Results 41 to 50 of about 361,832 (264)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba +11 more
wiley +1 more source
Translational Psychiatry, 2022 Cognitive decline is part of the normal aging process. However, some people experience a more rapid decline than others due to environmental and genetic factors.
M. Liset Rietman +11 more
doaj +1 more source
Cognitive Decline Assessment: A Review From Medical Imaging Perspective
Frontiers in Aging Neuroscience, 2021 Aging is a complex process that involves changes at both molecular and morphological levels. However, our understanding of how aging affects brain anatomy and function is still poor.
Caroline Machado Dartora +6 more
doaj +1 more source
Postoperative Cognitive Decline [PDF]
American Journal of Biomedical Science & Research, 2019 Due to a combination of advancing medical technology and the increasing age of the adult population, more adults are pursuing surgical intervention, particularly elective surgery, than ever before. Postoperative cognitive decline (POCD) describes either a transient or chronic change in cognitive function that comes as a result of anesthesia or surgical
Dawson Hedges +3 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
CKD Associates with Cognitive Decline [PDF]
Journal of the American Society of Nephrology, 2009 Cognitive impairment and chronic kidney disease (CKD) will become increasingly prevalent in the aging US population. Although evidence exists that CKD is a risk factor for cognitive decline, longitudinal studies are limited and largely have excluded ethnically diverse populations.
Minesh, Khatri +7 more
openaire +2 more sources
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Cardiovascular Prevention of Cognitive Decline
Cardiology Research and Practice, 2011 Midlife cardiovascular risk factors, including diabetes, hypertension, dyslipemia, and an unhealthy lifestyle, have been linked to subsequent incidence, delay of onset, and progression rate of Alzheimer disease and vascular dementia.
Jean-Jacques Monsuez +2 more
doaj +1 more source