Results 71 to 80 of about 860,994 (301)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

ARXPS-studies ofcˆ-axis textured YBa2Cu3Ox-films [PDF]

, 1988
YBa2Cu3Ox sputter deposited cold on MgO grows in O2 annealing epitaxially to a transparent, superconducting film with Tc 80K. The unscraped surfaces of these films are smooth showing XPS lines changing with photoelectron take-off angle.
Halbritter, J., Hauser, B., Mathes, H.-J., Rogalla, H., Walk, P.   +4 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

(E)-2-{[(Furan-2-ylmethyl)imino]methyl}-4-nitrophenol

Acta Crystallographica Section E, 2014
In the title compound, C12H10N2O4, the furan-2-ylmethyl group is disordered over two sets of sites, with refined occupancies of 0.858 (3) and 0.143 (3). In the major component of disorder, the dihedral angle between the furan and benzene rings is 63.1 (2)
Yousef Hijji, Samira Azemati, Ray J. Butcher, Jerry P. Jasinski   +3 more
doaj   +1 more source

Antibody-directed extracellular proximity biotinylation reveals that Contactin-1 regulates axo-axonic innervation of axon initial segments

Nature Communications, 2023
Axon initial segment (AIS) cell surface proteins mediate key biological processes in neurons including action potential initiation and axo-axonic synapse formation. However, few AIS cell surface proteins have been identified.
Yuki Ogawa, Brian C. Lim, Shanu George, Juan A. Oses-Prieto, Joshua M. Rasband, Yael Eshed-Eisenbach, Hamdan Hamdan, Supna Nair, Francesco Boato, Elior Peles, Alma L. Burlingame, Linda Van Aelst, Matthew N. Rasband   +12 more
doaj   +1 more source

Cold chemistry with electronically excited Ca+ Coulomb crystals

The Journal of Chemical Physics, 2010
Rate constants for chemical reactions of laser-cooled Ca+ ions and neutral polar molecules (CH3F, CH2F2, or CH3Cl) have been measured at low collision energies (⟨Ecoll⟩/kB=5–243 K). Low kinetic energy ensembles of C40a+ ions are prepared through Doppler laser cooling to form “Coulomb crystals” in which the ions form a latticelike arrangement in the ...
Gingell, A, Bell, M, Oldham, J, Softley, T, Harvey, J   +4 more
openaire   +3 more sources

Champagne Flutes and Brandy Snifters: Modelling Protostellar Outflow-Cloud Chemical Interfaces

, 2014
A rich variety of molecular species has now been observed towards hot cores in star forming regions and in the interstellar medium. An increasing body of evidence from millimetre interferometers suggests that many of these form at the interfaces between ...
Rawlings, Jonathan M. C., Redman, Matt P., Rollins, Richard P., Williams, David A.   +3 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Chemical modeling of Infrared Dark Clouds: the Role of Surface Chemistry

, 2012
We simulate the chemistry of infrared dark clouds (IRDCs) with a model in which the physical conditions are homogeneous and time-independent. The chemistry is solved as a function of time with three networks: one purely gas-phase, one that includes ...
A. I. Vasyunin, Aikawa, Battersby, Bergin, Beuther, Brogan, Brown, Carey, Carey, Caselli, Cyganowski, Devine, Egan, Eric Herbst, Foster, Garrod, Gibson, H. Linz, Jackson, Katz, Keto, Perault, Ragan, Ragan, Rathborne, Rodgers, Sakai, Sakai, Sakai, T. Vasyunina, Vasyunin, Vasyunin, Wakelam   +32 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source