Results 41 to 50 of about 409,776 (376)

A computational framework to emulate the human perspective in flow cytometric data analysis [PDF]

, 2012
Background: In recent years, intense research efforts have focused on developing methods for automated flow cytometric data analysis. However, while designing such applications, little or no attention has been paid to the human perspective that is ...
AP Dempster, B Ellis, B Lindsay, BG Lindsay, BW Silverman, BW Silverman, C Jarque, Christopher V. Rao, D Novo, D Sarkar, DJ Marchette, DR Parks, E Choy, E Lugli, F Hahne, F Hahne, F Hahne, G Finak, G Finak, G Luta, G McLachlan, H Zare, J Li, J Trotter, JA Hartigan, JA Hartigan, JM Irish, JP Baudry, K Lo, L Herzenberg, LM Maier, MC Minnotte, MY Cheng, MY Cheng, MY Cheng, N Aghaeepour, PM Hartigan, R Scheuermann, R Tibshirani, RR Brinkman, S Pyne, S Ray, S Ray, Saumyadipta Pyne, Surajit Ray, T Lin, T Lin   +46 more
core   +5 more sources

Waltzing around cofactors

eLife, 2016
The metallocofactor involved in fixing nitrogen is not a rigid scaffold, as was previously thought.
Wittenborn, Elizabeth Charlot, Chen, Yang-Ting, Drennan, Catherine L   +2 more
openaire   +6 more sources

Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly

Open Veterinary Journal, 2023
Background: In 2015, an unprecedented epidemic of microcephaly occurred in Brazil. Preliminary observations suggested involvement of cofactors in the etiopathology of Zika virus associated microcephaly.
Massimo Giangaspero, Tamaki Okabayashi
doaj   +1 more source

Identification of YdhV as the first molybdoenzyme binding a Bis-Mo-MPT cofactor in escherichia coli [PDF]

, 2019
The oxidoreductase YdhV in Escherichia coli has been predicted to belong to the family of molybdenum/tungsten cofactor (Moco/Wco)-containing enzymes. In this study, we characterized the YdhV protein in detail, which shares amino acid sequence homology ...
Dau, Holger, Duffus, Benjamin R., Haumann, Michael, Leimkühler, Silke, Mebs, Stefan, Reschke, Stefan, Schrapers, Peer, Teutloff, Christian   +7 more
core   +1 more source

Five-coordinate MnIV intermediate in the activation of nature’s water splitting cofactor

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Recent results have shown that nature’s water splitting catalyst inserts an additional water molecule into what appears to be a solvent inaccessible site late in its reaction cycle.
Maria Chrysina, Eiri Heyno, Y. Kutin, M. Reus, H. Nilsson, M. Nowaczyk, S. DeBeer, F. Neese, J. Messinger, W. Lubitz, N. Cox   +10 more
semanticscholar   +1 more source

Cofactor and Cofactor Mimetics

Blood, 2019
Many natural enzymes need the assistance of protein cofactors to catalyze chemical reactions at a physiologically relevant speed and several of the enzymes that make up for the coagulation cascade are no exception in this regard. Notably, activated factors VII, IX and X display relatively poor enzymatic activity towards their respective macromolecular ...
openaire   +2 more sources

Characterization of an M-Cluster-Substituted Nitrogenase VFe Protein

mBio, 2018
The Mo- and V-nitrogenases are two homologous members of the nitrogenase family that are distinguished mainly by the presence of different heterometals (Mo or V) at their respective cofactor sites (M- or V-cluster).
Johannes G. Rebelein, Chi Chung Lee, Megan Newcomb, Yilin Hu, Markus W. Ribbe   +4 more
doaj   +1 more source

Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin

Pharmaceuticals, 2021
Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2′-O-methylation of ribosomal RNAs (rRNAs), a ...
Yun Shi, Ibrahim M. El-Deeb, Veronika Masic, Lauren Hartley-Tassell, Andrea Maggioni, Mark von Itzstein, Thomas Ve   +6 more
doaj   +1 more source

Molybdenum cofactor deficiency

Atlas of Inherited Metabolic Diseases, 2018
Molybdenum cofactor deficiency is a rare condition characterized by brain dysfunction (encephalopathy) that worsens over time. Babies with this condition appear normal at birth, but within a week they have difficulty feeding and develop seizures that do ...
C. Staufner
semanticscholar   +1 more source

Cofactor matrices

Linear Algebra and its Applications, 1992
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source