Results 21 to 30 of about 970,204 (258)
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Achieving and Maintaining Cognitive Vitality With Aging [PDF]
, 2001 This report contains the summary results of a workshop held at Canyon Ranch Health Resort in Tucson, Arizona. Physicians and scientists shed light on the process of cognitive aging.
Howard Fillit, Robert N. Butler
core
Prediction of Cognitive Decline in Healthy Older Adults using fMRI [PDF]
, 2010 Few studies have examined the extent to which structural and functional MRI, alone and in combination with genetic biomarkers, can predict future cognitive decline in asymptomatic elders.
Antuono, Piero +11 more
core +2 more sources
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Thromboprophylaxis in atrial fibrillation and association with cognitive decline: systematic review [PDF]
, 2016 Objective:Atrial Fibrillation (AF) is associated with dementia. If AF-related cognitive decline is driven by cerebral embolic events, thromboprophylaxis may impact on this.
Lane, Deirdre A. +4 more
core +2 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Job-worker Mismatch and Cognitive Decline [PDF]
We use longitudinal test data on various aspects of persons’ cognitive abilities to analyze whether overeducated workers are more vulnerable to cognitive decline, and undereducated workers are less vulnerable. We find that the job-worker mismatch induces
Bosma,Hans +3 more
core +4 more sources
Diagnosis in vascular dementia, applying ‘Cochrane diagnosis rules’ to ‘dementia diagnostic tools’ [PDF]
, 2017 In this issue of Clinical Science, Biesbroek and colleagues describe recent work on magnetic resonance imaging (MRI)-based cerebral lesion location and its association with cognitive decline.
McCleery, Jenny, Quinn, Terence J.
core +1 more source
Postoperative Cognitive Decline [PDF]
American Journal of Biomedical Science & Research, 2019 Due to a combination of advancing medical technology and the increasing age of the adult population, more adults are pursuing surgical intervention, particularly elective surgery, than ever before. Postoperative cognitive decline (POCD) describes either a transient or chronic change in cognitive function that comes as a result of anesthesia or surgical
Dawson Hedges +3 more
openaire +2 more sources