Results 41 to 50 of about 2,466,460 (289)

Dual-site spatiotemporal and simultaneous inhibition on PIN1 via arsenic-retinoic albumin nanoparticles enables synergistic oncotherapy

Journal of Nanobiotechnology
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is a master regulator of oncogenic signaling, uniquely catalyzing the isomerization of phosphorylated Ser/Thr-Pro motifs to drive malignant transformation, proliferation, and metastasis ...
Dayun Yang, Jianping Wang, Ruoru Liu, Jinfa Chen, Haiying Wen, Yu Li, Bo Lu, Zhao Guo, Daxiang Cui, Lee Jia, Haiyan Dong   +10 more
doaj   +1 more source

Prechemotherapy Levels of Plasma Dehydroepiandrosterone and Its Sulfated Form as Predictors of Cancer-Related Cognitive Impairment in Patients with Breast Cancer Receiving Chemotherapy. [PDF]

, 2019
Study objectiveDehydroepiandrosterone (DHEA) and its sulfated form (DHEAS)-jointly referred to as DHEA(S)-are neurosteroids known to regulate brain development and function that have been found to be positively correlated with cognitive function.
Bansal, Sumit, Chan, Alexandre, Lau, Aik Jiang, Shariq Mujtaba, Juliana, Shwe, Maung, Toh, Yi Long, Yeo, Angie   +6 more
core   +2 more sources

Acute and Chronic Effects of Green Oat (Avena sativa) Extract on Cognitive Function and Mood during a Laboratory Stressor in Healthy Adults: A Randomised, Double-Blind, Placebo-Controlled Study in Healthy Humans [PDF]

, 2020
Green oat (Avena sativa) extracts contain several groups of potentially psychoactive phytochemicals. Previous research has demonstrated improvements in cognitive function following a single dose of these extracts, but not following chronic ...
Bonnländer, Bernd, Forster, Joanne, Jackson, Philippa, Kennedy, David, Khan, Julie, Lang, Stefanie C., Pischel, Ivo, Wightman, Emma   +7 more
core   +2 more sources

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

Altered local intrinsic neural activity and molecular architecture in internet use disorders

Brain Research Bulletin
Background: Internet gaming disorder (IGD) is mainly characterized by its core dysfunction in higher-order brain cortices involved in inhibitory control, whose neurobiological basis remains unclear.
Longyao Ma, Qiuying Tao, Jinghan Dang, Jieping Sun, Xiaoyu Niu, Mengzhe Zhang, Yimeng Kang, Weijian Wang, Jingliang Cheng, Shaoqiang Han, Yong Zhang   +10 more
doaj   +1 more source

Dementia before death in ageing societies--the promise of prevention and the reality.

PLoS Medicine, 2006
BackgroundDementia and severe cognitive impairment are very closely linked to ageing. The longer we live the more likely we are to suffer from these conditions.
Carol Brayne, Lu Gao, Michael Dewey, Fiona E Matthews, Medical Research Council Cognitive Function and Ageing Study Investigators   +4 more
doaj   +1 more source

Cognitive tests used in chronic adult human randomised controlled trial micronutrient and phytochemical intervention studies [PDF]

, 2010
In recent years there has been a rapid growth of interest in exploring the relationship between nutritional therapies and the maintenance of cognitive function in adulthood.
Anderson, Anna L. Macready, Balk, Burgess, Claire M. Williams, Clarke, Detterman, Eussen, Fournier, Ho, Ivers, Jeremy P. E. Spencer, Judi A. Ellis, Knapp, Laurie T. Butler, Lezak, Manly, Maylor, McDaniel, Orla B. Kennedy, Phillips, Rabbitt, Reitan, Rosen, Rugg, Santos, Wechsler, Wechsler, Wesnes   +28 more
core   +1 more source

Psychological Safety Among Interprofessional Pediatric Oncology Teams in Germany: A Nationwide Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn, Anna‐Lena Herbach, Christian Bock, Katharina Fleig, Urs Mücke   +4 more
wiley   +1 more source

ChaC1-based drug screenings identify a synergistic lethal effect of auranofin and proteasome inhibitors in hepatocellular carcinoma cells

Cell Death Discovery
The γ-glutamylcyclotransferase, ChaC1, is an enzyme catalyzing glutathione (GSH) degradation. In this study, we performed a ChaC1-activity-directed pharmacological screening from FDA-approved drug library to identify GSH-sensitive agents, and found that ...
Cheng Yu, Jinyu Liu, Hejia Jian, Biwen Wen, Mingting Jiang, Binghui Zhang, Meiyan Lin, Junjin Lin, Zichan Dai, Chuan-Qi Zhong, Min Zheng   +10 more
doaj   +1 more source

Developmental Disorders in Children Recently Diagnosed With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag, Long Vu, Ritika Miryala, Jeffrey M. Albert, Molly McVoy, Siran M. Koroukian   +5 more
wiley   +1 more source