Results 51 to 60 of about 2,883,132 (337)

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

Nature, 2020
Vascular contributions to dementia and Alzheimer’s disease are increasingly recognized1–6. Recent studies have suggested that breakdown of the blood–brain barrier (BBB) is an early biomarker of human cognitive dysfunction7, including the early clinical ...
Axel Montagne, D. Nation, A. Sagare, G. Barisano, Melanie D. Sweeney, Ararat Chakhoyan, M. Pachicano, Elizabeth Joe, Amy R. Nelson, Lina M. D’Orazio, David P. Buennagel, M. Harrington, T. Benzinger, A. Fagan, J. Ringman, L. Schneider, J. Morris, E. Reiman, R. Caselli, H. Chui, J. Tcw, Yining Chen, J. Pa, P. Conti, Meng Law, A. Toga, B. Zlokovic   +26 more
semanticscholar   +1 more source

Cognitive visual dysfunction. [PDF]

British Journal of Ophthalmology, 1994
infarctionresultsinatriadofdisorders.(1) Simultanagnosiainwhichthepatientis neitherabletotakeinterestin,nortobeawareofobjectslyingoneithersideoftheobjectofregard,despitetherequisitevisualacuityandintactvisualfields forthatarea.(2) Psychicparalysisofgazeoccursinwhichthecognitivefield ofview is apparently restricted to being only able ...
openaire   +3 more sources

Metformin therapy and cognitive dysfunction in patients with type 2 diabetes

Medicine, 2020
Background: Type 2 diabetes (T2D) is a risk factor for cognitive dysfunction. The relationship between metformin therapy and cognitive function in patients with T2D is unknown.
Qing-qing Zhang, Wen-shan Li, Zhou Liu, Hui-li Zhang, Ying Ba, Rui-Xia Zhang   +5 more
semanticscholar   +1 more source

Salidroside alleviates ferroptosis of retinal ganglion cells in db/db mice

Food Science and Human Wellness
Salidroside (Sal), is one of the important food supplements from the traditional Chinese medicine Integripetal rhodiola herb, encapsulating significant anti-oxidative stress, anti-ferroptosis, and neuroprotective attributes.
Wenqiang Liu, Anqi Liu, Yufei Wang, Shengxue Yu, Chuang Feng, Wanpeng Liu, Yan Fang, Jing Li, Hongdan Yu, Jiayou Liu, Wenjuan Wang, Jiayuan Ding, Pan Lü, Lipan Zhao, Linqin Luo, Xuezheng Liu, Zhongfu Zuo   +16 more
doaj   +1 more source

Postoperative Cognitive Dysfunction

Open Access Indonesian Journal of Medical Reviews, 2021
The impact of general anesthesia on cognitive impairment is controversial and complex. A large body of evidence supports the association between exposure to surgery under general anesthesia and the development of delayed neurocognitive recovery in a subset of patients.
openaire   +2 more sources

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

GLCCI1 alleviates GRP78-initiated endoplasmic reticulum stress-induced apoptosis of retinal ganglion cells in diabetic retinopathy by upregulating and interacting with HSP90AB1

Scientific Reports
Retinal ganglion cells (RGCs) are among the first neurons to undergo apoptosis in diabetic retinopathy (DR), with their relationship to endoplasmic reticulum stress (ERS)-induced apoptosis still unclear. While glucocorticoid-induced transcript 1 (GLCCI1)
Jiayou Liu, Hongdan Yu, Shengxue Yu, Mengren Liu, Xinyuan Chen, Yufei Wang, Jing Li, Caixing Shi, Wenqiang Liu, Zhongfu Zuo, Xuezheng Liu   +10 more
doaj   +1 more source

A study to evaluate the relationship between diabetes mellitus and cognitive dysfunction

Asian Journal of Medical Sciences, 2022
Background: Diabetes mellitus (DM) is the most common endocrine disorder. It leads to slow progressive end-organ damage (both microvascular and macrovascular). The cognitive dysfunction is a less known and less addressed complication of DM.
Rakesh Kumar Patel , Karan Saran Kapur , Sardar Eske   +2 more
doaj   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source