Results 81 to 90 of about 2,085,476 (385)

Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling

Nature Communications, 2019
Kleefstra syndrome is a neurodevelopmental disorder associated with hapoinsufficiency of the histone methyltransferase EHMT1. Here the authors show using induced pluripotent cells-derived neurons from patients that network dysfunction occurs and is due ...
Monica Frega, Katrin Linda, Jason M. Keller, Güvem Gümüş-Akay, Britt Mossink, Jon-Ruben van Rhijn, Moritz Negwer, Teun Klein Gunnewiek, Katharina Foreman, Nine Kompier, Chantal Schoenmaker, Willem van den Akker, Ilse van der Werf, Astrid Oudakker, Huiqing Zhou, Tjitske Kleefstra, Dirk Schubert, Hans van Bokhoven, Nael Nadif Kasri   +18 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Benefits of the Global Integration Method (Método de Integração Global - MIG) in functional priorities of parents of Brazilian children and adolescents with autism spectrum disorder

BMC Pediatrics
Background Understanding the priorities of parents of children and adolescents with autism spectrum disorder (ASD) is crucial for implementing evidence-based programs. This study aims to identify the functional priorities of parents of Brazilian children
Amanda Aparecida Alves Cunha Nascimento, Deisiane Oliveira Souto, Thalita Karla Flores Cruz, Arthur Felipe Barroso de Lima, Gabriela Silva Oliveira, Vitor Geraldi Haase   +5 more
doaj   +1 more source

Task modulation of brain responses in visual word recognition as studied using EEG/MEG and fMRI

Frontiers in Human Neuroscience, 2013
Do task demands change the way we extract information from a stimulus, or only how we use this information for decision making? In order to answer this question for visual word recognition, we used EEG/MEG as well as fMRI to determine the latency ranges ...
Yuanyuan eChen, Yuanyuan eChen, Matthew H Davis, Friedemann ePulvermüller, Friedemann ePulvermüller, Olaf eHauk   +5 more
doaj   +1 more source

Immune cognition, social justice and asthma: structured stress and the developing immune system [PDF]

, 2001
We explore the implications of IR Cohen's work on immune cognition for understanding rising rates of asthma morbidity and mortality in the US. Immune cognition is conjoined with central nervous system cognition, and with the cognitive function of the ...
Fullilove, Mindy, Wallace, Deborah, Wallace, Rodrick   +2 more
core  

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

The effects of context processing on social cognition impairments in adults with Aspergers syndrome [PDF]

, 2014
Social cognition—the basis of all communicative and otherwise interpersonal relationships—is embedded in specific contextual circumstances which shape intrinsic meanings.
Báez Buitrago, Sandra Jimena, Ibañez, Agustin Mariano   +1 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Tree shrews (tupaia belangeri) exhibit novelty preference in the novel location memory task with 24-hour retention periods.

Frontiers in Psychology, 2014
Novelty preference is pervasive in mammalian species, and describes an inherent tendency to preferentially explore novelty. The novel location memory task studied here assesses the ability of animals to form accurate memories of a spatial configuration,
Jayakrishnan H R Nair, Jayakrishnan H R Nair, Marlene eTopka, Marlene eTopka, Abbas eKhani, Abbas eKhani, Manuela eIsenschmid, Gregor eRainer, Gregor eRainer   +8 more
doaj   +1 more source

Materiality and human cognition [PDF]

, 2019
In this paper, we examine the role of materiality in human cognition. We address issues such as the ways in which brain functions may change in response to interactions with material forms, the attributes of material forms that may cause change in brain ...
Overmann, Karenleigh, Wynn, Thomas
core