Results 201 to 210 of about 115,795 (305)

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

The inherent defects of cold atmospheric plasma for the treatment of burns. [PDF]

Front Pharmacol
Li Y, Guan H, Fan G, Ma J.
europepmc   +1 more source

The Role of Interfacial Shear Strength in Composite Performance

Polymer Composites, EarlyView.
Plasma‐modified fibre interfaces: effects on interfacial shear strength and composite fracture behaviour. ABSTRACT This study investigates the role of interfacial shear strength (ISS) in governing the mechanical behavior of fiber‐reinforced composites through an experimental approach.
G. Scarselli, N. Murphy, D. Dowling, P. S. Rao, N. P. O’Dowd, A. Ivankovic   +5 more
wiley   +1 more source

In Vivo Immune Cell Responses and Long-Term Effects of Cold Atmospheric Plasma in the Upper Respiratory Tract. [PDF]

Int J Mol Sci
Arndt S, Unger P, Gebhardt L, Schober R, Berneburg M, Karrer S.   +5 more
europepmc   +1 more source

Cryostratigraphy of Rhythmic Segregated Ice in Colluvium and Implications for Permafrost Slope Stability

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT The amount and stratigraphic setting of ground ice in permafrost slopes is a key control on the style and magnitude of permafrost mass wasting. Understanding the spatial and stratigraphic variations in ground ice distribution on permafrost slopes is therefore a fundamental property in assessing the stability of permafrost hillslopes.
Joseph M. Young, Alejandro Alvarez, Duane Froese   +2 more
wiley   +1 more source

Cold Atmospheric Plasma Treatment of Zirconia to Improve Its Bond Strength and Longevity with Dental Cement. [PDF]

Materials (Basel)
Liao Y, Phan T, Yu Q.
europepmc   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

The Effects of Nanohydroxyapatite with and without Low-Power Laser and Cold Atmospheric Plasma on Enamel Remineralization: <i>in vitro</i> Study. [PDF]

J Dent (Shiraz)
Bakhtiary P, Gharavi M, Ebrahimi H, Salem K.   +3 more
europepmc   +1 more source

Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation

Small, EarlyView.
A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul, Cédric Bergerbit, Iulia Scarlat, Teodora Piskova, Vasudha Turuvekere Krishnamurthy, Aleksandra N. Kozyrina, Stacy Lok Sze Yam, Laura De Laporte, Jacopo Di Russo   +8 more
wiley   +1 more source

Electrochemical Detection of NO and Ca²⁺ during Cold Atmospheric Plasma Treatment of Acute Wounds: Sensor Selectivity and Stability in the Plasma-Bio-System. [PDF]

Plasma Chem Plasma Process
Thomas JE, Pattison K, Kumar S, Karkada G, Trosan D, Goodin A, Rainone J, Rananavare D, Miller V, Berthiaume F, Stapelmann K.   +10 more
europepmc   +1 more source