Results 51 to 60 of about 418,378 (371)

Protein S as Cofactor for TFPI [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2009
In the last decades evidence was obtained that protein S not only acts as cofactor of activated protein C (APC) in the downregulation of coagulation, but also expresses anticoagulant activity in the absence of APC. The search for the mechanism(s) underlying the APC-independent anticoagulant activity of protein S was hampered by the fact that protein S ...
Tilman M. Hackeng, Jan Rosing
openaire   +3 more sources

Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes

Frontiers in Pharmacology, 2023
Many enzymes require post-translational modifications or cofactor machinery for primary function. As these catalytically essential moieties are highly regulated, they act as dual sensors and chemical handles for context-dependent metabolic activity ...
Katelyn A. Bustin, Arwa Abbas, Xie Wang, Michael C. Abt, Joseph P. Zackular, Joseph P. Zackular, Megan L. Matthews   +6 more
doaj   +1 more source

Electron Transfer Precedes ATP Hydrolysis during Nitrogenase Catalysis [PDF]

, 2013
The biological reduction of N2 to NH3 catalyzed by Mo-dependent nitrogenase requires at least eight rounds of a complex cycle of events associated with ATP-driven electron transfer (ET) from the Fe protein to the catalytic MoFe protein, with each ET ...
Antony, Edwin, Danyal, Karamatullah, Dean, Dennis R., Duval, Simon, Hoffman, Brian M., Lytle, Anna K., Seefeldt, Lance C., Shaw, Sudipta   +7 more
core   +2 more sources

Cofactor-mediated amyloidogenesis [PDF]

Bioscience Reports, 2019
Abstract A recent study published in Bioscience Reports by Sheng et al. (Bioscience Reports, (2019) 39, pii:BSR20182345] described a small but significant conformational change that occurs upon zinc binding and results in initiation of the amyloidogenic aggregation cascade of Golgi-Associated plant Pathogenesis Related protein 1 (GAPR-1)
openaire   +3 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Analytical performance of OncoPrism-HNSCC, an RNA-based assay to inform immune checkpoint inhibitor treatment decisions for recurrent/metastatic head and neck squamous cell carcinoma

BMC Cancer
Background While immune checkpoint inhibitor (ICI) therapies can significantly improve outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC), only about 15–20% benefit from such treatments.
Jeffrey Hiken, Jon Earls, Kevin C. Flanagan, Rachel L. Wellinghoff, Michelle Ponder, David N. Messina, Jarret I. Glasscock, Eric J. Duncavage   +7 more
doaj   +1 more source

Characterization of an M-Cluster-Substituted Nitrogenase VFe Protein

mBio, 2018
The Mo- and V-nitrogenases are two homologous members of the nitrogenase family that are distinguished mainly by the presence of different heterometals (Mo or V) at their respective cofactor sites (M- or V-cluster).
Johannes G. Rebelein, Chi Chung Lee, Megan Newcomb, Yilin Hu, Markus W. Ribbe   +4 more
doaj   +1 more source

CASCADE: high-throughput characterization of regulatory complex binding altered by non-coding variants

Cell Genomics, 2022
Summary: Non-coding DNA variants (NCVs) impact gene expression by altering binding sites for regulatory complexes. New high-throughput methods are needed to characterize the impact of NCVs on regulatory complexes.
David Bray, Heather Hook, Rose Zhao, Jessica L. Keenan, Ashley Penvose, Yemi Osayame, Nima Mohaghegh, Xiaoting Chen, Sreeja Parameswaran, Leah C. Kottyan, Matthew T. Weirauch, Trevor Siggers   +11 more
doaj   +1 more source

On the Metal Cofactor in the Tyrosinase Family

International Journal of Molecular Sciences, 2018
The production of pigment in mammalian melanocytes requires the contribution of at least three melanogenic enzymes, tyrosinase and two other accessory enzymes called the tyrosinase-related proteins (Trp1 and Trp2), which regulate the type and amount of ...
F. Solano
semanticscholar   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source