Results 11 to 20 of about 361,832 (264)

T Cells Actively Infiltrate the White Matter of the Aging Monkey Brain in Relation to Increased Microglial Reactivity and Cognitive Decline

Frontiers in Immunology, 2021
Normal aging is characterized by declines in processing speed, learning, memory, and executive function even in the absence of neurodegenerative diseases such as Alzheimer's Disease (AD). In normal aging monkeys and humans, neuronal loss does not account
Katelyn V. Batterman, Payton E. Cabrera, Tara L. Moore, Tara L. Moore, Tara L. Moore, Douglas L. Rosene, Douglas L. Rosene   +6 more
doaj   +1 more source

Age-associated cognitive decline [PDF]

British Medical Bulletin, 2009
Age-associated cognitive decline-or normal (non-pathological, normative, usual) cognitive ageing-is an important human experience which differs in extent between individuals. The determinants of the differences in age-related cognitive decline are not fully understood.
Deary, I. J., Corley, J., Gow, A. J., Harris, Sarah, Houlihan, Lorna, Marioni, Riccardo E, Penke, L., Rafnsson, S. B., Starr, John   +8 more
openaire   +4 more sources

Implementation of the Goal-directed Medication review Electronic Decision Support System (G-MEDSS)© into home medicines review: a protocol for a cluster-randomised clinical trial in older adults

BMC Geriatrics, 2020
Background Older people living in the community have a high prevalence of polypharmacy and are vulnerable to adverse drug events. Home Medicines Review (HMR) is a collaborative medication review service involving general practitioners (GPs), accredited ...
Lisa Kouladjian O’Donnell, Mouna Sawan, Emily Reeve, Danijela Gnjidic, Timothy F. Chen, Patrick J. Kelly, J. Simon Bell, Sarah N. Hilmer   +7 more
doaj   +1 more source

Near-moderate cognitive decline

Неврология, нейропсихиатрия, психосоматика, 2020
Management of patients with cognitive impairment is one of the most relevant and important problems of neurology. It is especially important to identify cognitive impairment at the early (pre-dementia) stages, when appropriate medical measures are ...
N. N. Koberskaya, T. M. Ostroumova
doaj   +1 more source

Adiponectin and Cognitive Decline [PDF]

International Journal of Molecular Sciences, 2020
Adiponectin (ADPN) is a plasma protein secreted by adipose tissue showing pleiotropic effects with anti-diabetic, anti-atherogenic, and anti-inflammatory properties. Initially, it was thought that the main role was only the metabolism control. Later, ADPN receptors were also found in the central nervous system (CNS).
Rizzo Maria Rosaria, Fasano Renata, Paolisso Giuseppe.   +2 more
openaire   +3 more sources

An economic model of advance care planning in Australia: a cost-effective way to respect patient choice

BMC Health Services Research, 2017
Background Advance care planning (ACP) is a process of planning for future health and personal care. A person’s values and preferences are made known so that they can guide decision making at a future time when that person cannot make or communicate his ...
Kim-Huong Nguyen, Marcus Sellars, Meera Agar, Sue Kurrle, Adele Kelly, Tracy Comans   +5 more
doaj   +1 more source

Regional brain atrophy and cognitive decline depend on definition of subjective cognitive decline

NeuroImage: Clinical, 2022
Background: People with subjective cognitive decline (SCD) may be at increased risk for Alzheimer’s disease (AD). However, not all studies have observed this increased risk.
Cassandra Morrison, Mahsa Dadar, Neda Shafiee, Sylvia Villeneuve, D. Louis Collins   +4 more
doaj   +1 more source

Agents of change: establishing quality improvement collaboratives to improve adherence to Australian clinical guidelines for dementia care

Implementation Science, 2018
Background Dissemination of clinical practice guidelines alone is insufficient to create meaningful change in clinical practice. Quality improvement collaborative models have potential to address the evidence-practice gap in dementia care because they ...
Monica Cations, Maria Crotty, Janna Anneke Fitzgerald, Susan Kurrle, Ian D. Cameron, Craig Whitehead, Jane Thompson, Billingsley Kaambwa, Kate Hayes, Lenore de la Perrelle, Gorjana Radisic, Kate E. Laver   +11 more
doaj   +1 more source

SImplification of Medications Prescribed to Long-tErm care Residents (SIMPLER): study protocol for a cluster randomised controlled trial

Trials, 2018
Background Complex medication regimens are highly prevalent in residential aged care facilities (RACFs). Strategies to reduce unnecessary complexity may be valuable because complex medication regimens can be burdensome for residents and are costly in ...
Janet K. Sluggett, Esa Y. H. Chen, Jenni Ilomäki, Megan Corlis, Sarah N. Hilmer, Jan Van Emden, Choon Ean Ooi, Kim-Huong Nguyen, Tracy Comans, Michelle Hogan, Tessa Caporale, Susan Edwards, Lyntara Quirke, Allan Patching, J. Simon Bell   +14 more
doaj   +1 more source

People living in nursing care facilities who are ambulant and fracture their hips: description of usual care and an alternative rehabilitation pathway

BMC Geriatrics, 2020
Background Little is known about treatment provided to people living in nursing care facilities (NCFs) after hospital admission for hip fracture. In addition, there are no clinical guidelines for rehabilitation and recovery following hip fracture for ...
Maggie Killington, Owen Davies, Maria Crotty, Rhiannon Crane, Naomi Pratt, Kylie Mills, Arabella McInnes, Susan Kurrle, Ian D. Cameron   +8 more
doaj   +1 more source