Results 11 to 20 of about 2,119,312 (119)
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML [PDF]
, 2021 The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer including myelodysplatic syndromes (MDS) and acute myeloid ...Catherine C. Landers, Dekker, J., Edwin Chen, Tothova, Z., Kasper Lage, Steven A. Carr, Benjamin L. Ebert, Valton, A., Holmes, A., Carr, S.A., Sebastian Koochaki, Landers, C.C., Mounica Vallurupalli, Christina Hartigan, Haydu, J.E., Edyta Malolepsza, Popova, K.D., Lage, K., Zuzana Tothova, Schenone, M., Chen, E., Alan D. D’Andrea, Elizabeth A. Morgan, Melanie Donahue, Ebert, B.L., Venev, S.V., Krill-Burger, J.M., Anne-Laure Valton, Katerina D. Popova, Hartigan, C.R., Monica Schenone, Morgan, E.A., J. Erika Haydu, Jeanne Rivera, Malolepsza, E., Donahue, M., Sergey V. Venev, Rebecca A. Gorelov, D'Andrea, A.D., John M. Krill-Burger, Koochaki, S.H.J., Gorelov, R., Amie Holmes, Job Dekker, Rivera, J.F., Vallurupalli, M. +45 morecore +1 more sourceThe cohesin ring concatenates sister DNA molecules [PDF]
, 2008 Sister chromatid cohesion, which is essential for mitosis, is mediated by a multi-subunit
protein complex called cohesin whose Scc1, Smc1, and Smc3 subunits form a tripartite
ring structure.Arumugam, P, Nasmyth, Kim, Haering, Christian H., Haering, CH, Metson, Jean, Metson, J, Arumugam, Prakash, Nasmyth, K, Farcas, Ana-Maria, Farcas, AM +9 morecore +1 more sourceGenetic heterogeneity in Cornelia de Lange syndrome (CdLS) and CdLS-like phenotypes with observed and predicted levels of mosaicism [PDF]
, 2014 Cornelia de Lange syndrome (CdLS) is a multisystem disorder with distinctive facial appearance, intellectual disability and growth failure as prominent features.Aldridge, Roland, Green, Andrew J, Lampe, A., McKee, Shane A., Kingston, Helen, Kayserili, H., Bitner-Glindzicz, M, Chan, Cheng Yee, Kayserili, Hülya, Cooper, Nicola S, Mansour, S, Chandler, K, Ross, Alison, Bitner-Glindzicz, Maria, Ansari, M., Aldridge, R., Bennett, CP, Donnelly, D. E., Davidson, R, Chan, C. Y., Girisha, KM, Poke, G., Cook, J., Lampe, Anne K., Pilz, Daniela T, Chan, C., Poke, Gemma, Park, Soo-Mi, Ferry, Q., Lam, Wayne K, Cook, JA, Splitt, M., Johnson, Diana S., Wee, Jamie S., Deshpande, C, Falkenberg Smeland, Marie, Chan, CY, Avci, Şahin, Hurst, Jane A, Lam, W. K., Deshpande, C., Meynert, A., Bennett, C. P., Green, A. J., Donnai, D., Bengani, Hemant, Pilz, D. T., McEntagart, M, Thompson, Elizabeth M., Mansour, Sahar, Deshpande, Charu, McConnell, Vivienne, Davidson, Rosemarie, FitzPatrick, D. R., McEntagart, Meriel, Cooper, Nicola S., Thompson, E. M., Josifova, D., Holder, S. E., Green, Andrew J., Taylor, M. S., Homfray, Tessa, Kingston, H, FitzPatrick, DR, Tatton-Brown, Katrina, Hurst, J. A., Taylor, MS, Barnicoat, Angela, Magee, A. C., Parker, M. J., Wilson, L, Clayton-Smith, Jill, Flinter, F., Tolmie, J., Wee, J. S., Donnelly, Deirdre E., Lampe, Anne K, Fisher, Richard B, Green, AJ, Redeker, Egbert, Mehta, Sarju G, Hennekam, R. C. M., Prescott, K., Sisodiya, S., Mohammed, S., Wilson, Louise, Cox, H., Johnson, D. S., Mercer, C, Mohammed, S, Hennekam, RCM, Tatton-Brown, K, Redeker, E, Tolmie, John, Parker, Michael J., Meynert, Alison M, McEntagart, M., Vogt, Julie, Vogt, J, Chandler, K., Williamson, K., Fisher, R. B., Parker, M., et al., Magee, Alex C., Cox, H, Taylor, Martin S., Fryer, A, McKee, S. A., Ansari, M, Fryer, Alan, Firth, Helen V, Donnai, Dian, Firth, H. V., Hurst, JA, Lynch, Sally-Ann, Park, S-M, Brady, A. F., Behnam, Mahdiyeh, Cooper, N. S., Parker, MJ, Pilz, Daniela T., Harrison, V, Parker, Michael J, Wakeling, Emma, Behnam, M, Cooper, NS, Lampe, AK, Johnson, Diana S, Clayton-Smith, J., McKee, SA, McConnell, V, Homfray, T, Tolmie, J, McConnell, V., Lam, Wayne K., Barnicoat, A., Davidson, R., Firth, HV, Bennett, Christopher