Results 51 to 60 of about 339,240 (318)

Salidroside protects RGC from pyroptosis in diabetes-induced retinopathy associated with NLRP3, NFEZL2 and NGKB1, revealed by network pharmacology analysis and experimental validation

European Journal of Medical Research
Objective To investigate the effect of salidroside (SAL) in protecting retinal ganglion cell (RGC) from pyroptosis and explore associated molecular network mechanism in diabetic retinapathy (DR) rats.
Lan-Chun Zhang, Na Li, Min Xu, Ji-Lin Chen, Hua He, Jia Liu, Ting-Hua Wang, Zhong-Fu Zuo   +7 more
doaj   +1 more source

Dysfunction of EAAT3 Aggravates LPS-Induced Post-Operative Cognitive Dysfunction

Membranes, 2022
Numerous results have revealed an association between inhibited function of excitatory amino acid transporter 3 (EAAT3) and several neurodegenerative diseases.
Xiao-Yan Wang, Wen-Gang Liu, Ai-Sheng Hou, Yu-Xiang Song, Yu-Long Ma, Xiao-Dong Wu, Jiang-Bei Cao, Wei-Dong Mi   +7 more
doaj   +1 more source

fMRI-based Static and Dynamic Functional Connectivity Analysis for Post-stroke Motor Dysfunction Patient: A Review [PDF]

arXiv, 2022
Functional magnetic resonance imaging (fMRI) has been widely utilized to study the motor deficits and rehabilitation following stroke. In particular, functional connectivity(FC) analyses with fMRI at rest can be employed to reveal the neural connectivity rationale behind this post-stroke motor function impairment and recovery.
arxiv  

Postoperative delirium and cognitive dysfunction [PDF]

British Journal of Anaesthesia, 2009
Postoperative delirium and cognitive dysfunction (POCD) are topics of special importance in the geriatric surgical population. They are separate entities, whose relationship has yet to be fully elucidated. Although not limited to geriatric patients, the incidence and impact of both are more profound in geriatric patients.
Stacie Deiner, Jeffrey H. Silverstein
openaire   +3 more sources

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source

Functional Connectivity Dynamics show Resting-State Instability and Rightward Parietal Dysfunction in ADHD [PDF]

arXiv, 2023
Attention Deficit/Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders in children and is characterised by inattention, impulsiveness and hyperactivity. While several studies have analysed the static functional connectivity in the resting-state functional MRI (rs-fMRI) of ADHD patients, detailed investigations are ...
arxiv  

Cannabis use and cognitive dysfunction

Indian Journal of Psychiatry, 2011
Byline: Amresh. Shrivastava, Megan. Johnston, Ming. Tsuang This review considers the effects of cannabis on cognitive functioning, in both short and long term. Although the general impression supported by many studies is that cannabis causes cognitive decline, particularly with long-term usage, some research suggests that this may not be the case ...
Amresh Shrivastava, Megan Johnston, Ming T. Tsuang   +2 more
openaire   +3 more sources

Relationship of cognitive decline with glucocerebrosidase activity and amyloid‐beta 42 in DLB and PD

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Dementia with Lewy bodies (DLB) and Parkinson's disease (PD) share clinical, pathological, and genetic risk factors, including GBA1 and APOEε4 mutations. Biomarkers associated with the pathways of these mutations, such as glucocerebrosidase enzyme (GCase) activity and amyloid‐beta 42 (Aβ42) levels, may hold potential as predictive ...
Maria Camila Gonzalez, Linn Oftedal, Johannes Lange, Diego Alejandro Tovar‐Rios, Ole‐Bjørn Tysnes, Claire Paquet, Marta Marquié, Mercè Boada, Daniel Alcolea, Konrad Rejdak, Ewa Papuc, Jakub Hort, Cristian Falup‐Pecurariu, Dag Aarsland, Guido Alves, Jodi Maple‐Grødem   +15 more
wiley   +1 more source

Cardiac dysfunction and cognitive decline [PDF]

European Heart Journal, 2017
This editorial refers to ‘Associations between single and multiple cardiometabolic disease and cognitive abilities in 14 129 UK Biobank participants’, by D. Lyall et al. doi:10.1093/eurheartj/ehw528. The Ebers papyrus dating back to ∼1550 BC contains a treatise on the heart where it refers to this organ as the centre of the body’s blood supply.1 ...
openaire   +3 more sources

Skin calcium deposits in primary familial brain calcification: A novel potential biomarker

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Primary Familial Brain Calcification (PFBC) is a rare neurodegenerative disorder characterized by small vessel calcifications in the basal ganglia. PFBC is caused by pathogenic variants in different genes and its physiopathology is still largely unknown. Skin vascular calcifications have been detected in single PFBC cases, suggesting
Aron Emmi, Giulia Bonato, Aleksandar Tushevski, Cinzia Bertolin, Francesco Cavallieri, Andrea Porzionato, Angelo Antonini, Leonardo Salviati, Miryam Carecchio   +8 more
wiley   +1 more source