Results 71 to 80 of about 35,198 (261)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Coincidence Points of Weaker Contractions in Partially Ordered Metric Spaces

Journal of Applied Mathematics, 2013
We prove new coincidence point theorems for the -contractions and generalized Meir-Keeler-type --contractions in partially ordered metric spaces. Our results generalize many recent coincidence point theorems in the literature.
Kuo-Ching Jen, Ing-Jer Lin, Chi-Ming Chen   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Coupled Coincidence Points of Mappings in Ordered Partial Metric Spaces

Abstract and Applied Analysis, 2012
New coupled coincidence point and coupled fixed point results in ordered partial metric spaces under the contractive conditions of Geraghty, Rakotch, and Branciari types are obtained. Examples show that these results are distinct from the known ones.
Zorana Golubović, Zoran Kadelburg, Stojan Radenović   +2 more
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

On coincidence and common fixed points of nearly densifying mappings

International Journal of Mathematics and Mathematical Sciences, 2000
Coincidence and common fixed point theorems for certain new classes of nearly densifying mappings are established. Our results extend, improve, and unify a lot of previously known theorems.
Zeqing Liu, Jeong Sheok Ume
doaj   +1 more source

Positive coincidence points for a class of nonlinear operators and their applications to matrix equations

Open Mathematics, 2020
Consider an ordered Banach space and f,gf,g two self-operators defined on the interior of its positive cone. In this article, we prove that the equation f(X)=g(X)f(X)=g(X) has a positive solution, whenever f is strictly α\alpha -concave g-monotone or ...
Kedim Imed, Berzig Maher, Ajmi Ahdi Noomen   +2 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The Study of Fixed Point Theory for Various Multivalued Non-Self-Maps

Abstract and Applied Analysis, 2013
The basic motivation of this paper is to extend, generalize, and improve several fundamental results on the existence (and uniqueness) of coincidence points and fixed points for well-known maps in the literature such as Kannan type, Chatterjea type ...
Wei-Shih Du, Erdal Karapınar, Naseer Shahzad   +2 more
doaj   +1 more source