Results 41 to 50 of about 2,154,939 (308)
Barriers to adaptation to sea-level rise [PDF]
, 2013 Increasingly there is recognition from researchers and policy makers that there are legal, institutional and cultural barriers to climate change adaptation that will need to be addressed if we are able to adapt efficiently and equitably.
Elissa Waters +2 more
core
Benefits of controlled-release fertilizers for potato sustainable nitrogen management
Frontiers in Environmental ScienceThe evaluation of potato response to controlled-release fertilizers (CRFs), as a sole source of nitrogen (N) or as a blend with a soluble N source, is essential to 1) develop the best management recommendations for using CRFs in potato production and 2 ...
Huiling Xue +6 more
doaj +1 more source
Exercise performance in acute and chronic cold exposure
Journal of Physical Fitness and Sports Medicine, 2015 This review focuses on the suppression of physical performance in a cold environment and the underlying physiological mechanisms. There are many situations where humans have to perform physical activities in a cold environment.
Hitoshi Wakabayashi +2 more
doaj +1 more source
A Cold Limit to Adaptation in the Sea [PDF]
Trends in Ecology & Evolution, 2016 Temperature affects biological functions by altering reaction rates. Physiological rates usually double to treble for every 10 °C rise, and 1-4 fold encompasses normal biological functions. However, in polar marine species inhabiting temperatures around 0 °C many processes are slowed beyond the Arrhenius relationships for warmer water species.
openaire +3 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
AgronomyPotassium (K) fertilization is a promising strategy to alleviate drought-induced photosynthetic inhibition in potato. However, cultivar-specific responses remain poorly understood.
Dong Wang +6 more
doaj +1 more source
Exercise Does Not Prevent Thermoregulatory Adaptation to Cold Stress During the Winter Season [PDF]
운동과학PURPOSE Despite the growing need for recreation and work in cold environments, which often involve high levels of physical activity and significant body heat loss, studies investigating the impact of exercise during repeated cold exposure on cold ...
Dae-Hwan Kim +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Adaptation to cold antagonizes neurotensin-induced hypothermia in mice
, 1986 Intracerebrally-administered neurotensin produces a marked hypothermia in a variety of mammals. In this study, prior adaptation to a cold environment was found to significantly antagonize the hypothermia produced by intracisternally-administered ...
Prange, Arthur J +4 more
core +1 more source