Results 51 to 60 of about 2,154,939 (308)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Genomic Insights of Cryobacterium Isolated From Ice Core Reveal Genome Dynamics for Adaptation in Glacier

Frontiers in Microbiology, 2020
Glacier is the dominant cold habitat in terrestrial environments, providing a model ecosystem to explore extremophilic strategies and study early lives on Earth. The dominant form of life in glaciers is bacteria.
Yongqin Liu, Yongqin Liu, Yongqin Liu, Liang Shen, Liang Shen, Yonghui Zeng, Tingting Xing, Tingting Xing, Baiqing Xu, Baiqing Xu, Ninglian Wang, Ninglian Wang   +11 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cold adaptation mechanisms in microorganisms [PDF]

, 2011
On our planet there are vast areas, where the average temperature does not exceed 5 řC. They are also many places, where the temperature often drops below zero. Not every living organism is able to live in these conditions. The ability to survive in cold
Dřízhalová, Marie
core  

Alpine meadow degradation regulates soil microbial diversity via decreasing plant production on the Qinghai-Tibetan Plateau

Ecological Indicators
In recent decades, alpine meadows have experienced severe degradation owing to external disturbances. Although soil microorganisms are critical for ecosystem services, little is known about their responses to soil degradation and the potential patterns ...
Yu Sun, Xiujuan Zhang, Yongsheng Yang, Yuheng Zhang, Junbang Wang, Mingyang Zhang, Chu Wu, Junliang Zou, Huakun Zhou, Jiexia Li   +9 more
doaj   +1 more source

Histamine and Cold Adaptation

Experimental Biology and Medicine, 1963
SummaryRats exposed to cold (6°C) for one month show a very rapid and sustained increase in urinary histamine. At the end of this period animals develop a certain tolerance to histamine aerosols. This modification in histamine excretion in the cold possibly reflects mast cell changes and the decreased sensitivity to this amine in cold adapted animals ...
openaire   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Molecular basis of cold adaptation [PDF]

, 2002
peer reviewedCold-adapted, or psychrophilic, organisms are able to thrive at low temperatures in permanently cold environments, which in fact characterize the greatest proportion of our planet.
Georlette, D., D'Amico, Salvino, Feller, Georges, Meuwis, Marie-Alice, Gratia, E., Collins, T., Hoyoux, A., Gerday, Charles, Claverie, P.   +8 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source