Results 1 to 10 of about 419,459 (324)
Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 The oncoprotein transcription factor MYC is overexpressed in the majority of cancers. Key to its oncogenic activity is the ability of MYC to regulate gene expression patterns that drive and maintain the malignant state. MYC is also considered a validated
Adams, Clare M. +9 more
core +3 more sources
COFACTOR: an accurate comparative algorithm for structure-based protein function annotation [PDF]
Nucleic Acids Res., 2012 We have developed a new COFACTOR webserver for automated structure-based protein function annotation. Starting from a structural model, given by either experimental determination or computational modeling, COFACTOR first identifies template proteins of ...
Ambrish Roy, Jianyi Yang, Yang Zhang
openalex +2 more sources
The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria [PDF]
The ISME Journal, 2016 Blair Ney +12 more
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bioRxiv, 2021 The Rossmann fold enzymes are involved in essential biochemical pathways such as nucleotide and amino acid metabolism. Their functioning relies on interaction with cofactors, small nucleoside-based compounds specifically recognized by a conserved βαβ ...
K. Kamiński +6 more
semanticscholar +1 more source
Angewandte Chemie, 2020 Metal-organic frameworks (MOFs) have recently emerged as excellent hosting matrices for enzyme immobilization, offering superior physical and chemical protection for biocatalytic reactions.
Jieying Liang +9 more
semanticscholar +1 more source
The CoFactor database: organic cofactors in enzyme catalysis [PDF]
Bioinformatics, 2010 Abstract Motivation: Organic enzyme cofactors are involved in many enzyme reactions. Therefore, the analysis of cofactors is crucial to gain a better understanding of enzyme catalysis. To aid this, we have created the CoFactor database. Results: CoFactor provides a web interface to access hand-curated data extracted from ...
Fischer, Julia D. +2 more
openaire +2 more sources
Studies on the changes in protein fluorescence and enzymic activity of aspartate aminotransferase on binding of pyridoxal 5'-Phosphate [PDF]
, 1974 1. The a and ,B subforms of aspartate aminotransferase were purified from pig heart. 2. The a subform contained 2mol of pyridoxal 5'-phosphate. The apo-(a subform) could be fully reactived by combination with 2mol of cofactor. 3.
Evans, RW, Holbrook, J
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Geobiology, 2020 The nitrogenase metalloenzyme family, essential for supplying fixed nitrogen to the biosphere, is one of life's key biogeochemical innovations. The three forms of nitrogenase differ in their metal dependence, each binding either a FeMo‐, FeV‐, or FeFe ...
Amanda K. Garcia +3 more
semanticscholar +1 more source
The electronic complexity of the ground-state of the FeMo cofactor of nitrogenase as relevant to quantum simulations. [PDF]
Journal of Chemical Physics, 2018 We report that a recent active space model of the nitrogenase FeMo cofactor, proposed in the context of simulations on quantum computers, is not representative of the electronic structure of the FeMo cofactor ground-state.
Zhendong Li +4 more
semanticscholar +1 more source
Nucleic Acids Res., 2017 The COFACTOR web server is a unified platform for structure-based multiple-level protein function predictions. By structurally threading low-resolution structural models through the BioLiP library, the COFACTOR server infers three categories of protein ...
Chengxin Zhang +2 more
semanticscholar +1 more source