Results 121 to 130 of about 471,997 (328)

Lifestyle Issues in Inflammatory Bowel Disease – Smoking

Canadian Journal of Gastroenterology, 1994
During the pa t decade, smoking habit has been identified as a major exogenous factor in inflammatory bowel disease (IBD). It is associated not only with the development of the disease but al o with the clinical course in established disease.
Cecilia Benoni
doaj   +1 more source

Protective Effect of Curcumin on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Obese Mice

Korean Journal of Clinical Laboratory Science, 2022
Ulcerative colitis is a disease that causes inflammation in the mucosal or submucosal layer of the colon. Previous studies have reported that obesity increases the prevalence of ulcerative colitis and aggravates the progression.
Ho Park
doaj   +1 more source

Clinical performance of an infliximab rapid quantification assay [PDF]

, 2017
Background: Therapeutic drug monitoring (TDM)-based algorithms can be used to guide infliximab (IFX) adjustments in inflammatory bowel disease (IBD) patients.
Afonso, Joana, Andrade, Patrícia, Caldeira, Paulo, Carneiro, Fátima, Carvalho, Diana, Coelho, Rosa, Dias, Cláudia Camila, Geboes, Karel, Gonçalves, Ana Rita, Gonçalves, Raquel, Lago, Paula, Lopes, Joanne, Lopes, Susana, Magro, Fernando, Meira, Tania, Ministro, Paula, Ramos, Jaime, Rosa, Isadora, Soares, João-Bruno, Sousa, Helena Tavares, Sousa, Paula, Vieira, Ana Isabel   +21 more
core   +2 more sources

Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis.

Journal of Crohn's & Colitis, 2019
BACKGROUND AND AIMS In ulcerative colitis [UC], mucosal damage occurs in areas that are infiltrated with neutrophils. The antimicrobial function of neutrophils relies in part on the formation of extracellular web-like structures, named neutrophil ...
V. Dinallo, I. Marafini, D. Di Fusco, F. Laudisi, E. Franzè, A. Di Grazia, M. Figliuzzi, F. Caprioli, C. Stolfi, I. Monteleone, G. Monteleone   +10 more
semanticscholar   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

A programme for risk assessment and minimisation of progressive multifocal leukoencephalopathy developed for vedolizumab clinical trials [PDF]

, 2018
Introduction Over the past decade, the potential for drug-associated progressive multifocal leukoencephalopathy (PML) has become an increasingly important consideration in certain drug development programmes, particularly those of immunomodulatory ...
Berger, Joseph R, Clifford, David B, Fox, Irving, Lev, Michael H, Major, Eugene, McAuliffe, Megan, Milch, Catherine, Parikh, Asit, Patti, Mark, Provenzale, James M, Sankoh, Serap, Shick, Jesse, Stephens, Kristin   +12 more
core   +3 more sources

Ulcerative colitis in infancy

Saudi Journal of Gastroenterology, 2011
Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder of colon. Frequency of UC is gradually increasing over few years worldwide. Prevalence is 35 to 100/100,000 people in USA, 1% of them are infants. UC develops in a genetically predisposed individual with altered intestinal immune response. An eight-month-old girl presented with loose
Md Rukunuzzaman, A. S. M. Bazlul Karim
openaire   +3 more sources

Performance of a Deep Learning Model vs Human Reviewers in Grading Endoscopic Disease Severity of Patients With Ulcerative Colitis

JAMA Network Open, 2019
Key Points Question What is the agreement of automatically determined endoscopic severity of ulcerative colitis using deep learning models compared with expert human reviewers? Findings In this diagnostic study including colonoscopy data from 3082 adults,
R. Stidham, Wenshuo Liu, S. Bishu, Michael D. Rice, P. Higgins, Ji Zhu, B. Nallamothu, A. Waljee   +7 more
semanticscholar   +1 more source

RPSLearner: A Novel Approach Based on Random Projection and Deep Stacking Learning for Categorizing Non‐Small Cell Lung Cancer

Advanced Intelligent Systems, EarlyView.
Identifying non‐small cell lung cancer (NSCLC) subtypes is essential for precision cancer treatment. Conventional methods are laborious, or time‐consuming. To address these concerns, RPSLearner is proposed, which combines random projection and stacking ensemble learning for accurate NSCLC subtyping. RPSLearner outperforms state‐of‐the‐art approaches in
Xinchao Wu, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Gut mucosal virome alterations in ulcerative colitis

Gut, 2019
Objective The pathogenesis of UC relates to gut microbiota dysbiosis. We postulate that alterations in the viral community populating the intestinal mucosa play an important role in UC pathogenesis.
T. Zuo, Xiao-juan Lu, Yu Zhang, C. Cheung, S. Lam, Fen Zhang, Whitney Tang, J. Ching, R. Zhao, P. Chan, J. Sung, Jun Yu, F. Chan, Q. Cao, J. Sheng, S. Ng   +15 more
semanticscholar   +1 more source