Results 81 to 90 of about 280,147 (323)

Disorders of Visuo-spatial Cognition

Neurocase, 2005
Disorders of visuo-spatial ...
Humphreys, G, Husain, M, Farné, A, Rorden, C, Bartolomeo, Paolo   +4 more
openaire   +4 more sources

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Cognitive computation of brain disorders based primarily on ocular responses [PDF]

arXiv, 2019
The present review presents multiple techniques in which ocular assessments may serve as a noninvasive approach for the early diagnoses of various cognitive and psychiatric disorders, such as Alzheimer's disease (AD), autism spectrum disorder (ASD), schizophrenia (SZ), and major depressive disorder (MDD).
arxiv  

Cognitive style in bipolar disorder [PDF]

British Journal of Psychiatry, 2005
BackgroundAbnormalities of cognitive style in bipolar disorder are of both clinical and theoretical importance.AimsTo compare cognitive style in people with affective disorders and in healthy controls.MethodSelf-rated questionnaires were administered to 118 individuals with bipolar I disorder, 265 with unipolar major recurrent depression and 268 ...
Jones, L, Scott, J, Haque, S, Gordon-Smith, K, Heron, J, Caesar, S, Cooper, C, Forty, L, Hyde, S, Lyon, L, Greening, J, Sham, P, Farmer, A, McGuffin, P, Jones, I, Craddock, N   +15 more
openaire   +5 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Increased individual variability in functional connectivity of the default mode network and its genetic correlates in major depressive disorder

Scientific Reports
Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder characterized with considerable individual variability in clinical manifestations which may correspond to brain alterations including the default mode network (DMN).
Chi Yao, Peng Wang, Yang Xiao, Yuhong Zheng, Jiayong Pu, Yongwei Miao, Jinghua Wang, Shao-Wei Xue   +7 more
doaj   +1 more source

Importance of the inverted control in measuring holistic face processing with the composite effect and part-whole effect.

Frontiers in Psychology, 2013
Holistic coding for faces is shown in several illusions that demonstrate integration of the percept across the entire face. The illusions occur upright but, crucially, not inverted.
Elinor eMcKone, Elinor eMcKone, Anne eAimola Davies, Anne eAimola Davies, Hayley eDarke, Kate eCrookes, Kate eCrookes, Tushara eWickramariyaratne, Stephanie eZappia, Chiara eFiorentini, Chiara eFiorentini, Simone eFavelle, Mary eBroughton, Dinusha eFernando   +13 more
doaj   +1 more source

Hypoxia Augments Cerebral Inflammation in a Dextran Sulfate Sodium-Induced Colitis Mouse Model

Frontiers in Cellular Neuroscience, 2020
The importance of hypoxia in the pathophysiology of inflammatory bowel disease (IBD) is increasingly being realized; also, hypoxia seems to be an important accelerator of brain inflammation, as has been reported by our group and others.
Ying Han, Ying Han, Liping Ding, Xiang Cheng, Ming Zhao, Tong Zhao, Liang Guo, Xinyang Li, Yanan Geng, Yanan Geng, Ming Fan, Ming Fan, Hong Liao, Lingling Zhu, Lingling Zhu   +14 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Caregiver burden in Parkinson’s disease: a mixed-methods study

BMC Medicine, 2023
Background Providing informal care for a person with Parkinson’s disease (PD) can be a demanding process affecting several dimensions of a caregiver’s life and potentially causing caregiver burden.
Angelika D. Geerlings, Willanka M. Kapelle, Charlotte J. Sederel, Emma Tenison, Hilde Wijngaards-Berenbroek, Marjan J. Meinders, Marten Munneke, Yoav Ben-Shlomo, Bastiaan R. Bloem, Sirwan K. L. Darweesh   +9 more
doaj   +1 more source