Results 51 to 60 of about 4,023,080 (310)

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Exploring Ho Chi Minh City's Coffee Value Chain through the Unique Intersection of Specialty Coffee and Tourism

Khazanah Sosial
The study dives into the thriving coffee culture of Ho Chi Minh City, Vietnam, and investigates its significant impact on tourism and economic growth.
Kurniawan Arif Maspul
doaj   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

Trichoderma Asal Akar Kopi Dari Alor: Karakterisasi Morfologi dan Keefektifannya Menghambat Colletotrichum Penyebab Penyakit Antraknosa secara in Vitro

Jurnal Fitopatologi Indonesia, 2020
Trichoderma of Coffee Roots From Alor: Morphological characteristic and in vitro Efficacy to Inhibit Colletotrichum Causing Anthracnose Trichoderma is a fungus capable of intimate associations with plant root systems including on coffee plants.
Didiana Yanuarita Molebila, Ade Rosmana, Untung Surapaty Tresnaputra   +2 more
doaj   +1 more source

Hot Coffee: The Identity, Climate Profiles, Agronomy, and Beverage Characteristics of Coffea racemosa and C. zanguebariae

Frontiers in Sustainable Food Systems, 2021
Climate change poses a considerable challenge for coffee farming, due to increasing temperatures, worsening weather perturbations, and shifts in the quantity and timing of precipitation. Of the actions required for ensuring climate resilience for coffee,
Aaron P. Davis, Roberta Gargiulo, Iolanda N. das M. Almeida, Marcelino Inácio Caravela, Charles Denison, Justin Moat   +5 more
doaj   +1 more source

Proof of Concept for Cell Culture-Based Coffee

Journal of Agricultural and Food Chemistry, 2023
The global coffee production is facing serious challenges including land use, climate change, and sustainability while demand is rising. Cellular agriculture is a promising alternative to produce plant-based commodities such as coffee, which are conventionally produced by farming.
Kärkkäinen, Elviira, Jokinen, Iina, Seppänen-Laakso, Tuulikki, Rischer, Heiko, Aisala, Heikki   +5 more
openaire   +3 more sources

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Coffee Shop Culture: An Observation Study to Coffee Shop Patron

Proceeding ISETH (International Summit on Science, Technology, and Humanity), 2023
Purpose : This research aims to investigate the manner in which customers engage in activities, communicate with each other and with coffee shop attendants, and adhere to the established etiquette in coffee shop environments. Methodology : To achieve these objectives, this study employs Herbert Blumer's Symbolic Interactionism Theory and Ray Oldenburg ...
Fitria Anggraeni, P Palupi
openaire   +1 more source

Allium sativum, a Natural and Pharmaco‐Remedial Panacea for Entero‐Gastritis, Antibiocidal/Dysbiogenesis, and Systemic Health Relevance

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Natural Pharmaco‐remedial impacts of Allium sativum on Systemic health. ABSTRACT Arising from the emergence of diverse difficult‐to‐treat health cases, alterative‐therapeutic strategies have become a potential way forward for management/control. In traditional Chinese medicine (TCM), various plant materials have been sourced as alterative‐therapeutic ...
Patience O. Adomi, Bright E. Igere, Anthony J. Anozie, Oghenenyore A. Ohwokevwo   +3 more
wiley   +1 more source

Do More Open Economies Export Less Diversely in Brazilian Agribusiness?

Agribusiness, EarlyView.
ABSTRACT This paper asks whether municipalities with a larger export‐to‐revenue ratio display a more concentrated bundle of exported goods in Brazilian agribusiness. Recent advances in export imputation for Brazilian municipalities allow for an analysis of the concentration profile of each municipality and its association with export openness.
Alan Leal, Michelle Marcia Viana Martins
wiley   +1 more source