Results 41 to 50 of about 77,446 (306)
Rekayasa, 2023 Pumpkin (Cucurbita moschene Duthene) is plant sources of food that has high nutrition content. Increasing the productivity of pumpkin can be done through programs, which is the ploidy manipulation technique, the technique using a mutagen, namely ...
Reza Prakoso Dwi Julianto +2 more
doaj +1 more source
Colchicine in COVID-19: an Old Drug, New Use
Current Pharmacology Reports, 2020 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, is a pandemic causing havoc globally. Currently, there are no Food and Drug Administration (FDA)-approved drugs to treat COVID-19.
N. Schlesinger +2 more
semanticscholar +1 more source
PLoS ONE, 2021 Objectives Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed. We hypothesized that colchicine, by counteracting proinflammatory pathways implicated in the uncontrolled inflammatory response of COVID-19 patients, reduces ...
L. Manenti +23 more
semanticscholar +1 more source
Why Woodward and Hoffmann? And Why 1965?**
The Chemical Record, Volume 23, Issue 1, January 2023., 2023 R. B. Woodward and Roald Hoffmann provided perfect intellectual and experiential synergy for their collaboration on orbital symmetry control of pericyclic reactions. This publication describes their idiosyncratic qualities and how perfectly they matched, at the right place and at the right time.
Jeffrey I. Seeman
wiley +1 more source
Future Science OA, 2021 Purpose: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI). Materials & methods: Ischemia/Reperfusion was induced in C57BL/6J male mice.
Fabien Huet +6 more
doaj +1 more source
Arthritis Research & Therapy, 2020 Background Colchicine is a widely used drug to treat inflammatory diseases. Due to its long historical use in medicine, controlled clinical trials have been small and there remains some caution with the use of this drug in patients with co-morbidities ...
S. Stewart +4 more
semanticscholar +1 more source
JAMA Network Open, 2021 Key Points Question Does colchicine prevent intubation and mortality in hospitalized patients with COVID-19 pneumonia? Findings In this randomized clinical trial of 1279 patients hospitalized with COVID-19, patients allocated to receive colchicine plus ...
R. Diaz +23 more
semanticscholar +1 more source
Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2021 Background Inflammation plays a pivotal role in coronary artery disease (CAD). The anti‐inflammatory drug colchicine seems to reduce ischemic events in patients with CAD. So far there is equipoise about its safety and impact on mortality.
T. Kofler +11 more
semanticscholar +1 more source
Kaohsiung Journal of Medical Sciences, 2015 Microtubules are an ideal target for anticancer drugs because of their essential role in mitosis. Colchicine is a microtubule destabilizer. Whether the clinically acceptable colchicine concentrations had anticancer effects on human cholangiocarcinoma ...
Chun-Chieh Wu +3 more
doaj +1 more source
Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations. [PDF]
PLoS ONE, 2016 Tubulin isotypes are found to play an important role in regulating microtubule dynamics. The isotype composition is also thought to contribute in the development of drug resistance as tubulin isotypes show differential binding affinities for various anti-
Bajarang Vasant Kumbhar +3 more
doaj +1 more source