Results 81 to 90 of about 363,866 (292)

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Maturation trajectories of cortical resting-state networks depend on the mediating frequency band [PDF]

, 2018
The functional significance of resting state networks and their abnormal manifestations in psychiatric disorders are firmly established, as is the importance of the cortical rhythms in mediating these networks. Resting state networks are known to undergo
Bekhti, Yousra, Bharadwaj, Hari, Ganesan, Santosh, Garel, Keri-Lee A., Gollub, Randy L., Hamalainen, Matti S., Hashmi, Javeria A., Kenet, Tal, Khan, Sheraz, Kitzbichler, Manfred G., Kong, Jian, Mamashli, Fahimeh, Michmizos, Konstantinos, Rana, Kunjan D., Stufflebeam, Steven M., Vaina, Lucia M., Whitfield-Gabrieli, Susan   +16 more
core   +1 more source

Relative Trajectories of Gait and Cognitive Decline in Aging

The Journals of Gerontology: Series A, 2021
Abstract Background Gait and cognition decline with advancing age, and presage the onset of dementia. Yet, the relative trajectories of gait and cognitive decline in aging are poorly understood—particularly among those with the motoric cognitive risk (MCR) syndrome.
Oshadi Jayakody, Monique Breslin, Emmeline Ayers, Joe Verghese, Nir Barzilai, Sofiya Milman, Erica Weiss, Helena M Blumen   +7 more
openaire   +2 more sources

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Analysis of cognitive function trajectories and influencing factors in elderly patients with ischemic stroke: a prospective longitudinal study

Frontiers in Aging Neuroscience
Background and purposeAccurately defining cognitive function trajectories in elderly ischemic stroke patients is crucial for identifying high-risk groups for cognitive decline, enabling timely personalized interventions to improve long-term outcomes and ...
Xinhao Chen, Chengxia Wei, Danli Zhao, Chenmei Zhou, Wenjing Wang, Gendi Lu, Gendi Lu   +6 more
doaj   +1 more source

Coordinated analysis of age, sex, and education effects on change in MMSE scores [PDF]

, 2012
Objectives. We describe and compare the expected performance trajectories of older adults on the Mini-Mental Status Examination (MMSE) across six independent studies from four countries in the context of a collaborative network of longitudinal studies of
A. M. Piccinin, A. Mackinnon, A. Spiro, Aevarsson, Alley, Anstey, B. Johansson, Butler, C. A. Reynolds, Christensen, Christensen, Colsher, Colsher, Crane, D. J. H. Deeg, DerSimonian, Enders, Evans, Farmer, Folstein, G. Muniz-Terrera, GEERLINGS, Gibbons, Glymour, Glymour, Hofer, Huisman, I. J. Deary, I. Skoog, J. M. Starr, Jacqmin-Gadda, Lyketsos, Manly, Pedersen, Pfeiffer, Rinder, S. Clouston, S. M. Hofer, Skoog, Stern, Svanborg, Terrera, Tucker-Drob, V. Thorvaldsson, Van Dijk, Wainer, Zahodne   +46 more
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Dual group-based trajectories of physical activity and cognitive function in aged over 55: a nationally representative cohort study

Frontiers in Public Health
BackgroundAs individuals age, they commonly experience reduced physical activity and cognitive decline. While evidence, there is limited trajectory research on their concurrent progression and interrelation in individuals over 55 years old.MethodsThe ...
Xiaotong Wang, Pei Hu, Yating Ai, Shi Zhou, Yucan Li, Pengjun Zhou, Gao Chen, Yuncui Wang, Hui Hu, Hui Hu, Hui Hu   +10 more
doaj   +1 more source

Modeling user navigation [PDF]

, 2003
This paper proposes the use of neural networks as a tool for studying navigation within virtual worlds. Results indicate that the network learned to predict the next step for a given trajectory.
Mangina, E., Marian, I., O'Hare, G.M.P., Reilly, R., Sas, Corina   +4 more
core