Results 41 to 50 of about 349,815 (226)
BMC CancerBackground While immune checkpoint inhibitor (ICI) therapies can significantly improve outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC), only about 15–20% benefit from such treatments.
Jeffrey Hiken +7 more
doaj +1 more source
The CoFactor database: organic cofactors in enzyme catalysis [PDF]
Bioinformatics, 2010 Abstract Motivation: Organic enzyme cofactors are involved in many enzyme reactions. Therefore, the analysis of cofactors is crucial to gain a better understanding of enzyme catalysis. To aid this, we have created the CoFactor database. Results: CoFactor provides a web interface to access hand-curated data extracted from ...
Fischer, Julia D. +2 more
openaire +2 more sources
Non-Hamiltonian systems separable by Hamilton-Jacobi method
, 2007 We show that with every separable calssical Stackel system of Benenti type on a Riemannian space one can associate, by a proper deformation of the metric tensor, a multi-parameter family of non-Hamiltonian systems on the same space, sharing the same ...
Beltrami +20 more
core +1 more source
Characterization of an M-Cluster-Substituted Nitrogenase VFe Protein
mBio, 2018 The Mo- and V-nitrogenases are two homologous members of the nitrogenase family that are distinguished mainly by the presence of different heterometals (Mo or V) at their respective cofactor sites (M- or V-cluster).
Johannes G. Rebelein +4 more
doaj +1 more source
Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin)
Molecules, 2020 Visceral adipose tissue derived serine protease inhibitor (vaspin) is a member of the serpin family and has been shown to have beneficial effects on glucose tolerance, insulin stability as well as adipose tissue inflammation, parameters seriously ...
Catherine A. Tindall +6 more
doaj +1 more source
OPTIMIZATION OF ENZYME PARAMETERS FOR FERMENTATIVE PRODUCTION OF BIORENEWABLE FUELS AND CHEMICALS
Computational and Structural Biotechnology Journal, 2012 Microbial biocatalysts such as Escherichia coli and Saccharomyces cerevisiae have been extensively subjected to Metabolic Engineering for the fermentative production of biorenewable fuels and chemicals. This often entails the introduction of new enzymes,
Laura R. Jarboe +3 more
doaj +1 more source
Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance. [PDF]
, 2019 The oncoprotein transcription factor MYC is overexpressed in the majority of cancers. Key to its oncogenic activity is the ability of MYC to regulate gene expression patterns that drive and maintain the malignant state. MYC is also considered a validated
Adams, Clare M. +9 more
core +1 more source
A Recursive Scheme of First Integrals of the Geodesic Flow of a Finsler Manifold [PDF]
, 2007 We review properties of so-called special conformal Killing tensors on a Riemannian manifold $(Q,g)$ and the way they give rise to a Poisson-Nijenhuis structure on the tangent bundle $TQ$.
Sarlet, Willy
core +4 more sources
Molecules1,4-diaminobutane is widely used in the industrial production of polymers, pharmaceuticals, agrochemicals and surfactants. Owing to economic and environmental concerns, there has been a growing interest in using microbes to produce 1,4-diaminobutane ...
Tong Sun +9 more
doaj +1 more source
Cofactor and Process Engineering for Nicotinamide Recycling and Retention in Intensified Biocatalysis [PDF]
, 2022 Raquel Abdallah da Rocha +4 more
openalex +1 more source