Results 61 to 70 of about 641,525 (312)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Predictive factors and risk and protection groups for loneliness in older adults: a population-based study

BMC Psychology
Background Loneliness is considered a public health problem, particularly among older adults. Although risk factors for loneliness have been studied extensively, fewer studies have focused on the protected and risk groups that these factors configure ...
Pedro Montejo Carrasco, David Prada Crespo, Ana Isabel Reinoso García, Monserrat Lozano Ibáñez, Borja Montejo Rubio, Mercedes Montenegro-Peña   +5 more
doaj   +1 more source

DelIrium VULnerability in GEriatrics (DIVULGE) study: a protocol for a prospective observational study of electroencephalogram associations with incident postoperative delirium

BMJ Neurology Open, 2021
Introduction Delirium is a neurocognitive disorder common in older adults in acute care settings. Those who develop delirium are at an increased risk of dementia, cognitive decline and death.
Daniel H J Davis, Peter J Psaltis, Alice Bourke, Hannah A D Keage, Monique S Boord, Scott W Coussens, Daniel Feuerriegel, Marta I Garrido   +7 more
doaj   +1 more source

Identifying Cancer-Related Cognitive Impairment Using the FACT-Cog Perceived Cognitive Impairment. [PDF]

, 2020
Cancer-related cognitive impairment (CRCI) is a concerning problem for many cancer survivors. Evaluating patients for CRCI has been a challenge, in part because of a lack of standardized practices.
Crespi, Catherine M, Dyk, Kathleen Van, Ganz, Patricia A, Petersen, Laura   +3 more
core   +1 more source

Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients. [PDF]

, 2018
In December 2017, the National Academy of Neuropsychology convened an interorganizational Summit on Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients in Denver, Colorado. The Summit brought together representatives of a
Adler, Deb, Alban, Christopher, Bondi, Mark, Braun, Michelle, Cagigas, Xavier, Daven, Morgan, Denney, Robert L, Drozdick, Lisa, Foster, Norman L, Golden, Tamara, Hwang, Ula, Iverson, Grant, Ivey, Laurie, Kramer, Joel, Lacritz, Laura, Lantz, Melinda, Latts, Lisa, Ling, Shari M, Malone, Michael, Maria Lopez, Ana, Martin-Plank, Lori, Maslow, Katie, McConnel, Charles E, Melady, Don, Messer, Melissa, Meyers, John, Most, Randi, Norris, Margaret P, Perry, William, Pliskin, Neil, Roebuck-Spencer, Tresa, Shafer, David, Silver, Cheryl, Silverberg, Nina, Thomas, Colin M, Thornhill, Laura, Tsai, Jean, Vakharia, Nirav, Waters, Martin   +38 more
core   +2 more sources

Mechanisms in neurodegenerative disorders and role of non-pharmacological interventions in improving neurodegeneration and its clinical correlates: A review [PDF]

arXiv, 2023
Mild cognitive impairment (MCI) leading to dementia results in a constellation of psychiatric disorders including depression, mood disorders, schizophrenia and others. With increasing age, mild cognitive impairment leads to increased disability-adjusted life-years and healthcare burden.
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Event-Related Potentials in Relation to Risk-Taking: A Systematic Review

Frontiers in Behavioral Neuroscience, 2018
Event-related potentials (ERPs) have been used to investigate neural mechanisms underlying risk-related decisions over the last 16 years. We aimed to systematically evaluate associations between risk-taking and ERP components elicited during decisions ...
Dilushi Chandrakumar, Daniel Feuerriegel, Daniel Feuerriegel, Stefan Bode, Megan Grech, Hannah A. D. Keage   +5 more
doaj   +1 more source

Dissociation of Alzheimer's morphological pathology from cognitive impairment [PDF]

, 2009
We observed the Alzheimer's morphological pathology, amyloid production induces Alzheimer's cognitive impairment, was dissociated from the cognitive impairment.
Nobuyuki Mikoda, Tohru Hasegawa
core   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source