Results 121 to 130 of about 1,931,867 (302)

Associations between reversible and potentially reversible cognitive frailty and falls in community-dwelling older adults in China: a longitudinal study

BMC Geriatrics
Background Few studies have focused on comparing the effect of cognitive frailty (CF) with either cognitive impairment or frailty alone on fall risk.
Xiaonuo Xu, Ning Ding, Jing He, Ronghui Zhao, Weiqi Gu, Xiaoyan Ge, Kai Cui   +6 more
doaj   +1 more source

Association of sleep duration and sleep quality with cognitive frailty in Chinese older adults

Frontiers in Public Health
ObjectiveTo explore the relationship between sleep duration, sleep quality and the occurrence of cognitive frailty in the older adults.MethodsA total of 9,970 participates were screened in China over the past 9 years.
Jinqiang Qian, Xin Yu, Qiang Zhang
doaj   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Establishing Biological Plausibility for Cognitive Frailty [PDF]

, 2017
Cognitive frailty is considered a potentially reversible age-related condition characterized by the simultaneous presence of both physical frailty and cognitive decline.
Sargent, Lana Jean
core  

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

The Effect of Young People–Assisted, Individualized, Motion-Based Video Games on Physical, Cognitive, and Social Frailty Among Community-Dwelling Older Adults With Frailty: Randomized Controlled Trial [PDF]

BackgroundThe aging population highlights the need to maintain both physical and psychological well-being. Frailty, a multidimensional syndrome, increases vulnerability to adverse outcomes.
Chow, Karen Kit Sum, Siu Man Wong, Liu, Bob Chung Man, Kowatsch, Tobias; id_orcid, David Chi Ho Lau, Jonathan Bayuo, Zhang, Melissa Qian, Bob Chung Man Liu, Wong, Siu Man, Wong, Arkers Kwan Ching, Wong, Bonnie Po, Kowatsch, Tobias, Tobias Kowatsch, Arkers Kwan Ching Wong, Melissa Qian Zhang, Lau, David Chi Ho, Bayuo, Jonathan, Karen Kit Sum Chow, Bonnie Po Wong   +18 more
core   +1 more source

Accelerated Brain Atrophy in Epilepsy: A Prospective Population‐Based Study

Annals of Neurology, EarlyView.
Objective Previous longitudinal neuroimaging studies suggest that epilepsy is a progressive disorder. To date, these findings have relied largely on populations from tertiary centers, resulting in ascertainment bias, as severely affected individuals are more likely to be rescanned.
Marian Galovic, Rebecca S. N. Liu, Alex D. Everitt, Robert Terziev, Louis Lemieux, Matthias J. Koepp, John S. Duncan   +6 more
wiley   +1 more source

Evolution and interrelation of physical frailty and mild cognitive impairment up to two years after kidney transplantation: a multi-center prospective cohort study

Transplant International
Kidney transplantation (KT) is the preferred treatment for kidney failure, providing superior survival and quality of life compared with haemodialysis. However, the demand for transplantation exceeds organ availability, underscoring the need to optimize ...
Nadine Beerli, Nadine Beerli, Manuel Wehrle, Isabelle Binet, Michael Dickenmann, Déla Golshayan, Karine Hadaya, Uyen Huynh-Do, Reto W. Kressig, Sabina De Geest, Sabina De Geest, Oliver Mauthner, Oliver Mauthner   +12 more
doaj   +1 more source