Results 111 to 120 of about 860,994 (301)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors
Nature CommunicationsContext-specific epigenetic dependencies, shaped by chromatin remodeling can create exploitable vulnerabilities for cancer therapies that are unique to tissue types and cellular identities.
Michael F. Ciccone +19 more
doaj +1 more source
EPJ Web of Conferences, 2012 The chemistry of cosmic diffuse gas as well as its astrophysical significance is discussed from the primordial gas to cold cores where stars can form.
Verstraete L.
doaj +1 more source
Regression Model to Predict the Higher Heating Value of Poultry Waste from Proximate Analysis
Resources, 2018 Improper land application of excess poultry waste (PW) causes environmental issues and other problems. Meanwhile there is an increasing trend of using PW as an alternative energy resource.
Xuejun Qian +3 more
doaj +1 more source
Cyclonic cold-core eddy in the eastern North Atlantic. II. Nutients, phytoplankton and bacteriaplankton [PDF]
, 1987 A cyclonic cold-core eddy in the Northeast Atlantic of about 100 km in diameter at the sea surface was investigated in May 1985, approximately 3 wk after it had separated from the Polar Front.
Lochte, Karin, Pfannkuche, Olaf
core
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Theoretical studies of ultra-cold environment chemistry
, 2022 Rates coefficients for elementary processes are modeled using theoretical ...
openaire +1 more source
The Deuterium Fractionation Timescale in Dense Cloud Cores: A Parameter Space Exploration
, 2015 The deuterium fraction [N$_2$D$^+$]/[N$_2$H$^+$], may provide information about the ages of dense, cold gas structures, important to compare with dynamical models of cloud core formation and evolution.
Caselli, Paola +4 more
core +3 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors
Nature Communications, 2019 Context-dependent inhibition of NMDA receptors has important therapeutic implications for treatment of neurological diseases. Here, the authors use structural biology and biophysics to describe the basis for pH-dependent inhibition for a class of ...
Michael C. Regan +8 more
doaj +1 more source