P, Ross, A, Donnelly, Deirdre E, Pilz, DT, Cilliers, D., Hennekam, Raoul C M, Taylor, Martin S; id_orcid, Falkenberg Smeland, M, Harrison, V., Holder, Susan E., Mercer, C., Brady, Angela F., Thompson, EM, Josifova, D, Stewart, Fiona, Harrison, Victoria, Lynch, SA, Smeland, Marie Falkenberg, Mehta, Sarju G., Wilkie, A, Wakeling, E., Firth, Helen V., Cilliers, Deirdre, Flinter, F, Girisha, Katta M., Splitt, Miranda, Meynert, A. M., Mehta, SG, Lam, WK, Homfray, T., Kayserili, H, Wee, Jamie S, Mohammed, Shehla, Cox, Helen, Bengani, H, Brady, Angela F, Donnelly, DE, Hennekam, RC, Barnicoat, A, Sisodiya, Sanjay, Ferry, Q, Kinning, Esther, Kinning, E., Fisher, Richard B., Wee, JS, Smeland, MF, Meynert, Alison M., Magee, Alex C, Brady, AF, Nellaker, C., Bitner-Glindzicz, M., Mansour, S., Holder, SE, Prescott, Katrina, Lynch, S-A, Cook, Jacqueline A, Williamson, Kathleen, Ruddy, D, Avci, S, Johnson, DS, Falkenberg Smeland, M., Stewart, F, Clayton-Smith, J, Lampe, A. K., Nellåker, C, Fryer, A., Smeland, M., Redeker, E., Girisha, K. M., Hurst, Jane A., Chandler, Kate, Avci, ahin, Nellåker, Christoffer, Lynch, S.-A., Ansari, Morad, FitzPatrick, David R, Wilson, L., Hennekam, Raoul C. M., Fitzpatrick, David R., Poke, G, Cilliers, D, Rosser, E., Ruddy, Deborah, Park, S.-M., Donnai, D, Wilkie, Andrew, Holden, Simon, Meynert, AM, Tatton-Brown, K., McKee, Shane A, Hennekam, R., Vogt, J., Magee, AC, Holder, Susan E, Ruddy, D., Aldridge, R, Williamson, K, Flinter, Frances, Mehta, S. G., Fisher, RB, Kinning, E, Park, SM, Prescott, K, Splitt, M, Josifova, Dragana, Girisha, Katta M, Holden, S., Rosser, E, Wakeling, E, Wilkie, A., Mercer, Catherine, Bengani, H., Ross, A., Kingston, H., Avci, Ş., Thompson, Elizabeth M, Rosser, Elisabeth, Cook, Jacqueline A., Ferry, Quentin, Sisodiya, S, Stewart, F., Behnam, M., Holden, S, Cook, J. A., Bennett, Christopher P. +263 morecore +1 more sourceSmc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]
, 2013 During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.Philip W. Jordan (265255), Copsey A., Prakash Arumugam, Sonya Newcombe (502072), Jordan, Philip W., Gray S., Alice Copsey (4460686), Alex D Herbert, Eva Hoffmann (159398), Li, Zhaobo, Shangming Tang, Zhaobo Li, Stephen Gray, Newnham, Louise, Herbert A.D., Chan, Andrew Chi-ho, Hannah G. Blitzblau (159462), Blitzblau, Hannah G., Gray, Stephen, Alex Herbert (725932), Hannah G Blitzblau, Hannah Blitzblau (5185454), Newcombe S., Tang, Shangming, Stephen Gray (3278418), Newnham L., Li Z., Hunter, Neil, Andrew Chi-ho Chan (3278421), Hochwagen, Andreas, Arumugam, Prakash, Shangming Tang (502071), Hochwagen A., Alice Copsey, Alice Copsey (502070), Copsey, Alice, Herbert, Alex D., Hoffmann E., Blitzblau H.G., Andreas Hochwagen (159466), Arumugam P., Louise Newnham, Neil Hunter, Philip W Jordan (16188074), Jordan P.W., Alex D. Herbert (502074), Philip W Jordan, Andrew Chi-Ho Chan, Louise Newnham (430862), Sonya Newcombe, Chan, Andrew Chi ho, Tang S., Prakash Arumugam (303310), Eva Hoffmann, Newcombe, Sonya, Andreas Hochwagen, Hunter N., Chan A.C.-h., Neil Hunter (155061), Steve Gray (5950955), Zhaobo Li (502073), Hoffmann, Eva +61 morecore +1 more sourceThe chromosomal association of the Smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement.
PLoS Genetics, 2014 The cohesin complex, which is essential for sister chromatid cohesion and chromosome segregation, also inhibits resolution of sister chromatid intertwinings (SCIs) by the topoisomerase Top2. The cohesin-related Smc5/6 complex (Smc5/6) instead accumulates Kristian Jeppsson, Kristian K Carlborg, Ryuichiro Nakato, Davide G Berta, Ingrid Lilienthal, Takaharu Kanno, Arne Lindqvist, Maartje C Brink, Nico P Dantuma, Yuki Katou, Katsuhiko Shirahige, Camilla Sjögren +11 moredoaj +1 more source
