Results 1 to 10 of about 21,356 (260)
Plasma COL3A1 propeptide as a promising prognostic marker in oral squamous cell carcinoma [PDF]
Scientific ReportsIn this study, we aimed to evaluate the prognostic significance of collagens in patients with oral squamous cell carcinoma (OSCC). Plasma proteomics data from 40 OSCC patients and 33 healthy controls, generated using the Olink Explore 3072 platform ...
Mustafa Magan +3 more
doaj +3 more sources
Cancer Biology and TherapyNon-small cell lung cancer (NSCLC) is among the most difficult malignancies to treat. Type III collagen (COL3A1) can affect the progression and chemoresistance development of NSCLC.
Junyu Lai
exaly +4 more sources
Cancer Medicine, 2023 We aimed to identify a novel prognostic biomarker for head and neck squamous cell carcinoma (HNSCC) based on tumor immunology‐related alternative splicing (AS).
Xitao Yang, Yuchen Shen, Deming Wang
exaly +2 more sources
Integrative Transcriptomic Analysis Identifies COL3A1 as a Potential Tumor-Intrinsic Therapeutic Target in NSCLC [PDF]
BiomedicinesBackground: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, and although PD-1/PD-L1 immune checkpoint blockade has improved outcomes in some patients, therapeutic responses remain heterogeneous.
Kaicheng Zhou +8 more
doaj +2 more sources
Transgenic Tobacco as a Bioreactor for the Production of Bioactive and Triple-Helical Recombinant Type III Collagen [PDF]
PlantsCollagen is the primary protein in the extracellular matrix of human cells and the body and is essential for cell structure and function. Here, for the first time, we report a method for producing recombinant triple-helical collagen type III (rhCOL3) in ...
Tairu Wu +6 more
doaj +2 more sources
Generation of induced pluripotent stem cell (JHUi009-A) and isogenic control (JHUi009-A-1) lines from a patient with vascular Ehlers-Danlos syndrome (vEDS) harboring a pathogenic c.2456G > A in COL3A1 [PDF]
Stem Cell ResearchWe generated and validated a vascular Ehlers-Danlos syndrome (vEDS) human iPSC line, JHUi009-A, carrying a pathogenic COL3A1 c.2456G > A variant, and a CRISPR/Cas9-edited isogenic control line, JHUi009-A-1.
Stanley Chun Ming Wu +3 more
doaj +2 more sources
Identification of Key Targets of Herbal Compounds for Liver Fibrosis Using Network Pharmacology Combined With Transcriptomics [PDF]
Gastroenterology Research and PracticeChinese herbal compound prescriptions have demonstrated efficacy in preventing and treating liver fibrosis (LF), though their mechanisms remained unclear.
Chen Chen +5 more
doaj +2 more sources
Frontiers in MedicineIntroductionTo date, approximately 600 unique pathogenic variants have been reported in COL3A1 associated with vascular Ehlers–Danlos syndrome (vEDS). The objective of this study was to describe a patient with a novel variant in COL3A1 associated with ...
Valeria Valencia Cifuentes +2 more
exaly +3 more sources
Turkish Journal of Kinesiology, 2023 This study was conducted to investigate the genotype and allele distributions of COL3A1 (rs1800255) and COL5A1 (rs12722) polymorphisms of professional footballers who have suffered at least 2 anterior cruciate ligament (ACL) injuries non-contact and ...
Necdet Apaydın +5 more
doaj +1 more source
All Life, 2022 Long non-coding RNAs (lncRNAs) are actively involved in various carcinomas. The purpose of this experiment is to explore the function of long intergenic non-protein coding RNA 01106 (LINC01106) in non-small cell lung cancer (NSCLC).
ZuXiong Zhang +8 more
doaj +1 more source