Results 61 to 70 of about 2,345,325 (297)

Amyloid‐negative neuropsychological norms: Added value in the era of biomarkers and disease‐modifying therapies

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION We previously applied generalized additive models for location, scale, and shape to derive amyloid β–negative next‐generation norms (NGN) for a comprehensive neuropsychological battery.
Sara Rubio‐Guerra, Isabel Sala, María Belén Sánchez‐Saudinós, Laura Videla, Alexandre Bejanin, Ainara Estanga, Mirian Ecay‐Torres, Carolina Lopez deLuis, Lorena Rami, Adrià Tort‐Merino, Magdalena Castellví, Ana Pozueta, María García‐Martínez, David Gómez‐Andrés, Carmen Lage, Sara López‐García, Pascual Sánchez‐Juan, Mircea Balasa, Albert Lladó, Miren Altuna, Mikel Tainta, Javier Arranz, Nuole Zhu, Daniel Alcolea, Alberto Lleó, Juan Fortea, Eloy Rodríguez Rodríguez, Raquel Sánchez‐Valle, Pablo Martínez‐Lage, Ignacio Illán‐Gala   +29 more
doaj   +1 more source

Internal consistency over time of subjective cognitive decline: Drawing preclinical Alzheimer's disease trajectories

, 2018
Artículo aceptado para publicación: Ávila-Villanueva M, Maestú F, Fernández-Blázquez MA. Internal Consistency Over Time of Subjective Cognitive Decline: Drawing Preclinical Alzheimer’s Disease Trajectories. Journal of Alzheimer’s Disease.
Maestu Unturbe, Fernando, Ávila Villanueva, Marina, Fernández Blázquez, Miguel Ángel   +2 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Cohort Effects in Age-Associated Cognitive Trajectories [PDF]

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2013
The age-specific prevalence and incidence of dementia and cognitive impairment in the United States have either remained stable or even slightly declined during the 1980s-1990s. A suggested but untested reason for this improvement in cognitive function over time is higher educational attainment among more recent cohorts.We used data from two large ...
Hiroko H, Dodge, Jian, Zhu, Ching-Wen, Lee, Chung-Chou Ho, Chang, Mary, Ganguli   +4 more
openaire   +2 more sources

Cognitive trajectories and their relationships with education and diets among older adults: a network-based 10-year cohort study

Frontiers in Aging Neuroscience
ObjectivesFew studies have examined the underlying mechanisms of education, diets, and cognitive function in older adults. This study analyses the relationship between cognitive trajectories, education, and different dietary patterns in older adults from
Xuchun Wang, Yuchao Qiao, Yudong Zhang, Yu Cui, Hao Ren, Chongqi Hao, Lixia Qiu   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Exploiting Vestibular Output during Learning Results in Naturally Curved Reaching Trajectories [PDF]

, 2005
Teaching a humanoid robot to reach for a visual target is a complex problem in part because of the high dimensionality of the control space. In this paper, we demonstrate a biologically plausible simplification of the reaching process that replaces the ...
Sun, Ganghua, Scassellati, Brian
core  

Worry and cognitive control predict course trajectories of anxiety in older adults with late-life depression [PDF]

, 2017
Background: Many older adults with depressive disorder manifest anxious distress. This longitudinal study examines the predictive value of worry as a maladaptive cognitive emotion regulation strategy, and resources necessary for successful emotion ...
Van der Veen, D.C., D.C. van der Veen, H.C. Comijs, Spinhoven, P., Voshaar, R.C.O., Voshaar, R C Oude, Voshaar, R C Oude; id_orcid, van der Veen, D. C., Comijs, H.C., Voshaar, R. C.Oude, van der Veen, D C, Comijs, H C, Veen, D.C. van der, P. Spinhoven, Spinhoven, P, R.C. Oude Voshaar   +15 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Trajectories

, 2018
Contains folders for each of the proteins tested with trajectories from both native and denovo initial structures. The trajectories are of the lowest temperature replicas, which were the ones used in the bulk of the analysis.
John M. Jumper (1301859), Jumper, John M., Sosnick, Tobin R., Faruk, Nabil F., Freed, Karl F., Karl F. Freed (181039), Tobin R. Sosnick (181042), Nabil F. Faruk (6160142)   +7 more
core   +1 more source