Results 31 to 40 of about 2,119,312 (119)
Advanced Science, EarlyView.Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao +11 more
wiley +1 more source
Advanced Science, EarlyView.Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang +12 more
wiley +1 more source
Genomic analysis of cohesin dynamics in fission yeast [PDF]
, 2009 Cohesin holds sister chromatids together and facilitates their accurate segregation in mitosis. Little is known about how and where cohesin binds to chromosomes.
Schmidt, C.K., Schmidt, C K
core
Advanced Science, EarlyView.To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai +4 more
wiley +1 more source
Irr1/Scc3 Cohesin Interacts with Rec8 in Meiotic Prophase of Saccharomyces cerevisiae [PDF]
, 2011 The meiotic cohesin complex of S. cerevisiae shares with the mitotic one the Irr1/Scc3, Smc1, and Smc3 subunits, while the meiosis-specific subunit Rec8 re-places mitotic subunit Scc1/Mcd1.
Cena, Agata +7 more
core
Advanced Science, EarlyView.Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo +11 more
wiley +1 more source
Advanced Science, Volume 13, Issue 49, 3 September 2026.Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg +18 more
wiley +1 more source
Enhancing the resolution of cohesin dynamics in meiosis [PDF]
, 2018 Meiosis is a specialized form of cell division in which one diploid mother cell is converted into four haploid daughter cells. Cohesin is a multi-protein complex, providing cohesion to replicated chromosomes.
Graf, Peter
core +2 more sources
Advanced Science, Volume 13, Issue 52, 18 September 2026.eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu +12 more
wiley +1 more source
Journal of Applied Toxicology, Volume 46, Issue 9, Page 2985-2996, September 2026.ABSTRACT Parabens (PBs) are compounds widely used as preservatives in personal care products, food, and pharmaceuticals. Methylparaben (MePB) is the most used by different industries due to its chemical properties and low cost. The high daily human exposure to these compounds has raised concerns about their potential effects on health, particularly on ...
Yenny Ramírez‐Jara +11 more
wiley +1 more source