Results 81 to 90 of about 1,548,183 (362)

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

open access: yesFEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten   +10 more
wiley   +1 more source

A Comparison of Different Cognitive Paradigms Using Simple Animats in a Virtual Laboratory, with Implications to the Notion of Cognition [PDF]

open access: yes, 2002
In this thesis I present a virtual laboratory which implements five different models for controlling animats: a rule-based system, a behaviour-based system, a concept-based system, a neural network, and a Braitenberg architecture.
Gershenson, Carlos
core  

The Cognitive Basis of Computation: Putting Computation in Its Place [PDF]

open access: yes, 2018
The mainstream view in cognitive science is that computation lies at the basis of and explains cognition. Our analysis reveals that there is no compelling evidence or argument for thinking that brains compute.
Hutto, Daniel D.   +3 more
core   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

Implicit cognition is impaired and dissociable in a head-injured group with executive deficits [PDF]

open access: yes, 2005
Implicit or non-conscious cognition is traditionally assumed to be robust to pathology but Gomez-Beldarrain et al (1999, 2002) recently showed deficits on a single implicit task after head injury.
Andrade, J.   +4 more
core   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Toward a Formal Model of Cognitive Synergy [PDF]

open access: yesarXiv, 2017
"Cognitive synergy" refers to a dynamic in which multiple cognitive processes, cooperating to control the same cognitive system, assist each other in overcoming bottlenecks encountered during their internal processing. Cognitive synergy has been posited as a key feature of real-world general intelligence, and has been used explicitly in the design of ...
arxiv  

Computational Inference in Cognitive Science: Operational, Societal and Ethical Considerations [PDF]

open access: yesarXiv, 2022
Emerging research frontiers and computational advances have gradually transformed cognitive science into a multidisciplinary and data-driven field. As a result, there is a proliferation of cognitive theories investigated and interpreted from different academic lens and in different levels of abstraction.
arxiv  

Benefits of the Global Integration Method (Método de Integração Global - MIG) in functional priorities of parents of Brazilian children and adolescents with autism spectrum disorder

open access: yesBMC Pediatrics
Background Understanding the priorities of parents of children and adolescents with autism spectrum disorder (ASD) is crucial for implementing evidence-based programs. This study aims to identify the functional priorities of parents of Brazilian children
Amanda Aparecida Alves Cunha Nascimento   +5 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

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