Results 31 to 40 of about 970,204 (258)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Underdiagnosis of mild cognitive impairment: A consequence of ignoring practice effects [PDF]

, 2018
INTRODUCTION: Longitudinal testing is necessary to accurately measure cognitive change. However, repeated testing is susceptible to practice effects, which may obscure true cognitive decline and delay detection of mild cognitive impairment (MCI ...
Chen, Tian, Elman, Jeremy A., Franz, Carol E., Gustavson, Daniel E., Hatton, Sean N., Jacobson, Kristen C., Jak, Amy J., Kremen, William S., Lyons, Michael J., McKenzie, Ruth, Panizzon, Matthew S., Reynolds, Chandra A., Toomey, Rosemary, Tu, Xin M., Xian, Hong   +14 more
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Distinct cytokine profiles across trajectories of self-perceived cognitive impairment among early-stage breast cancer survivors. [PDF]

, 2020
The aim of the current study is to identify distinct cytokine profiles in relation to self-perceived cognitive trajectories. In our study cohort (n = 128), early-stage breast cancer patients were categorized into no impairment reported, acute ...
Chan, Alexandre, Ho, Han Kiat, Toh, Yi Long, Wang, Claire   +3 more
core   +1 more source

Social activity, cognitive decline and dementia risk: a 20-year prospective cohort study. [PDF]

, 2015
BACKGROUND: Identifying modifiable lifestyle correlates of cognitive decline and risk of dementia is complex, particularly as few population-based longitudinal studies jointly model these interlinked processes. Recent methodological developments allow us
Amieva, Helene, Brayne, Carol, Dartigues, Jean-Francois, Jacqmin-Gadda, Helene, Marioni, Riccardo E, Matthews, Fiona E, Proust-Lima, Cecile   +6 more
core   +3 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

The Contribution of Blood Serum Biomarkers to the Prediction of Cognitive Decline by fMRI and Apolipoprotein-E in Healthy Older Adults [PDF]

, 2012
Biomarkers are a promising approach to the prediction and early intervention of Alzheimer\u27s disease. We demonstrated that cortical functional MRI (fMRI) activation during a semantic memory task and apolipoprotein-E ?4 allele inheritance (APOE?4 ...
Durgerian, Sally, Nielson, Kristy A., Rao, Stephen M., Seidenberg, Michael, Smith, J. Carson, Sugarman, Michael, Woodard, John L.   +6 more
core   +2 more sources

Tau and atrophy: domain-specific relationships with cognition. [PDF]

, 2019
BackgroundLate-onset Alzheimer's disease (AD) is characterized by primary memory impairment, which then progresses towards severe deficits across cognitive domains.
Alzheimer’s Disease Neuroimaging Initiative, Banks, Sarah J, Brewer, James B, Dale, Anders M, Digma, Leonardino A, Madsen, John R, Reas, Emilie T   +6 more
core  

Aging, Cognitive Decline and Hearing Loss: Effects of Auditory Rehabilitation and Training with Hearing Aids and Cochlear Implants on Cognitive Function and Depression among Older Adults [PDF]

, 2016
A growing interest in cognitive effects associated with speech and hearing processes is spreading throughout the scientific community essentially guided by evidence that central and peripheral hearing loss is associated with cognitive decline.
Benatti, Alice, Bovo, Roberto, Castiglione, Alessandro, Favaro, Diego, Gabelli, Carlo, Martini, Alessandro, Padoan, Elisa, Pagliaro, Michela, Severi, Daniele, Vallesi, Antonino, Velardita, Carmelita   +10 more
core   +1 more source

CKD Associates with Cognitive Decline [PDF]

Journal of the American Society of Nephrology, 2009
Cognitive impairment and chronic kidney disease (CKD) will become increasingly prevalent in the aging US population. Although evidence exists that CKD is a risk factor for cognitive decline, longitudinal studies are limited and largely have excluded ethnically diverse populations.
Minesh, Khatri, Thomas, Nickolas, Yeseon P, Moon, Myunghee C, Paik, Tatjana, Rundek, Mitchell S V, Elkind, Ralph L, Sacco, Clinton B, Wright   +7 more
openaire   +2 more sources