Results 81 to 90 of about 2,177,617 (385)

Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling

Nature Communications, 2019
Kleefstra syndrome is a neurodevelopmental disorder associated with hapoinsufficiency of the histone methyltransferase EHMT1. Here the authors show using induced pluripotent cells-derived neurons from patients that network dysfunction occurs and is due ...
Monica Frega, Katrin Linda, Jason M. Keller, Güvem Gümüş-Akay, Britt Mossink, Jon-Ruben van Rhijn, Moritz Negwer, Teun Klein Gunnewiek, Katharina Foreman, Nine Kompier, Chantal Schoenmaker, Willem van den Akker, Ilse van der Werf, Astrid Oudakker, Huiqing Zhou, Tjitske Kleefstra, Dirk Schubert, Hans van Bokhoven, Nael Nadif Kasri   +18 more
doaj   +1 more source

Computation vs. Information Processing: Why Their Difference Matters to Cognitive Science [PDF]

, 2009
Since the cognitive revolution, it’s become commonplace that cognition involves both computation and information processing. Is this one claim or two? Is computation the same as information processing?
Piccinini, Dr. Gualtiero, Scarantino, Dr. Andrea   +1 more
core  

The effects of context processing on social cognition impairments in adults with Aspergers syndrome [PDF]

, 2014
Social cognition—the basis of all communicative and otherwise interpersonal relationships—is embedded in specific contextual circumstances which shape intrinsic meanings.
Báez Buitrago, Sandra Jimena, Ibañez, Agustin Mariano   +1 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Benefits of the Global Integration Method (Método de Integração Global - MIG) in functional priorities of parents of Brazilian children and adolescents with autism spectrum disorder

BMC Pediatrics
Background Understanding the priorities of parents of children and adolescents with autism spectrum disorder (ASD) is crucial for implementing evidence-based programs. This study aims to identify the functional priorities of parents of Brazilian children
Amanda Aparecida Alves Cunha Nascimento, Deisiane Oliveira Souto, Thalita Karla Flores Cruz, Arthur Felipe Barroso de Lima, Gabriela Silva Oliveira, Vitor Geraldi Haase   +5 more
doaj   +1 more source

Immune cognition, social justice and asthma: structured stress and the developing immune system [PDF]

, 2001
We explore the implications of IR Cohen's work on immune cognition for understanding rising rates of asthma morbidity and mortality in the US. Immune cognition is conjoined with central nervous system cognition, and with the cognitive function of the ...
Fullilove, Mindy, Wallace, Deborah, Wallace, Rodrick   +2 more
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Semantic associative abilities and executive control functions predict novelty and appropriateness of idea generation

Communications Biology
Novelty and appropriateness are two fundamental components of creativity. However, the way in which novelty and appropriateness are separated at behavioral and neural levels remains poorly understood.
Xueyang Wang, Qunlin Chen, Kaixiang Zhuang, Jingyi Zhang, Robert A. Cortes, Daniel D. Holzman, Li Fan, Cheng Liu, Jiangzhou Sun, Xianrui Li, Yu Li, Qiuyang Feng, Hong Chen, Tingyong Feng, Xu Lei, Qinghua He, Adam E. Green, Jiang Qiu   +17 more
doaj   +1 more source

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

JAMA Neurology, 2019
Key Points Question Is cognitive decline associated with amyloid-β or tau tangles accumulation? Findings In this cohort study that included 60 normal older adults with repeated positron emission tomography measures, the rate of tau accumulation in the ...
Bernard J. Hanseeuw, Bernard J. Hanseeuw, R. Betensky, H. I. Jacobs, H. I. Jacobs, A. Schultz, J. Sepulcre, J. Becker, Danielle M. Cosio, Michelle E. Farrell, Y. Quiroz, Elizabeth C. Mormino, Elizabeth C. Mormino, Rachel F Buckley, Rachel F Buckley, Rachel F Buckley, K. Papp, K. Papp, Rebecca Amariglio, Rebecca Amariglio, Ilse Dewachter, Ilse Dewachter, A. Ivanoiu, A. Ivanoiu, W. Huijbers, W. Huijbers, T. Hedden, G. Marshall, G. Marshall, J. Chhatwal, D. Rentz, D. Rentz, R. Sperling, R. Sperling, Keith A. Johnson, Keith A. Johnson   +35 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source