Results 91 to 100 of about 3,307,945 (309)
eLife, 2016 TP53 truncating mutations are common in human tumors and are thought to give rise to p53-null alleles. Here, we show that TP53 exon-6 truncating mutations occur at higher than expected frequencies and produce proteins that lack canonical p53 tumor ...
Nitin H Shirole +11 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Synthesis and characterisation of first row transition metal complexes of functionalized 1,2,4-benzothiadiazines [PDF]
, 2014 The authors thank the EPSRC (E.R.C.), NSERC (M.P.; J.M.R.; E.Z.-C.) and the Canada Research Chairs program (M.P.; J.M.R.) for financial supportReaction of the novel ligand 3-(2′-pyridyl)-benzo-1,2,4-thiadiazine (L) with the transition metal chloride ...
Hayward, John J. +19 more
core +1 more source
MoleculesGemcitabine is a widely used antimetabolite drug of pyrimidine structure, which can exist as a free-base molecular form (Gem). The encapsulated forms of medicinal drugs are of interest for delayed and local drug release.
Sheriff Umar, Alexander Samokhvalov
doaj +1 more source
Cold chemistry with electronically excited Ca+ Coulomb crystals
The Journal of Chemical Physics, 2010 Rate constants for chemical reactions of laser-cooled Ca+ ions and neutral polar molecules (CH3F, CH2F2, or CH3Cl) have been measured at low collision energies (⟨Ecoll⟩/kB=5–243 K). Low kinetic energy ensembles of C40a+ ions are prepared through Doppler laser cooling to form “Coulomb crystals” in which the ions form a latticelike arrangement in the ...
Gingell, A +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Rapid Whole Blood Bioassays using Microwave-Accelerated Metal-Enhanced Fluorescence
Nano Biomedicine and Engineering, 2010 The proof-of-principle demonstration of rapid whole blood bioassays based on microwave-accelerated metal-enhanced fluorescence (MAMEF) method using silver nanoparticle-deposited surfaces is presented.
Kadir Aslan
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Applications of Coulomb crystals in cold chemistry
, 2010 This thesis describes the study of a range of ion-molecule reactions at very low collision energies using a newly developed experimental technique which involves the reaction of velocity-selected beams of translationally cold neutral molecules with very low kinetic energy ion ensembles.
Gingell, A, Gingell, Alexander David
openaire +2 more sources