Results 21 to 30 of about 2,119,312 (119)
Cohesin architecture and clustering in vivo [PDF]
, 2021 Cohesin helps mediate sister chromatid cohesion, chromosome condensation, DNA repair, and transcription regulation. We exploited proximity-dependent labeling to define the in vivo interactions of cohesin domains with DNA or with other cohesin domains ...
Douglas Koshland +3 more
core +1 more source
mBio, 2015 Ruminococcus bromii is a dominant member of the human gut microbiota that plays a key role in releasing energy from dietary starches that escape digestion by host enzymes via its exceptional activity against particulate “resistant” starches.
Xiaolei Ze +11 more
doaj +1 more source
Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]
, 2015 SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...
Soh, Young-Min +69 more
core +1 more source
Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2. [PDF]
, 2023 Cohesin organizes the genome through the formation of chromatin loops. NIPBL activates cohesin's ATPase and is essential for loop extrusion, but its requirement for cohesin loading is unclear.
Alonso-Gil, Dácil +4 more
core +1 more source
Nuclear Import and Export Signals of Human Cohesins SA1/STAG1 and SA2/STAG2 Expressed in Saccharomyces cerevisiae [PDF]
, 2012 Background: Human SA/STAG proteins, homologues of the yeast Irr1/Scc3 cohesin, are the least studied constituents of the sister chromatid cohesion complex crucial for proper chromosome segregation.
Jurek, Marta +27 more
core +1 more source
PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection. [PDF]
, 2020 Cohesin is a chromatin-bound complex that mediates sister chromatid cohesion and facilitates long-range interactions through DNA looping. How the transcription and replication machineries deal with the presence of cohesin on chromatin remains unclear ...
Rodríguez-Acebes, Sara +11 more
core +1 more source
eLife, 2012 During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain together.
Matthew P Miller +3 more
doaj +1 more source
Phosphorylation of Rec8 cohesin complexes regulates mono-orientation of kinetochores in meiosis I
Life Science AlliancePhosphorylation of the Rec8 cohesin complexes plays a crucial role in establishing mono-orientation of sister kinetochores which is important for reductional division in meiosis I in fission yeast. In meiosis I, unlike in mitosis, sister kinetochores are
Yu Liu +3 more
doaj +1 more source
Roles of meiotic and mitotic cohesin in stem cell gene regulation and genome stability
Molecular Therapy: Nucleic AcidsCohesin, a ring-shaped SMC complex, mediates sister-chromatid cohesion, DNA repair, and genome folding via loop extrusion. Pluripotent and somatic cells were thought to rely solely on mitotic cohesin (SMC1A, SMC3, RAD21, STAG1/STAG2), while meiosis ...
Soo Min Cho +2 more
doaj +1 more source
VEZF1 elements mediate protection from DNA methylation [PDF]
, 2010 There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
Gowher Humaira +21 more
core +2 more sources