Results 81 to 90 of about 3,804,279 (378)

The association between gray matter volume in the hippocampal subfield and antidepressant efficacy mediated by abnormal dynamic functional connectivity

Scientific Reports
An abnormality of structures and functions in the hippocampus may have a key role in the pathophysiology of major depressive disorder (MDD). However, it is unclear whether structure factors of the hippocampus effectively impact antidepressant responses ...
Changxiao Kuai, Jiayong Pu, Donglin Wang, Zhonglin Tan, Yan Wang, Shao-Wei Xue   +5 more
doaj   +1 more source

Gait and cognition: mapping the global and discrete relationships in ageing and neurodegenerative disease [PDF]

, 2016
Recent research highlights the association of gait and cognition in older adults but a stronger understanding is needed to discern coincident pathophysiology, patterns of change, examine underlying mechanisms and aid diagnosis.
Bunce, Jennifer, Burn, David, Lord, Sue, Morris, Rosie, Rochester, Lynn   +4 more
core   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The effects of impulsivity and proactive inhibition on reactive inhibition and the go process: insights from the stop signal task of vocal and manual responses

Frontiers in Human Neuroscience, 2015
This study measured proactive and reactive response inhibition and their relationships with self-reported impulsivity. We examined the domains of both vocal and manual responding using a stop signal task (SST) with two stop probabilities: high and low ...
Leidy Janeth Castro-Meneses, Leidy Janeth Castro-Meneses, Blake Warren Johnson, Paul Fredrick Sowman, Paul Fredrick Sowman   +4 more
doaj   +1 more source

Design of the PERSPECTIVE study: PERsonalized SPEeCh Therapy for actIVE conversation in Parkinson’s disease (randomized controlled trial)

Trials, 2022
Objective To evaluate the effectiveness of personalized and home-based speech therapy on quality of life, intelligibility, and social participation for people with Parkinson’s disease (PD) who have a reduced intelligibility of speech.
J. J. L. Maas, N. M. De Vries, B. R. Bloem, J. G. Kalf   +3 more
doaj   +1 more source

Genetic contributions to visuospatial cognition in Williams syndrome: insights from two contrasting partial deletion patients [PDF]

, 2014
Background Williams syndrome (WS) is a rare neurodevelopmental disorder arising from a hemizygotic deletion of approximately 27 genes on chromosome 7, at locus 7q11.23.
A Antonell, A Karmiloff-Smith, A Karmiloff-Smith, A Karmiloff-Smith, AD Smith, AE Richardson, Annette Karmiloff-Smith, B Landau, BR Pober, C Fusco, C Schubert, CA Morris, CC Hoogenraad, CD Elliott, D Voyer, D Wechsler, E Mellet, EJ Young, EK Farran, EK Farran, EK Farran, EK Farran, EK Farran, Emily K Farran, Emma Meaburn, Esther Chin, Francis Sansbury, G Vandeweyer, H Hirota, Hannah Broadbent, HJ Broadbent, HJ Broadbent, HR Purser, J Bullens, J Bullens, J Fenner, J Huttenlocher, J Raven, J Van Herwegen, JM Frangiskakis, JM Zacks, JR Crawford, JR Crawford, JR Pani, K Iglói, K Iglói, Kay Metcalfe, L Dai, LR Osborne, M Bayes, M Castelo-Branco, M Fayasse, M Hegarty, M Hegarty, M Kozhevnikov, M Nardini, M Nardini, M Tassabehji, M Tassabehji, MA Porter, May Tassabehji, N Newcombe, Peter Turnpenny, RN Shepard, U Bellugi, U Koehler, V Gray, Y Meng, Z Urban   +68 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

ΔFosB Regulates Gene Expression and Cognitive Dysfunction in a Mouse Model of Alzheimer\u27s Disease. [PDF]

, 2017
Alzheimer\u27s disease (AD) is characterized by cognitive decline and 5- to 10-fold increased seizure incidence. How seizures contribute to cognitive decline in AD or other disorders is unclear.
Aschmies, Suzan, Ashok, Annie, Chin, Jeannie, Corbett, Brian F, Fu, Chia-Hsuan, Hazra, Anupam, Iascone, Daniel M, Nestler, Eric J, Petrof, Iraklis, Pyfer, Mark S, Stephens, Gabriel S, Tosi, Umberto, You, Jason C, Zhang, Xiaohong, Zhao, Lijuan   +14 more
core   +1 more source

Emotional health in adolescents with and without a history of specific language impairment (SLI) [PDF]

, 2008
Objective:  This study examined the emotional health of adolescents with and without specific language impairment (SLI). Method:  One hundred and thirty-nine adolescents with a history of SLI (15;10 years) and a peer group of 124 adolescents with ...
American Psychiatric Association., Bishop D.V.M., Botting N., Brownlie E.B., Cantwell D.P., Conti-Ramsden G., Conti-Ramsden G., Conti-Ramsden G., Conti-Ramsden G., Durkin K., Ellis-Weismer S., Knox E., Office for National Statistics., Raven J.C., Renfrew C., Semel E., Stothard S.E., Tomblin J.B., Wechsler D., Wechsler D.   +19 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source