Effects of post‐ovulatory aging on centromeric cohesin protection in murine MII oocytes [PDF]
Reproductive Medicine and Biology, 2022 Purpose Post‐ovulatory aging causes a high frequency of aneuploidy during meiosis II in mouse oocytes, irrespective of maternal age. In this study, we evaluated the effects of post‐ovulatory oocyte aging on the protection of chromosomal cohesion involved
Gaku Shimoi +3 more
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Eliminating separase inhibition reveals absence of robust cohesin protection in oocyte metaphase II [PDF]
The EMBO JournalThe meiotic segregation pattern to generate haploid gametes is mediated by step-wise cohesion removal by separase, first from chromosome arms in meiosis I, and then from the pericentromere in meiosis II.
Safia El Jailani +7 more
doaj +2 more sources
Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I [PDF]
Nature Communications, 2017 In meiosis I centromeric cohesin is protected by Sgo2 from Separase-mediated cleavage ensuring that sister chromatids are kept together until their separation in meiosis II.
Warif El Yakoubi +9 more
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Crosstalk between cohesins and axis proteins determines meiotic chromosome architecture in Sordaria macrospora. [PDF]
PLoS GeneticsFaithful chromosome segregation during meiosis requires the coordinated action of cohesin complexes and chromosome axis proteins. How these factors interact and communicate along chromosome axes, especially during meiotic prophase I, remains however ...
Kenza Yefsah +6 more
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A chromatin-remodeling-independent role for ATRX in protecting centromeric cohesion [PDF]
The EMBO JournalSister-chromatid cohesion mediated by the cohesin complex is critical for accurate chromosome segregation during mitosis. A key aspect of this process is the protection of cohesin at mitotic centromeres to resist spindle pulling-forces until anaphase ...
Lei Zhao +4 more
doaj +2 more sources
Meiosis-specific distal cohesion site decoupled from the kinetochore [PDF]
Nature CommunicationsPrimary constriction of the M-phase chromosome serves as a marker for the kinetochore position. Underlying this observation is the concept that the kinetochore is spatially linked with the pericentromere where sister-chromatids are cohered. Here, we find
Bo Pan +3 more
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Separase Control and Cohesin Cleavage in Oocytes: Should I Stay or Should I Go?
Cells, 2022 The key to gametogenesis is the proper execution of a specialized form of cell division named meiosis. Prior to the meiotic divisions, the recombination of maternal and paternal chromosomes creates new genetic combinations necessary for fitness and ...
Katja Wassmann
doaj +1 more source
Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion. [PDF]
PLoS Genetics, 2018 Establishment of sister chromatid cohesion is coupled to DNA replication, but the underlying molecular mechanisms are incompletely understood. DDX11 (also named ChlR1) is a super-family 2 Fe-S cluster-containing DNA helicase implicated in Warsaw breakage
Giuseppe Cortone +8 more
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Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development
Frontiers in Immunology, 2022 Plasma cells (PCs) and their progenitors plasmablasts (PBs) are essential for the acute and long-term protection of the host against infections by providing vast levels of highly specific antibodies.
Theresa Pinter +7 more
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A PP2A-B56—Centered View on Metaphase-to-Anaphase Transition in Mouse Oocyte Meiosis I
Cells, 2020 Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes—oocytes and sperm—with the correct number of chromosomes.
Leonor Keating +2 more
doaj +1 more source