Results 81 to 90 of about 530,549 (345)

Psychiatry beyond the brain: externalism, mental health, and autistic spectrum disorder [PDF]

, 2019
Externalist theories hold that a comprehensive understanding of mental disorder cannot be achieved unless we attend to factors that lie outside of the head: neural explanations alone will not fully capture the complex dependencies that exist between an ...
Glackin, Shane, Krueger, Joel, Roberts, Tom   +2 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Helping children with reading difficulties: some things we have learned so far

npj Science of Learning, 2017
A substantial proportion of children struggle to learn to read. This not only impairs their academic achievement, but increases their risk of social, emotional, and mental health problems.
Genevieve McArthur, Anne Castles
doaj   +1 more source

Cognitive and mood assessment tools for use in stroke [PDF]

, 2018
No abstract ...
Elliott, Emma, Langhorne, Peter, Quinn, Terence J.   +2 more
core   +1 more source

Disorders of Visuo-spatial Cognition

Neurocase, 2005
Disorders of visuo-spatial ...
Humphreys, G, Husain, M, Farné, A, Rorden, C, Bartolomeo, Paolo   +4 more
openaire   +4 more sources

Cognitive style in bipolar disorder [PDF]

British Journal of Psychiatry, 2005
BackgroundAbnormalities of cognitive style in bipolar disorder are of both clinical and theoretical importance.AimsTo compare cognitive style in people with affective disorders and in healthy controls.MethodSelf-rated questionnaires were administered to 118 individuals with bipolar I disorder, 265 with unipolar major recurrent depression and 268 ...
Jones L, Scott J, Haque S, Gordon-Smith K, Heron J, Caesar S, Cooper C, Forty L, Hyde S, Lyon L, Greening J, Sham P, Farmer A, McGuffin P, Jones I, Craddock N   +15 more
openaire   +5 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Increased individual variability in functional connectivity of the default mode network and its genetic correlates in major depressive disorder

Scientific Reports
Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder characterized with considerable individual variability in clinical manifestations which may correspond to brain alterations including the default mode network (DMN).
Chi Yao, Peng Wang, Yang Xiao, Yuhong Zheng, Jiayong Pu, Yongwei Miao, Jinghua Wang, Shao-Wei Xue   +7 more
doaj   +1 more source

Innovative approaches to the study of social phenotypes in neurodevelopmental disorders: an introduction to the research topic [PDF]

, 2013
R01 HD033470 - NICHD NIH ...
Plesa Skwerer, Daniela, Tager-Flusberg, Helen   +1 more
core   +2 more sources