Results 101 to 110 of about 1,931,867 (302)

An Expertise Transfer Framework For Autonomous Surgical Assistance

open access: yesAdvanced Science, EarlyView.
This study introduces an expertise transfer framework for procedure‐spanning autonomous surgical assistance. By emulating expert logic through hierarchical perception, attention modeling, and knowledge graph‐based decision‐making, the system provides near‐expert surgical view assistance.
Yuan Gao   +12 more
wiley   +1 more source

Mediating effect of social frailty on oral frailty and cognitive function in older adults: a cross-sectional study in a rural Chinese community

open access: yesFrontiers in Aging Neuroscience
BackgroundCognitive function has been associated with both social and oral frailty. However, few studies have explored how social frailty and oral frailty jointly relate to cognitive function.
Zhiyue Jiang   +7 more
doaj   +1 more source

A scoping review about cognitive frailty

open access: yes, 2021
This study aimed to explore the risk factors and protective factors associated with cognitive frailty among community-dwelling older adults, and to provide the impact of cognitive frailty on health-related ...
Sumi LEE
core   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

open access: yesAdvanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji   +11 more
wiley   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu   +15 more
wiley   +1 more source

Cognitive frailty [PDF]

open access: yesThe Journal of nutrition, health and aging, 2013
A S, Buchman, D A, Bennett
openaire   +2 more sources

THE INFLUENCE OF LIFESTYLE BEHAVIORS ON THE INCIDENCE OF FRAILTY

open access: yes, 2020
BACKGROUND: Frailty is a clinical state defined as an increase in an individual’s vulnerability to developing adverse health-related outcomes. OBJECTIVES: We propose that healthy behaviors could lower the incidence of frailty.
AVILA-FUNES, J.A.   +11 more
core   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

open access: yesAGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Frailty and Cognitive Impairment in ESRD [PDF]

open access: yesClinical Journal of the American Society of Nephrology, 2015
More than 50 years after Belding Scribner and colleagues made maintenance hemodialysis feasible for treatment of ESRD, it is easy to lose sight of the key role of rehabilitation in the care of ESRD patients that Dr.
openaire   +2 more sources

One‐Year Changes in Frailty Components After Curative Minimally Invasive Surgery for Colorectal Cancer in Older Patients

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Frailty predicts outcomes after colorectal cancer surgery, but postoperative changes remain unclear. We previously reported improvement in FRAIL Scale‐based frail/pre‐frail status 1 year after curative minimally invasive surgery (MIS).
Hajime Ushigome   +9 more
wiley   +1 more source

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