Results 81 to 90 of about 538,409 (298)

Cognitive Reserve? Cognitive Capacity!

Brain Sciences
The concept of cognitive reserve (CR) has been a cornerstone in cognitive aging research, offering a framework to explain how life experiences like education, occupation, bilingualism, and physical exercise may buffer individuals from cognitive decline in the face of aging or neurological disease.
openaire   +3 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Harmonizing cross-cultural and transdiagnostic assessment of social cognition by expert panel consensus

Schizophrenia
Social cognition, the perception and processing of social information, is adversely affected in multiple psychiatric, neurological, and neurodevelopmental disorders, and these impairments negatively impact quality of life for individuals across the globe.
Amy E. Pinkham, Michal Hajdúk, Tim Ziermans, the SIRS Social Cognition Research Harmonization Group   +3 more
doaj   +1 more source

Mnemonic convergence in the human hippocampus

Nature Communications, 2016
The ability to form associations between events is the hallmark of episodic memory and is thought to involve the hippocampus. Here the authors use a combination of multivariate pattern and graph theoretical network analyses of functional imaging data in ...
Alexander R. Backus, Sander E. Bosch, Matthias Ekman, Alejandro Vicente Grabovetsky, Christian F. Doeller   +4 more
doaj   +1 more source

THE IMPACT OF NEGATIVE AFFECT ON COGNITION AND PERSONALITY1 [PDF]

, 1965
Samuel Messick
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Construction and Cognition

THEORIA, 2009
The Structure of Appearance presents a phenomenalist system which constructs enduring visible objects out of qualia. Nevertheless Goodman does not espouse phenomenalism. Why not? In answering this question this paper explicates Goodman's views about the nature and functions of constructional systems, the prospects of reductionism, and the character of
openaire   +4 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

“R” you getting this? Factors contributing to the public’s understanding, evaluation, and use of basic reproduction numbers for infectious diseases

BMC Public Health
Background We (1) examined the effects of evaluative labels and visual aids on people’s understanding, evaluation, and use of the COVID-19 reproduction number (or “r-number”), (2) examined whether people’s perceived susceptibility and (intended ...
Ruben D. Vromans, Nadine Bol, Marloes M. C. van Wezel, Emiel J. Krahmer   +3 more
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

CURRICULUM, COGNITION, AND EDUCATIONAL MEASUREMENT1 [PDF]

, 1963
Robert W. Heath
openalex   +1 more source