Results 71 to 80 of about 2,207,306 (351)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Kolmogorov cosmic microwave background sky

, 2009
A new map of the sky representing the degree of randomness in the cosmic microwave background (CMB) temperature has been obtained. The map based on estimation of the Kolmogorov stochasticity parameter clearly distinguishes the contribution of the ...
A. A. Kocharyan, A. E. Allahverdyan, A. L. Kashin, Arnold, Copi, E. Poghosian, Eriksen, G. Yegorian, Gurzadyan, Gurzadyan, Gurzadyan, Gurzadyan, Gurzadyan, Gurzadyan, Górski, H. G. Khachatryan, H. Kuloghlian, Inoue, Kolmogorov, Kovac, Rudnick, S. Mirzoyan, Smoot, T. Ghahramanyan, V. G. Gurzadyan, Vielva, Wiltshire   +26 more
core   +1 more source

Water Content and Superconductivity in Na0.3CoO2*yH2O [PDF]

, 2003
We report here the correlation between the water content and superconductivity in Na0.3CoO2*yH2O under the influences of elevated temperature and cold compression.
Baikalov, A., Chu, C. W., Cmaidalka, J., Meng, R. L., Xue, Y. Y.   +4 more
core   +3 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Transient Receptor Potential Melastatin 8 (TRPM8)-Based Mechanisms Underlie Both the Cold Temperature-Induced Inflammatory Reactions and the Synergistic Effect of Cigarette Smoke in Human Bronchial Epithelial (16HBE) Cells

Frontiers in Physiology, 2019
Transient receptor potential melastatin 8 (TRPM8) is a major receptor of cold environment. Recently, we found that cigarette smoke extract (CSE) upregulated TRPM8 mRNA and protein expression in bronchial tissues that made them more sensitive to cold ...
Jing Wang, Gang Yang, Minchao Li, Xiangdong Zhou   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Potential Impacts of Meteorological Variables on Acute Ischemic Stroke Onset

Risk Management and Healthcare Policy, 2020
Xuemei Qi,1 Zhongyan Wang,2 Xiaoshuang Xia,1 Juanjuan Xue,1 Yumeng Gu,1 Suqin Han,3 Lin Wang,2 Xin Li,1,* Sean X Leng4,* 1Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, People’s Republic of China; 2Department ...
Qi X, Wang Z, Xia X, Xue J, Gu Y, Han S, Wang L, Li X, Leng SX   +8 more
doaj  

Kinetics of indirect excitons in the optically-induced exciton trap

, 2007
We report on the kinetics of a low-temperature gas of indirect excitons in the optically-induced exciton trap. The excitons in the region of laser excitation are found to rapidly -- within 4 ns -- cool to the lattice temperature T = 1.4 K, while the ...
A. C. Gossard, A. L. Ivanov, A. T. Hammack, L. Mouchliadis, L. V. Butov, L. V. Keldysh, L. V. Keldysh, P. C. M. Christianen   +7 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source