Results 161 to 170 of about 467,445 (327)

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8+ T Cell Clones

Arthritis &Rheumatology, EarlyView.
Objective Psoriatic arthritis (PsA) is an HLA class I–associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T cell phenotype and clonality.
Lucy E. Durham, Frances Humby, Nora Ng, Roman Laddach, Elizabeth H. Gray, Sarah E. Ryan, Kathryn J. A. Steel, Rosie Ross, Giovanni A. M. Povoleri, Rosamond Nuamah, Kathy Fung, Athul Menon Kallayil, Pawan Dhami, Bruce W. Kirkham, Leonie S. Taams   +14 more
wiley   +1 more source

AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis.

Gastroenterology, 2020
J. Feuerstein, K. Isaacs, Yecheskel Schneider, S. Siddique, Y. Falck-Ytter, Siddharth Singh   +5 more
semanticscholar   +1 more source

Clinical Significance of Gut Microbiota Community Types for Long‐term Response to Fecal Microbiota Transplantation in Patients with Psoriatic Arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Fecal microbiota transplantation (FMT) holds promises as a beneficial supplement to methotrexate in patients with psoriatic arthritis (PsA). We therefore investigated how gut bacterial signatures in patients and donor strain engraftment associated with long‐term response to FMT.
Panpan Qin, Maja S. Kragsnaes, Dorte K. Holm, Hans Christian Horn, Anna Christine Nilsson, Jens Kjeldsen, Karsten Kristiansen, Torkell Ellingsen   +7 more
wiley   +1 more source

Significance of autoimune reactions to pancreatic juice in Crohn`s disease [PDF]

, 1988
Goebell, Harald, Otte, M., Scriba, Peter Christian, Stöcker, W.   +3 more
core   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

British Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen, Fariha Balouch, Claire Reilly, Christopher Burgess, Peter Lewindon   +4 more
wiley   +1 more source

The persistence of chronic opioid use in patients with inflammatory bowel disease—A nationwide cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pain is common in patients with Crohn's disease (CD) and ulcerative colitis (UC), and a substantial proportion develop chronic opioid use (COU). We examined the persistence of COU over time and identified factors predicting persistent use. Methods This nationwide Danish cohort study included patients with an initial period of COU (definition: ≥3 ...
Bente Mertz Nørgård, Caroline Theilgaard Thorarinsson, Jan Nielsen, Mette Louise Andersen, Jens Kjeldsen, Torben Knudsen, Rahul S. Dalal   +6 more
wiley   +1 more source

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Electrochemical Breath Sensors in Medical Diagnostics: Emerging Trends and Future Directions

ChemElectroChem, EarlyView.
Electrochemical breath sensors (EBSs) are emerging as powerful tools for noninvasive health diagnostics. This perspective highlights recent advances in EBS technologies, explores their potential in mental health monitoring via gut‐derived volatile organic compounds, and outlines future directions for achieving sensitive, selective, and clinically ...
Natalie E. Strom, Courtney J. Weber, Olja Simoska   +2 more
wiley   +1 more source

Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9

Cytoskeleton, EarlyView.
ABSTRACT The unbranched actin filaments in mammalian cells are usually composed of co‐polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin filaments in an isoform‐specific, non‐redundant manner.
Jeff Hook, Edna C. Hardeman, Peter W. Gunning   +2 more
wiley   +1 more source