Results 1 to 10 of about 418,378 (371)

T cell subtype profiling measures exhaustion and predicts anti-PD-1 response

Scientific Reports, 2022
Anti-PD-1 therapy can provide long, durable benefit to a fraction of patients. The on-label PD-L1 test, however, does not accurately predict response.
Ian Schillebeeckx, Jon Earls, Kevin C. Flanagan, Jeffrey Hiken, Alex Bode, Jon R. Armstrong, David N. Messina, Douglas Adkins, Jessica Ley, Ilaria Alborelli, Philip Jermann, Jarret I. Glasscock   +11 more
doaj   +1 more source

Biological Catalysis and Information Storage Have Relied on N-Glycosyl Derivatives of β-D-Ribofuranose since the Origins of Life

Biomolecules, 2023
Most naturally occurring nucleotides and nucleosides are N-glycosyl derivatives of β-d-ribose. These N-ribosides are involved in most metabolic processes that occur in cells.
Katarzyna Wozniak, Krzysztof Brzezinski
doaj   +1 more source

Beyond NPK: Mineral Nutrient-Mediated Modulation in Orchestrating Flowering Time

Plants, 2023
Flowering time in plants is a complex process regulated by environmental conditions such as photoperiod and temperature, as well as nutrient conditions.
Sang Eun Jun, Jae Sun Shim, Hee Jin Park
doaj   +1 more source

Peroxisomal Metabolite and Cofactor Transport in Humans

Frontiers in Cell and Developmental Biology, 2021
Peroxisomes are membrane-bound organelles involved in many metabolic pathways and essential for human health. They harbor a large number of enzymes involved in the different pathways, thus requiring transport of substrates, products and cofactors ...
Serhii Chornyi, Lodewijk IJlst, Carlo W. T. van Roermund, Ronald J. A. Wanders, Hans R. Waterham   +4 more
doaj   +1 more source

Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy

mBio, 2022
In bacteria, many essential metabolic processes are controlled by riboswitches, gene regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding enables riboswitches to respond to a single biologically relevant metabolite.
Kristopher J. Kennedy, Florian J. Widner, Olga M. Sokolovskaya, Lina V. Innocent, Rebecca R. Procknow, Kenny C. Mok, Michiko E. Taga   +6 more
doaj   +1 more source

Heterologous Expression of Ethanol Synthesis Pathway in Glycogen Deficient Synechococcus elongatus PCC 7942 Resulted in Enhanced Production of Ethanol and Exopolysaccharides

Frontiers in Plant Science, 2020
In this study, the Synechococcus elongatus PCC 7942 (hereafter S. elongatus) was engineered by the glgC knockout as well as the insertion of the pdc-adh genes from two different microorganisms.
Rajendran Velmurugan, Aran Incharoensakdi, Aran Incharoensakdi   +2 more
doaj   +1 more source

Studies on the changes in protein fluorescence and enzymic activity of aspartate aminotransferase on binding of pyridoxal 5'-Phosphate [PDF]

, 1974
1. The a and ,B subforms of aspartate aminotransferase were purified from pig heart. 2. The a subform contained 2mol of pyridoxal 5'-phosphate. The apo-(a subform) could be fully reactived by combination with 2mol of cofactor. 3.
Evans, RW, Holbrook, J
core   +2 more sources

The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

eLife, 2021
Aggregation of Cu–Zn superoxide dismutase (SOD1) is implicated in the motor neuron disease, amyotrophic lateral sclerosis (ALS). Although more than 140 disease mutations of SOD1 are available, their stability or aggregation behaviors in membrane ...
Achinta Sannigrahi, Sourav Chowdhury, Bidisha Das, Amrita Banerjee, Animesh Halder, Amaresh Kumar, Mohammed Saleem, Athi N Naganathan, Sanat Karmakar, Krishnananda Chattopadhyay   +9 more
doaj   +1 more source

Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

eLife, 2020
Enzyme instability is an important limitation for the investigation and application of enzymes. Therefore, methods to rapidly and effectively improve enzyme stability are highly appealing. In this study we applied a computational method (FRESCO) to guide
Friso S Aalbers, Maximilian JLJ Fürst, Stefano Rovida, Milos Trajkovic, J Rubén Gómez Castellanos, Sebastian Bartsch, Andreas Vogel, Andrea Mattevi, Marco W Fraaije   +8 more
doaj   +1 more source

Cofactors of drug hypersensitivity—A monocenter retrospective analysis

Frontiers in Allergy, 2023
BackgroundDrug hypersensitivity reactions (DHRs) are major medical problems that influence the treatment of patients by both under- and overdiagnosis.
Johanna Kühl, Björn Bergh, Matthias Laudes, Silke Szymczak, Guido Heine   +4 more
doaj   +1 more source