Results 131 to 140 of about 1,931,867 (302)

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Defining Biomarkers of Frailty in the Kidney: Implications for Endobiotic and Xenobiotic Metabolism in Mice

, 2023
Frailty describes individuals with increased susceptibility to adverse health outcomes. The frailty index (FI) quantifies frailty by measuring deficit accumulation. This project aimed to characterize the molecular signature of frailty in the mouse kidney
Hodgins, Maddison
core  

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug‐metabolizing capacity are not routinely ...
Louise Westberg Strejby Christensen, Anne Kirstine Boas, Emilie Clausen, Nicoline Elers Koch, Anne Byriel Walls, Lotte Stig Nørgaard, Michael Asger Andersen, Anissa Aharaz, Rikke Lundsgaard Nielsen, Olivia Bornæs, Juliette Tavenier, Baker Nawfal Jawad, Helle Gybel Juul‐Larsen, Esben Iversen, Ove Andersen, Lona Louring Christrup, Kim Peder Dalhoff, Morten Baltzer Houlind   +17 more
wiley   +1 more source

Association between frailty and cognitive function: a pooled analysis of three ageing cohorts

Translational Psychiatry
Cross-sectional evidence suggested that frailty was an important risk factor for cognitive impairment. However, previous studies only focused on baseline frailty status, not taking into consideration the dynamic changes in frailty status during follow-up.
Xiangyu Zhang, Yacong Bo, Zeyang Li, Yi Xu, Jing Wang, Xiaoyu Wang, Huanhuan Zhang, Junxi Zhang, Jia Huang, Yuchang Tao, Zengli Yu, Hongyan Liu   +11 more
doaj   +1 more source

Comparing Virtual and Center Based Cardiac Rehabilitation on Changes in Frailty

, 2022
This is a paper-based thesis, however, the manuscript (Chapter 4) has not been submitted to an academic journal at the time of submitting this thesis.Cardiac rehabilitation (CR) is the gold standard for the secondary prevention of cardiovascular disease (
MacEachern, Evan
core  

‘School is their whole world’: Teachers' perspectives on loneliness among children and adolescents from England and mainland China

British Educational Research Journal, EarlyView.
Abstract As front‐line observers and active participants in pupils' daily lives, teachers closely monitor pupils' social interactions, emotional states and behavioural changes. Their unique perspective enables them to detect problems in the social lives of their pupils that may not be immediately visible to peers, parents or mental health professionals.
Yixuan Zheng, Charlotte Bagnall, Caroline Bond, Elizabeth Birchinall, Pamela Qualter   +4 more
wiley   +1 more source

Dementia and Cognitive Frailty

Summary: This chapter explores dementia and cognitive frailty – a syndrome of combined cognitive and physical impairments distinct from dementia – and their relationship to social inequalities in the North compared with the rest of England.
Swarbrick, Caroline, Holland, Carol, Castellani, Brian, Clarke, Charlotte, Zihachi, Mohaddeseh, Clarkson, Daniel   +5 more
core   +3 more sources

CFAI-Plus : adding cognitive frailty as a new domain to the comprehensive frailty assessment instrument

, 2018
: Objectives Cognitive frailty is characterized by the presence of cognitive impairment in exclusion of dementia. In line with other frailty domains, cognitive frailty is associated with negative outcomes. The Comprehensive Frailty Assessment Instrument (
Maria Bjerke, Liesbeth De Donder, Eva Dierckx, Engelborghs, Sebastiaan, De Witte, Nico, De Donder, Liesbeth, Sebastiaan Engelborghs, Sarah Dury, Nico De Witte, De Deyn, Peter Paul, Ellen Elisa De Roeck, Dury, Sarah, De Roeck, Ellen, Bjerke, Maria, Dierckx, Eva, Peter Paul De Deyn   +15 more
core   +1 more source

Probiotic spore‐based bioresponsive drug delivery for reversing inflammatory bowel disease and its associated anxiety and depression

BMEMat, EarlyView.
A probiotic spore‐based drug delivery system (BCS‐Que@ApNPs) provides excellent targeted delivery, bioresponsive drug release, and long‐term retention (over 48 h), making it suitable for oral treatment of inflammatory bowel disease and its associated anxiety and depression.
Qingling Song, Beiyang Xue, Yao Li, Chuangxi Zhou, Junfei Yang, Yunfei Li, Lingwen Ding, Yun Zhang, Hongjuan Zhao, Lei Wang   +9 more
wiley   +1 more source

From Material Tensions to Organizational Paradoxes: How Manufacturers Cope With the Limits of Circular Product Design

Business Strategy and the Environment, EarlyView.
ABSTRACT Circular product design (CPD) is central to advancing the circular economy by enabling the narrowing, slowing, and closing of resource flows. Yet, its implementation remains persistently challenging for firms. Prior research has largely framed these challenges as discrete barriers, overlooking the structural contradictions embedded in CPD ...
Vanessa Robertson, Nelly Rahimy, Suleika Bort   +2 more
wiley   +1 more source