Results 201 to 210 of about 335,081 (290)

Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy

open access: yesAdvanced Science, EarlyView.
This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou   +13 more
wiley   +1 more source

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

open access: yesAdvanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu   +12 more
wiley   +1 more source

Training‐Free Regulation of Grasping by Intracortical Tactile Feedback Designed via S1‐M1 Communication

open access: yesAdvanced Science, EarlyView.
During object grasping in macaques, information flow between the primary sensory cortex (S1) and the primary motor cortex (M1) is modulated by tactile properties of the target. Intracortical micro‐stimulation in S1 reliably evokes M1 responses that resemble those naturally generated during grasping under specific tactile conditions.
Qi Zhang   +9 more
wiley   +1 more source

Four questions to predict cognitive decline in de novo Parkinson's disease. [PDF]

open access: yesNPJ Parkinsons Dis
Hlavnička J   +9 more
europepmc   +1 more source

Tricyclic Antidepressants and Cognitive Decline

open access: bronze, 2002
Laura Jean Podewils   +1 more
openalex   +1 more source

Vision Impairment and Combined Vision and Hearing Impairment Predict Cognitive and Functional Decline in Older Women [PDF]

open access: green, 2004
Michael Lin   +8 more
openalex   +1 more source

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