Results 51 to 60 of about 3,581,165 (352)

Effect of Relief-hole Diameter on Die Elastic Deformation during Cold Precision Forging of Helical Gears [PDF]

, 2017
During cold precision forging of helical gears, the die experiences high forming pressure resulting in elastic deformation of the die, a main factor affecting dimensional accuracy of a formed gear.
Feng, W., Hua, L., Long, H., Lv, J., Wang, F.   +4 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Damage Simulation of Pre-Forming V-Neck Plates with Variations in Material Type, Time and Temperature Using the Taguchi Method

Journal of Mechanical Engineering Science and Technology, 2018
In metal forming, damage can be caused by several factors: load on the workpiece, initial heating temperature, and temperature due to the friction between the die and the material for pre-forming.
Avita Ayu Permanasari, Poppy Puspitasari, Kevin Valiant Cahya, Mahfud Ihsan   +3 more
doaj   +1 more source

An infrared-submillimeter study of star-forming regions selected by the ISOSS 170um survey

, 2008
Using the ISOPHOT Serendipity Survey (ISOSS) at 170um a sample of galactic star-forming regions exhibiting very cold dust temperatures (< 20 K) and high masses (> 100 M_sun) has been established.
Beuther, Beuther, Birkmann, Birkmann, Bogun, Brand, D. Lemke, Draine, Engelbracht, Evans, Fazio, Gordon, Holland, Indebetouw, Indebetouw, Kessler, Krause, Krause, Lemke, Low, M. Hennemann, Makovoz, McKee, Motte, O. Krause, Ossenkopf, Rathborne, Rathborne, Rawlings, Reach, Reach, Rieke, Robitaille, Robitaille, S. M. Birkmann, Sandell, Sault, Shepherd, Sridharan, Sridharan, Stickel, Werner, Whitney, Zinnecker   +43 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Cold thread Forming – the chipless alternative for high resistant internal threads

MATEC Web of Conferences, 2018
In the area of construction and mechanical engineering the designers and production engineers very often do have the task to produce high resistant connections with the possibility of assembling and de assembling parts in a wide range of different ...
Heiler Roland
doaj   +1 more source

Review of Contact and Dynamic Phenomena in Cold Roll Forming [PDF]

, 2006
This review reflects the state of the art in study of contact and dynamic phenomena occurring in cold roll forming. The importance of taking these phenomena into account is determined by significant machine time and tooling costs spent on worn out ...
Daniel, William J. T., Galakhar, Alexander S., Meehan, Paul A.   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A review on forming techniques for manufacturing lightweight complex—shaped aluminium panel components

International Journal of Lightweight Materials and Manufacture, 2018
Aluminium alloys are being increasingly utilised in the automotive and aerospace industries to reduce the weight of vehicles. Extensive research has been conducted to overcome the poor ductility of aluminium alloys at room temperature and improve ...
Kailun Zheng, Denis J. Politis, Liliang Wang, Jianguo Lin   +3 more
doaj   +1 more source

Method for Controlling Edge Wave Defects of Parts during Roll Forming of High-Strength Steel

Metals, 2021
Cold roll forming is suitable for sheet metal processing and can provide a new method for the production and processing of anti-collision beams for commercial vehicles. In order to accurately control the edge wave defects of the parts in the roll forming
Ce Liang, Sinan Li, Jicai Liang, Jiandong Li   +3 more
doaj   +1 more source