Results 1 to 10 of about 215,595 (302)

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

Advanced NanoBiomed Research
Therapeutic DNAzyme, often activated by catalytic cofactors in its central catalytic domain, has been extensively explored for the treatment of diverse diseases, primarily through mechanisms involving free release, notably within gene therapy frameworks.
Theoneste Muyizere, Julien Milon Essola, Eric Nyirimigabo, Janvier Mukiza, Jean Felix Mukerabigwi   +4 more
doaj   +1 more source

Waltzing around cofactors

eLife, 2016
The metallocofactor involved in fixing nitrogen is not a rigid scaffold, as was previously thought.
Wittenborn, Elizabeth Charlot, Chen, Yang-Ting, Drennan, Catherine L   +2 more
openaire   +5 more sources

Hydrogen‐Producing Catalysts Based on Ferredoxin Scaffolds

Advanced Science
Current attempts to transform our fossil fuel‐based society into a sustainable one involve learning from and employing the biochemistry of nature. The process of photosynthesis is exemplary for utilizing sunlight as a regenerative energy source.
Yiting She, Vera Engelbrecht, Jacek Kozuch, Ulf‐Peter Apfel, Sven T. Stripp, Anja Hemschemeier, Thomas Happe   +6 more
doaj   +1 more source

RUNX1 as a recombinase cofactor

Oncotarget, 2015
The regulation of TCR rearrangements, particularly of TCRδ and TCRβ, plays a decisive role in lymphoid differentiation and oncogenic transformation. Somatic assembly of TCR loci is established through V(D)J recombination during lymphocyte development.
Agata, Cieslak, Dominique, Payet-Bornet, Vahid, Asnafi   +2 more
openaire   +2 more sources

Retinoid X receptor γ interacts with peroxisome proliferator-activated receptor-γ to promote browning during adipose tissue differentiation

Adipocyte
Obesity and type 2 diabetes mellitus are global public health challenges. Activating thermogenic adipose tissues, such as brown adipose tissue and beige adipose tissue, could be a promising strategy to combat obesity and consequently obesity-related ...
Defei Chen, Saed Woraikat, Xiong Guo, Fuyu Yang, Chenglin Tang, Fan He, Kun Qian   +6 more
doaj   +1 more source

cofactors

, 2014
Citation: 'cofactors' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.C01128 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Novel target and cofactor repertoire for the transcriptional regulator JTY_0672 from Mycobacterium bovis BCG

Frontiers in Microbiology
Mycobacterium tuberculosis (Mtb) is the pathogenic agent of tuberculosis (TB). Intracellular survival plays a central role in the pathogenesis of Mtb in a manner that is dependent on an array of transcriptional regulators for Mtb.
Hui Wang, Xiaotian Li, Shuxian Wang, Ren Fang, Jiayin Xing, Ruiying Wu, Chunhui Zhang, Zhaoli Li, Ningning Song   +8 more
doaj   +1 more source

Potential of ascorbic acid in human health against different diseases: an updated narrative review

International Journal of Food Properties
Ascorbic acid (vitamin C) is the most crucial antioxidant for the body. The biochemical capabilities of ascorbic acid are still being studied. It acts as a cofactor for many enzymes participating in various physiological functions.
Anwar Ali, Sakhawat Riaz, Waseem Khalid, Maleeha Fatima, Umber Mubeen, Quratulain Babar, Muhammad Faisal Manzoor, Muhammad Zubair Khalid, Felix Kwashie Madilo   +8 more
doaj   +1 more source

Important Cofactors [PDF]

Deutsches Ärzteblatt international, 2011
openaire   +2 more sources

Identification and characterization of archaeal-type FAD synthase as a novel tractable drug target from the parasitic protozoa Entamoeba histolytica

mSphere
Flavin adenine dinucleotide (FAD) is an essential cofactor for numerous flavoenzymes present in all living organisms. The biosynthesis of FAD from riboflavin involves two sequential reactions catalyzed by riboflavin kinase and flavin adenine dinucleotide
Dewi Wulansari, Ghulam Jeelani, Euki Yazaki, Tomoyoshi Nozaki   +3 more
doaj   +1 more source