Results 41 to 50 of about 45,519 (269)
Annals of the Rheumatic Diseases, 2020 Objectives The outbreak of COVID-19 posed the issue of urgently identifying treatment strategies. Colchicine was considered for this purpose based on well-recognised anti-inflammatory effects and potential antiviral properties.
M. Scarsi +27 more
semanticscholar +1 more source
Effects of Acute Colchicine Administration Prior to Percutaneous Coronary Intervention
Circulation. Cardiovascular Interventions, 2020 Supplemental Digital Content is available in the text. Background: Vascular injury and inflammation during percutaneous coronary intervention (PCI) are associated with increased risk of post-PCI adverse outcomes.
Binita Shah +10 more
semanticscholar +1 more source
Colchicine for the treatment of COVID-19.
Cochrane Database of Systematic Reviews, 2021 BACKGROUND The development of severe coronavirus disease 2019 (COVID-19) and poor clinical outcomes are associated with hyperinflammation and a complex dysregulation of the immune response.
A. Mikołajewska +11 more
semanticscholar +1 more source
The etiology and autopsy findings in Colchicine intoxication-related deaths
Medicine Science, 2016 Colchicine is a drug which has a very narrow therapeutic range. This drug has been commonly used for Familial Mediterranean Fever (FMF), Behcets disease, gout arthritis and acute pseudo gout attacks.
Servet Birgin Iritas +7 more
doaj +1 more source
Biosynthesis of Colchicine [PDF]
Nature, 1960 OF several proposals1–4 concerning the biogenesis of the alkaloid colchicine (5; R 1 = R 2 = Me), only that of Wenkert4 involves the intervention of an intact tropolone ring prior to formation of ring B.
openaire +2 more sources
Anti-inflammatory therapy for COVID-19 infection: the case for colchicine
Annals of the Rheumatic Diseases, 2020 The search for effective COVID-19 management strategies continues to evolve. Current understanding of SARS-CoV-2 mechanisms suggests a central role for exaggerated activation of the innate immune system as an important contributor to COVID-19 adverse ...
A. Reyes +6 more
semanticscholar +1 more source
Transcriptome analysis reveals plant response to colchicine treatment during on chromosome doubling
Scientific Reports, 2017 Colchicine was commonly used to artificially double chromosomes while the transcriptome changes in colchicine treated plants has rarely been characterized.
Kai Zhou +4 more
doaj +1 more source
Colchicine in COVID-19: an Old Drug, New Use
Current Pharmacology Reports, 2020 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, is a pandemic causing havoc globally. Currently, there are no Food and Drug Administration (FDA)-approved drugs to treat COVID-19.
N. Schlesinger +2 more
semanticscholar +1 more source
Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2021 Background Inflammation plays a pivotal role in coronary artery disease (CAD). The anti‐inflammatory drug colchicine seems to reduce ischemic events in patients with CAD. So far there is equipoise about its safety and impact on mortality.
T. Kofler +11 more
semanticscholar +1 more source
Future Science OA, 2021 Purpose: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI). Materials & methods: Ischemia/Reperfusion was induced in C57BL/6J male mice.
Fabien Huet +6 more
doaj +1 more source