Results 51 to 60 of about 401,594 (264)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Assessment of Dementia in Individuals with Dual Sensory Loss: Application of a Tactile Test Battery

Dementia and Geriatric Cognitive Disorders Extra, 2018
Background/Aims: Individuals with dual sensory loss (DSL) are more likely to experience cognitive decline with age than individuals without sensory loss.
Peter Bruhn, Jesper Dammeyer
doaj   +1 more source

Insidious Cognitive Decline in CADASIL [PDF]

Stroke, 2004
Background and Purpose— Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) causes repeated ischemic attacks leading to subcortical vascular dementia.
Kaarina, Amberla, Minna, Wäljas, Susanna, Tuominen, Ove, Almkvist, Minna, Pöyhönen, Seppo, Tuisku, Hannu, Kalimo, Matti, Viitanen   +7 more
openaire   +2 more sources

Stage-Dependent β-Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ay U, Alaylioglu M, Sahin E, Oner SSY, Iskan G, Cakan GCY, Kizilates-Evin G, Hari E, Kurt E, Dursun E, Bilgic B, Hanagasi H, Gurvit H, Demiralp T, Gezen-Ak D, Samanci B.   +15 more
europepmc   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study

Chinese Medical Journal, 2018
Background: Memory complaint is common in the elderly. Recently, it was shown that self-report memory complaint was predictive of cognitive decline. This study aimed to investigate the predictive value of the source of memory complaints on the risk of ...
Xue-Mei Qi, Lin Gu, Hui-Dong Tang, Sheng-Di Chen, Jian-Fang Ma   +4 more
doaj   +1 more source

NEUROLOGICAL AND COGNITIVE DECLINE IN ADOLESCENCE [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2003
The evaluation of progressive neurological and/or cognitive decline poses one of the greatest challenges to the paediatric neurologist. While the potential causes are individually quite rare, collectively neurodegenerative disorders are quite common with an incidence of approximately 0.5/1000 live births.1 Faced with an individual child, it is easy to ...
openaire   +3 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Study partner‐reported decline identifies cognitive decline and dementia risk

Annals of Clinical and Translational Neurology, 2019
Objective Identifying individuals at risk for cognitive decline, Mild Cognitive Impairment (MCI), and dementia due to Alzheimer’s disease (AD) is a critical need.
Rachel L. Nosheny, Chengshi Jin, John Neuhaus, Philip S. Insel, Robert Scott Mackin, Michael W. Weiner, Alzheimer’s Disease Neuroimaging Initiative investigators   +6 more
doaj   +1 more source