Results 11 to 20 of about 970,204 (258)
Cognition Enhancers in Age-Related Cognitive Decline [PDF]
Drugs & Aging, 1996 A review of recently published studies on the effect of cognition enhancers in non-demented human study participants is presented. The heterogeneity of the therapeutic target, age-associated cognitive decline, can be improved by separately treating groups in whom age-extrinsic factors may underlie cognitive pathology.
Riedel, Wim J., Jolles, Jellemer
openaire +3 more sources
Determinants of Activity Levels in African Americans With Mild Cognitive Impairment. [PDF]
, 2016 Engaging in cognitive, social, and physical activities may prevent cognitive decline. In a sample of older African Americans with mild cognitive impairment (MCI; N=221), we investigated the cross-sectional relationships between activity levels and ...
Casten, PhD, Robin J. +2 more
core +2 more sources
Macrophages come to mind as keys to cognitive decline [PDF]
, 2016 Cognitive impairment, an underappreciated consequence of hypertension, is linked to cerebral arteriolar disease through poorly defined mechanisms. A study by Faraco et al.
D.G. Harrison +5 more
core +1 more source
Cognition: The brain's decline [PDF]
Nature, 2012 Treating cognitive problems common in elderly people requires a deeper understanding of how a healthy brain ages.
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Gait and cognition: mapping the global and discrete relationships in ageing and neurodegenerative disease [PDF]
, 2016 Recent research highlights the association of gait and cognition in older adults but a stronger understanding is needed to discern coincident pathophysiology, patterns of change, examine underlying mechanisms and aid diagnosis.
Bunce, Jennifer +4 more
core +2 more sources
Hypertension and cognitive decline [PDF]
British Journal of Psychiatry, 1999 Significant associations have been reported between cognitive decline, dementia and measures of cardiovascular and cerebrovascular disease. Such findings raise important possibilities for prevention of dementia through reducing the burden of vascular pathology.
openaire +2 more sources
Explicit and Implicit Memory Loss in Aging [PDF]
, 2018 How our memory is affected as we age has been given considerable attention over recent decades as we strive to understand the cognitive processes involved.
Alexander, Victoria +2 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source