Results 121 to 130 of about 3,307,945 (309)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

A Pyrone Glucoside from Maerua angolensis Induces Caspase-Dependent Apoptosis and Targets AKT1, PARP-1, and Caspase-7 in Triple-Negative Breast Cancer

Biomolecules
Triple-negative breast cancer (TNBC) is an aggressive subtype lacking effective targeted therapies, highlighting the need for new anticancer agents. Natural products remain a valuable source of bioactive compounds with diverse mechanisms of action.
Jamila Aminu, Amina Jega Yusuf, Bor-Jang Hwang, Sonia Kamran, Nasiru Abdullahi, Adamu Jibril Alhassan, John Obadipe, Valerie Odero-Marah, Hajjagana Hamza, Abdullahi Ibrahim Uba, James Wachira, Jiangnan Peng   +11 more
doaj   +1 more source

Introducing Cosmic Chemistry

EPJ Web of Conferences, 2012
The chemistry of cosmic diffuse gas as well as its astrophysical significance is discussed from the primordial gas to cold cores where stars can form.
Verstraete L.
doaj   +1 more source

Regression Model to Predict the Higher Heating Value of Poultry Waste from Proximate Analysis

Resources, 2018
Improper land application of excess poultry waste (PW) causes environmental issues and other problems. Meanwhile there is an increasing trend of using PW as an alternative energy resource.
Xuejun Qian, Seong Lee, Ana-maria Soto, Guangming Chen   +3 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Chemistry and Biochemistry at Texas, 1990

, 1990
Table of Contents: The City and the Region (p. 1) -- The University (p. 3) -- The Department (p. 4) -- The Mallet Library (p. 5) -- X-Ray Diffraction Facility (p. 6) -- NMR Facility (p. 7) -- Mass Spectroscopy Facility (p. 8) -- Computer Facilities (p. 9)
Chemistry Department
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Making and Unmaking the Cold War in Museums [PDF]

To introduce “Cold War Museology” and a volume of new essays in this chapter, we develop what we propose to be core themes of the subject. Our aim is to establish the Cold War as a key topic in museum studies, both in its own right, but also in terms of ...
Alberti, Samuel J M M, Douthwaite, Jessica, Nehring, Holger   +2 more
core   +1 more source

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors

Nature Communications, 2019
Context-dependent inhibition of NMDA receptors has important therapeutic implications for treatment of neurological diseases. Here, the authors use structural biology and biophysics to describe the basis for pH-dependent inhibition for a class of ...
Michael C. Regan, Zongjian Zhu, Hongjie Yuan, Scott J. Myers, Dave S. Menaldino, Yesim A. Tahirovic, Dennis C. Liotta, Stephen F. Traynelis, Hiro Furukawa   +8 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source