Results 61 to 70 of about 860,994 (301)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Cold ion chemistry within Coulomb crystals [PDF]

Molecular Physics, 2019
ABSTRACTCoulomb crystals are ordered structures of spatially-localised ions, held within an ion trap and exhibiting very low translational temperatures. The many advantages of studying the spectroscopic, kinetic and dynamic properties of gas phase ions in Coulomb crystals – such as the ability to manipulate and detect single ions under ultrahigh vacuum
openaire   +2 more sources

Note: High density pulsed molecular beam for cold ion chemistry [PDF]

Review of Scientific Instruments, 2014
A recent expansion of cold and ultracold molecule applications has led to renewed focus on molecular species preparation under ultrahigh vacuum conditions. Meanwhile, molecular beams have been used to study gas phase chemical reactions for decades. In this paper, we describe an apparatus that uses pulsed molecular beam technology to achieve high local ...
M. G. Kokish, V. Rajagopal, J. P. Marler, B. C. Odom   +3 more
openaire   +3 more sources

The Novel ''Controlled Intermediate Nuclear Fusion'' and its Possible Industrial Realization as Predicted by Hadronic Mechanics and Chemistry [PDF]

, 2005
In this note, we propose, apparently for the first time, a new type of controlled nuclear fusion called "intermediate" because occurring at energies intermediate between those of the ''cold'' and ''hot'' fusions, and propose a specific industrial ...
Santilli, Ruggero Maria
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Astrochemistry of dust, ice and gas: introduction and overview

, 2014
A brief introduction and overview of the astrochemistry of dust, ice and gas and their interplay is presented, aimed at non-specialists. The importance of basic chemical physics studies of critical reactions is illustrated through a number of recent ...
van Dishoeck, Ewine F.
core   +1 more source

A coarse-grained protein model in a water-like solvent [PDF]

, 2013
Simulations employing an explicit atom description of proteins in solvent can be computationally expensive. On the other hand, coarse-grained protein models in implicit solvent miss essential features of the hydrophobic effect, especially its temperature
Buldyrev, Sergey V., Debenedetti, Pablo G., Kumar, Sanat K., Rossky, Peter J., Sharma, Sumit, Stanley, Harry Eugene   +5 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Core repulsion effects in alkali trimers

, 2009
The present paper is related to a talk presented during the Symposium on Coherent Control and Ultracold Chemistry held during the Sixth Congress of the International Society for Theoretical Chemical Physics (ISTCP-VI, July 2008).
Aymar, Aymar, Aymar, Baranov, Barnett, Bartenstein, Bethlem, Bloch, Bourdel, Boys, Chin, Chin, Chin, Cho, Coker, Colavecchia, Cvitaš, Cvitaš, Cvitaš, Danzl, Deiglmayr, Deiglmayr, DeMille, DeMille, DeMille, Donley, Durand, Durand, Foucrault, Gerlich, Gilijamse, Gorál, Greiner, Hampel, Herbig, Higgins, Hinds, Hudson, Hudson, Hudson, Huron, Hutson, Hutson, Iron, Jaksch, Jeung, Jochim, Jones, Karr, Kawall, Kotochigova, Kozlov, Krems, Köhler, Lang, Li, Li, Li, Magnier, Magnier, Mark, Metz, Müller, Ni, Pavolini, Quéméner, Quéméner, Quéméner, Rabl, Rabl, Ravaine, Regal, Schiller, Simoni, Soldán, Soldán, Soldán, Spiegelmann, Staanum, Stwalley, van de Meerakker, van Veldhoven, Viteau, Xie, Zahzam, Zelevinsky, Zwierlein, Zwierlein, Čížek   +88 more
core   +2 more sources