Results 41 to 50 of about 965,316 (341)

Demand Coupling Drives Neurodegeneration: A Model of Age-Related Cognitive Decline and Dementia

Cells, 2022
The societal burden of Alzheimer’s Disease (AD) and other major forms of dementia continues to grow, and multiple pharmacological agents directed towards modifying the pathological “hallmarks” of AD have yielded disappointing results.
Josh Turknett, Thomas R. Wood
doaj   +1 more source

Effects of non-pharmacological or pharmacological interventions on cognition and brain plasticity of aging individuals. [PDF]

, 2014
Brain aging and aging-related neurodegenerative disorders are major health challenges faced by modern societies. Brain aging is associated with cognitive and functional decline and represents the favourable background for the onset and development of ...
Cesinaro, Stefano, Esposito, Roberto, Frazzini, Valerio, Pieramico, Valentina, Sensi, Stefano L   +4 more
core   +2 more sources

Onset of Mild Cognitive Impairment in Parkinson Disease [PDF]

, 2016
Objective: Characterize the onset and timing of cognitive decline in Parkinson disease (PD) from the first recognizable stage of cognitively symptomatic PD-mild cognitive impairment (PD-MCI) to PD dementia (PDD).
Barton, Biundo, Botwinick, Broeders, Cholerton, Cudeck, Dubois, Duncombe, Emre, Galvin, Galvin, Geurtsen, Goldman, Goldman, Hughes, Jack, Johnson, Johnson, Johnson, Lippa, Litvan, Marinelli, Marinelli, Morris, Muslimovic, Muslimovic, Pate, Petersen, Price, Reid, Slate, Stewart, Troncoso, Wang, Yarnall   +34 more
core   +2 more sources

Probable Early-Onset Alzheimer's Disease in an Apolipoprotein E2 Homozygote [PDF]

, 2010
Objective: To describe a case of early-onset Alzheimer's disease (AD) in an apolipoprotein (Apo) epsilon 2/epsilon 2 homozygote. Background: Apo epsilon 2/epsilon 2 is the rarest of the ApoE genotypes, representing only 1.4% of the population.
Belden, Christine, Berk, Camryn, Cole, Lauren, Jacobson, Sandra, Liebsack, Carolyn, Myers, Kent, Reninger, Cornelia, Sabbagh, Marwan N.   +7 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Process outcomes of a multifaceted, interdisciplinary knowledge translation intervention in aged care: results from the vitamin D implementation (ViDAus) study

BMC Geriatrics, 2019
Background Vitamin D supplement use is recommended best practice in residential aged care facilities (RACFs) for the prevention of falls, however has experienced delays in uptake.
Pippy Walker, Annette Kifley, Susan Kurrle, Ian D. Cameron   +3 more
doaj   +1 more source

Is comprehensiveness critical? Comparing short and long format cognitive assessments in preclinical Alzheimer disease

Alzheimer’s Research & Therapy, 2021
Background Comprehensive testing of cognitive functioning is standard practice in studies of Alzheimer disease (AD). Short-form tests like the Montreal Cognitive Assessment (MoCA) use a “sampling” of measures, administering key items in a shortened ...
Jason Hassenstab, Jessica Nicosia, Megan LaRose, Andrew J. Aschenbrenner, Brian A. Gordon, Tammie L. S. Benzinger, Chengjie Xiong, John C. Morris   +7 more
doaj   +1 more source

Cognitive Decline Assessment: A Review From Medical Imaging Perspective

Frontiers in Aging Neuroscience, 2021
Aging is a complex process that involves changes at both molecular and morphological levels. However, our understanding of how aging affects brain anatomy and function is still poor.
Caroline Machado Dartora, Wyllians Vendramini Borelli, Wyllians Vendramini Borelli, Michel Koole, Ana Maria Marques da Silva, Ana Maria Marques da Silva, Ana Maria Marques da Silva   +6 more
doaj   +1 more source

Episodic Memory Measures Complement Structural and Functional MRI for Predicting Cognitive Decline in Apolipoprotein E ε4 Carriers [PDF]

, 2012
Apolipo-protein E (APOE) ?4 allele carriers demonstrate greater risk for cognitive decline and Alzheimer\u27s disease than non-carriers. However, factors associated with risk of decline among APOE ?4 carriers are not well-known.
Butts, Alissa, Durgerian, Sally, Foster, Mary K., Hantke, Nathan, Lancaster, Melissa A., Matthews, Monica, Nielson, Kristy A., Rao, Stephen M., Seidenberg, Michael, Smith, J. Carson, Sugarman, Michael, Woodard, John L.   +11 more
core   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source