Results 101 to 110 of about 45,519 (269)

Colchicine-Induced Hepatotoxicity

ACG Case Reports Journal, 2017
Drug-induced injury (DILI) is a frequent cause of abnormal liver tests and a leading cause of liver failure in the United States. Colchicine has long been used as a systemic anti-inflammatory agent for treatment of gout by inhibiting mitotic activity and neutrophil function.
Collette E. Abbott, Samuel H. Sigal, Ruliang Xu   +2 more
openaire   +3 more sources

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Inhibition of free fatty acid mobilization by colchicine

Journal of Lipid Research, 1974
Segments of epididymal adipose tissue from normal male rats were incubated with micromolar concentrations of colchicine for different periods of time up to 4 hr, and the mobilization of free fatty acids (FFA) was measured during a subsequent reincubation.
Richard J. Schimmel
doaj   +1 more source

Fatal colchicine intoxication

Saudi Journal of Anaesthesia, 2014
Colchicine is an alkaloid extracted from autumnal Colchicum plant which is used primarily for its anti-inflammatory therapy effect. Acute intoxication with colchicine is uncommon but often severe and results in multiple visceral organ dysfunctions. The intoxication severity and mortality are directly depending on the ingested dose.
Saïd Boujraf, Adnan Berdai, Smael Labib, Mustapha Harandou   +3 more
openaire   +4 more sources

Colchicine Alleviates Cholesterol Crystal-Induced Endothelial Cell Pyroptosis through Activating AMPK/SIRT1 Pathway

Oxidative Medicine and Cellular Longevity, 2020
Cholesterol crystal- (CC-) induced endothelial cell inflammation and pyroptosis play an important role in the development of cardiovascular diseases, especially in atherosclerosis (AS).
Mengyue Yang, Hang Lv, Qi Liu, Lu Zhang, Ruoxi Zhang, Xingtao Huang, Xuedong Wang, Baihe Han, Shenglong Hou, Dandan Liu, Gang Wang, J. Hou, Bo Yu   +12 more
semanticscholar   +1 more source

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source

Hypersensitivity to Colchicine [PDF]

Annals of the Rheumatic Diseases, 1947
L. Phillips, J. G. Macleod
openaire   +4 more sources

Cutaneous Granulomas Associated With Rubella Replication in TAP Deficiency Syndrome: A Fatal Case Report Evolving Into Cutaneous Squamous Cell Carcinoma and EBV‐Associated Lymphoproliferative Syndrome

JEADV Clinical Practice, EarlyView.
ABSTRACT Transporter associated with antigen presentation (TAP) deficiency syndrome (TDS) is a rare primary immunodeficiency (PID) characterised by a broad spectrum of clinical manifestations, with noninfectious cutaneous granulomas (CG) being a common feature.
A. Fernández‐Galván, M. Aparicio, P. Muñoz, J. Fulgencio‐Barbarín, N. D. Zurita, D. Arroyo‐Sánchez, O. Cabrera‐Marante, L. M. Allende, M. Llamas‐Velasco   +8 more
wiley   +1 more source

Cutaneous Vasculitis as a Covid‐19 Manifestation: A Cross‐Sectional Study With Detailed Histopathological Evaluation

JEADV Clinical Practice, EarlyView.
Multiple cutaneous manifestations have been linked with COVID‐19, including cutaneous vasculitis, ranging from mild or asymptomatic to fulminant. We conducted a comprehensive study investigating the cutaneous and histopathological manifestations of vasculitis in 33 patients with COVID‐19.
Reem Diab, Azadeh Rakhshan, Mohammad Shahidi Dadras, Sareh Salarinejad, Ali Kaddah, Zahra Razzaghi, Marwa Akhdar, Roxanna Sadoughifar, Fahimeh Abdollahimajd   +8 more
wiley   +1 more source

Comprehensive Transcriptomic and m6A Epitranscriptomic Analysis Reveals Colchicine-Induced Kidney Toxicity via DNA Damage and Autophagy in HK2 Cells

Toxins
Colchicine is commonly prescribed for inflammation and gout, but its nephrotoxicity and underlying mechanisms remain incompletely understood. The objective of this research was to clarify the association between m6A methylation modifications and ...
Kun Tian, Jiaxin Wen, Dongcheng Zhang, Jiaxuan Lin, Lixiang Weng, Lele Yang, Wei Zhao, Chutao Li, An Zhu   +8 more
doaj   +1 more source