Results 51 to 60 of about 678,119 (336)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Strongly-interacting ultralight millicharged particles
Physics Letters B, 2021 We consider the implications of an ultra-light fermionic dark matter candidate that carries baryon number. This naturally arises if dark matter has a small charge under standard model baryon number whilst having an asymmetry equal and opposite to that in
Stephon Alexander +2 more
doaj +1 more source
Particle Physics Approach to Dark Matter
, 2006 We review the main proposals of particle physics for the composition of the cold dark matter in the universe. Strong axion contribution to cold dark matter is not favored if the Peccei-Quinn field emerges with non-zero value at the end of inflation and ...
A. Djouadi +64 more
core +4 more sources
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Search for Neutrino Mass and Dark Matter in Underground Experiments [PDF]
, 2002 Search for the neutrino mass and for cold dark matter in the Universe are at present two of the most exciting fields of particle physics and cosmology.
Klapdor-Kleingrothaus, H. V.
core +2 more sources
Microlensing and Halo Cold Dark Matter
Physical Review Letters, 1995 We discuss the implications of the more than 50 microlensing events seen by the EROS, MACHO, and OGLE collaborations for the composition of the halo of our galaxy. The event rates indicate that the halo mass fraction in MACHO's is less than 30\%, consistent with expectations for a universe whose primary component is cold dark matter.
Gates, Evalyn I. +2 more
openaire +3 more sources
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
C-19 and Hot, Wide Star Streams
The Astrophysical JournalThe C-19 star stream has the abundance characteristics of an unusually metal-poor globular cluster but kinematically is uncharacteristically hot and wide for a cluster stream, having a line-of-sight velocity dispersion of 7 ± 2 km s ^−1 and a 1 σ width
Raymond G. Carlberg +7 more
doaj +1 more source
Light neutralino dark matter in U(1)XSSM
Nuclear Physics B, 2021 The U(1)X extension of the minimal supersymmetric standard model (MSSM) is called as U(1)XSSM with the local gauge group SU(3)C×SU(2)L×U(1)Y×U(1)X. U(1)XSSM has three singlet Higgs superfields beyond MSSM.
Shu-Min Zhao +5 more
doaj +1 more source
Superweakly Interacting Massive Particles [PDF]
, 2003 We investigate a new class of dark matter: superweakly-interacting massive particles (superWIMPs). As with conventional WIMPs, superWIMPs appear in well-motivated particle theories with naturally the correct relic density.
Feng, Jonathan L. +2 more
core +2 more sources