Results 81 to 90 of about 3,623 (177)

Adaptor Scaffoldins: An Original Strategy for Extended Designer Cellulosomes, Inspired from Nature

mBio, 2016
Designer cellulosomes consist of chimeric cohesin-bearing scaffoldins for the controlled incorporation of recombinant dockerin-containing enzymes. The largest designer cellulosome reported to date is a chimeric scaffoldin that contains 6 cohesins.
Johanna Stern, Sarah Moraïs, Raphael Lamed, Edward A. Bayer   +3 more
doaj   +1 more source

Inflammatory signatures in the spectrum of myeloid diseases

HemaSphere, Volume 10, Issue 7, July 2026.
Abstract Dysregulated innate immunity contributes to clonal cytopenias and myeloid neoplasms, but its extent across disease stages and clinical relevance remain incompletely defined. We analyzed plasma ASC/NLRP3 double‐positive (DP) specks, ASC single‐positive (SP) specks, and 45 cytokines in 223 patients with idiopathic cytopenias of undetermined ...
Alice Ibbotson, Simon Crouch, Jacqueline Ferrari, Thomas Young, Ann W. Morgan, Anna Gallì, Sara Pozzi, Martina Sarchi, Virginia Camilotto, Martina Boldini, Chiara Elena, Luca Malcovati, Sinisa Savic   +12 more
wiley   +1 more source

Interallelic complementation provides functional evidence for cohesin–cohesin interactions on DNA

Molecular Biology of the Cell, 2015
The cohesin complex (Mcd1p, Smc1p, Smc3p, and Scc3p) has multiple roles in chromosome architecture, such as promoting sister chromatid cohesion, chromosome condensation, DNA repair, and transcriptional regulation. The prevailing embrace model for sister chromatid cohesion posits that a single cohesin complex entraps both sister chromatids.
Eng, Thomas, Guacci, Vincent, Koshland, Douglas   +2 more
openaire   +4 more sources

Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice

Biology Open, 2018
Lanosterol 14 α-demethylase (CYP51) plays a crucial role in cholesterol biosynthesis. In gamete development, CYP51 is involved in initiating meiosis resumption in oocytes through its product, meiosis activating sterol (MAS).
Xinyi Mu, Jia Wen, Qian Chen, Zhengpin Wang, Yijing Wang, Meng Guo, Yi Yang, JinRui Xu, Zhiqing Wei, Guoliang Xia, Mengye Yang, Chao Wang   +11 more
doaj   +1 more source

Taking cohesin and condensin in context

PLOS Genetics, 2018
Structural maintenance of chromosome (SMC) protein complexes, including cohesin and condensin, are increasingly being recognized for their important role in cancer and development, making it critical that we understand how these evolutionarily conserved multi-subunit protein complexes associate with and organize the genome.
Kobe C. Yuen, Jennifer L. Gerton
openaire   +3 more sources

Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.

PLoS Genetics, 2015
Proper meiotic chromosome segregation, essential for sexual reproduction, requires timely formation and removal of sister chromatid cohesion and crossing-over between homologs. Early in meiosis cohesins hold sisters together and also promote formation of
Naina Phadnis, Lubos Cipak, Silvia Polakova, Randy W Hyppa, Ingrid Cipakova, Dorothea Anrather, Lucia Karvaiova, Karl Mechtler, Gerald R Smith, Juraj Gregan   +9 more
doaj   +1 more source

A new meiosis‐specific cohesin complex implicated in the cohesin code for homologous pairing

The EMBO Reports, 2011
We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21.
Ishiguro, Kei-ichiro, Kim, Jihye, Fujiyama-Nakamura, Sally, Kato, Shigeaki, Watanabe, Yoshinori   +4 more
openaire   +2 more sources

Engineering the cell surface display of cohesins for assembly of cellulosome-inspired enzyme complexes on Lactococcus lactis

Microbial Cell Factories, 2010
Background The assembly and spatial organization of enzymes in naturally occurring multi-protein complexes is of paramount importance for the efficient degradation of complex polymers and biosynthesis of valuable products.
Wieczorek Andrew S, Martin Vincent JJ
doaj   +1 more source

Orderly mitosis shapes interphase genome architecture

eLife
Genomes assume a complex 3D architecture in the interphase cell nucleus. Yet the molecular mechanisms that determine global genome architecture are only poorly understood.
Krishnendu Guin, Adib Keikhosravi, Raj Chari, Gianluca Pegoraro, Tom Misteli   +4 more
doaj   +1 more source

Regulation of pericentromeric DNA loop size via Scc2-cohesin interaction

iScience
Summary: Cohesin exhibits DNA loop extrusion when bound to the ATPase activator Scc2 (NIPBL in humans), which has been proposed to organize higher-order chromosome folding. In budding yeast, most chromosome-bound cohesins lack Scc2.
Sao Anh Nguyen, Toyonori Sakata, Katsuhiko Shirahige, Takashi Sutani   +3 more
doaj   +1 more source