Results 91 to 100 of about 1,931,867 (302)

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

The flexibility and reversibility of cognitive frailty [PDF]

Alzheimer's & Dementia, 2020
AbstractBackgroundDeclining physical and cognitive functioning play critical roles in ageing. Cognitive frailty is a concurrent physical and cognitive decline condition. We defined cognitive frailty as dynapenia concomitant with impairment in any cognitive domain, but without dementia.
openaire   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Frailty in survival analysis models (parametric frailty, parametric shared frailty, and frailty in Cox models [PDF]

Frailty models are used to model survival times in the presence of overdispersion or group-specific random effects. The latter are distinguished from the former by the term "shared" frailty models.
Roberto G. Gutierrez
core  

Cognitive frailty: A scoping review protocol

, 2022
This study aimed to explore the risk factors and protective factors associated with cognitive frailty among community-dwelling older adults, and to provide the impact of cognitive frailty on health-related ...
JuHee Lee, Sumi LEE
core   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Informal care and cognitive frailty among Chinese older adults: the mediating role of social participation

BMC Geriatrics
Background and Objectives With the intensification of ageing, cognitive frailty has become a major public health issue. The underlying mechanisms of the association between informal care and cognitive frailty were poorly understood.
Tianyu Gao, Dan Zhao, Shujun Chai, Xiaohan Qi, Yang Liu, Yihong Sun, Yuxun Zhang, Zihan Lin, Jie Zhou, Chengchao Zhou   +9 more
doaj   +1 more source

Goodness-of-fit tests for the frailty distribution in proportional hazards models with shared frailty. [PDF]

Frailty models account for the clustering present in grouped event time data. A proportional hazards model with shared frailties expresses the hazard for each subject. Often a one-parameter gamma distribution is assumed for the frailties. The choice of a
Claeskens, Gerda, Janssen, Paul, Geerdens, Candida   +2 more
core  

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Association Between the Color Kanji Pick-Out Test App Performance and Cognitive Frailty as a Potential Early Screening Marker for Cognitive Decline

Geriatrics
Background/Objective: Cognitive frailty, the coexistence of physical frailty and cognitive impairment, is a potentially reversible and high-risk state for dementia.
Akio Goda, Hideki Nakano, Yuki Kikuchi, Tsuyoshi Katsurasako, Kohei Mori, Atsuko Kubo, Kayoko Nonaka, Kohei Iwamoto, Nozomi Mitsumaru, Takaki Shimura, Shin Murata   +10 more
doaj   +1 more source