Results 91 to 100 of about 457,403 (331)

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

Advanced Science, EarlyView.
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li, Lei Zhu, Zhaohuai Li, Yihan Zhang, Genxian Zhang, Xuening Peng, Dongting Wu, Qi Jiang, Rong Wang, Renbing Jia, Song Guo Zheng, Wenru Su   +11 more
wiley   +1 more source

Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity

Health and Quality of Life Outcomes, 2008
Background Ulcerative colitis disease activity is determined by measuring symptoms and signs. Our aim was to determine which symptom domains are frequent and responsive to change in the evaluation of disease activity, which are those defined by three ...
Wang Sijian, Zimmermann Ellen M, Dave Maneesh, Wren Patricia A, Khan Tahira, Waljee Akbar K, Joyce Joel C, Zhu Ji, Higgins Peter DR   +8 more
doaj   +1 more source

Recent trends in the epidemiology of inflammatory bowel diseases: up or down? [PDF]

, 2006
Inflammatory bowel disease (IBD) is traditionally considered to be common in the Western world, and its incidence has sharply increased since the early 1950s.
Lakatos, Péter László
core   +1 more source

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Nature Communications, 2019
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients ...
Y. Haberman, Rebekah A. Karns, P. Dexheimer, M. Schirmer, Judith Somekh, I. Jurickova, T. Braun, Elizabeth A. Novak, Laura E. Bauman, M. Collins, A. Mo, M. Rosen, Erin Bonkowski, Nathan M Gotman, Alison Marquis, Mason Nistel, P. Rufo, S. Baker, Cary G. Sauer, J. Markowitz, M. Pfefferkorn, J. Rosh, B. Boyle, D. Mack, R. Baldassano, Sapana R. Shah, N. LeLeiko, M. Heyman, A. Grifiths, A. Patel, J. Noe, B. Aronow, S. Kugathasan, T. Walters, G. Gibson, S. Thomas, K. Mollen, S. Shen-Orr, C. Huttenhower, R. Xavier, J. Hyams, L. Denson   +41 more
semanticscholar   +1 more source

Carrier‐Free Nanocapsule with Dual‐Target Capacity for Synergistically Restoring Inflammatory Microenvironment and Microbiota Dysbiosis in Colitis

Advanced Science, EarlyView.
This manuscript presents a carrier‐free nanomedicine PCNPs@PEG‐Man with dual‐targeting for IBD. It resists harsh intestinal conditions, reduces oxidative stress, enhances drug uptake and retention, modulates inflammation, and reshapes gut microbiota, offering a safe and effective IBD therapy.
Yingjie Chen, Yuhan Gao, Kaiyuan Huo, Zhaofan Jin, Wenchao Wang, Xingjie Zan, Yanlong Liu, Limeng Zhu, Jianfeng Yang   +8 more
wiley   +1 more source

Systems biology in inflammatory bowel diseases [PDF]

, 2014
Purpose of review: Ulcerative colitis (UC) and Crohn’s Disease (CD) are the two predominant types of inflammatory bowel disease (IBD), affecting over 1.4 million individuals in the US.
Iliopoulos, D, Koukos, G, Polytarchou, C
core   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease [PDF]

, 2010
Nitrite and nitrate are frequently used surrogate markers of nitric oxide (NO) production. Using rat models of acute and chronic DSS-induced colitis we examined the applicability of these and other NO-related metabolites, in tissues and blood, for the ...
Ahn, Alexandra B. Milsom, Andoh, Angelo, Aoi, Billiar, Bryan, Bryan, Brüne, Buffinton, Butler, Calvert, Carr, Cheng, Chris Andry, Collins, Cooper, D. Neil Granger, Danese, Danese, de Kok, Dijkstra, Eiserich, Feelisch, Finkel, Fumito Saijo, Godkin, Grisham, Guevara, Guihot, Guzy, Herulf, Ikeda, Jourd’heuil, Juan Rodriguez, Kapsoritakis, Kihara, Kimura, Kimura, Kleinbongard, Kolios, Krawisz, Krieglstein, Lundberg, Lundberg, Marina Ivanovic, Martin Feelisch, May, Miehsler, Murthy, Nathan S. Bryan, Nikolaus, Okayasu, Onderdonk, Osman, Ostanin, Pearson, Quera, Rachmilewitz, Reynolds, Rius, Roediger, Rousseaux, Rumi, Schopfer, Selena M. Bauer, Singer, Solem, Stucchi, Stuehr, Talbot, Taniguchi, Taylor, Terada, Thorsten Vowinkel, Togawa, Tsikas, van Faassen, Velayos, Vowinkel, Wang, Whiteman   +81 more
core   +1 more source

Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis.

Journal of Crohn's & Colitis, 2019
BACKGROUND AND AIMS In ulcerative colitis [UC], mucosal damage occurs in areas that are infiltrated with neutrophils. The antimicrobial function of neutrophils relies in part on the formation of extracellular web-like structures, named neutrophil ...
V. Dinallo, I. Marafini, D. Di Fusco, F. Laudisi, E. Franzè, A. Di Grazia, M. Figliuzzi, F. Caprioli, C. Stolfi, I. Monteleone, G. Monteleone   +10 more
semanticscholar   +1 more source

ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7

Advanced Science, EarlyView.
Histone lysine crotonylation (Kcr) is a highly conserved posttranslational modification implicated with crucial biological processes. This study reveals that ACSS2‐mediated H4K12cr upregulated CLDN7 transcription to strengthen intestinal epithelial barrier.
Ming Yuan, Shaopeng Chen, Zhensen Lin, Runfeng Yu, Kang Chao, Shubiao Ye, Qing Li, Haoxian Ke, Chi Zhang, Junfeng Huang, Guanzhan Liang, Tuo Hu, Xiang Gao, Ping Lan, Xianrui Wu   +14 more
wiley   +1 more source