. Widner, Olga M. Sokolovskaya, Lina V. Innocent, Rebecca R. Procknow, Kenny C. Mok, Michiko E. Taga   +6 more
doaj   +1 more source

Studies on the changes in protein fluorescence and enzymic activity of aspartate aminotransferase on binding of pyridoxal 5'-Phosphate [PDF]

, 1974
1. The a and ,B subforms of aspartate aminotransferase were purified from pig heart. 2. The a subform contained 2mol of pyridoxal 5'-phosphate. The apo-(a subform) could be fully reactived by combination with 2mol of cofactor. 3.
Evans, RW, Holbrook, J
core   +2 more sources

Identification and Expression Analysis of an Atypical Alkaline Phosphatase in Emiliania huxleyi

Frontiers in Microbiology, 2018
Emiliania huxleyi, a cosmopolitan coccolithophore in the modern ocean, plays an important role in the carbon cycle and local climate feedback as it can form extensive blooms, calcify, and produce dimethylsulfoniopropionate (DMSP) leading to the ...
Tangcheng Li, Chentao Guo, Yaqun Zhang, Cong Wang, Xin Lin, Senjie Lin, Senjie Lin   +6 more
doaj   +1 more source