Results 11 to 20 of about 471,997 (328)

Integrated bioinformatics and network pharmacology to identify the therapeutic target and molecular mechanisms of Huangqin decoction on ulcerative Colitis

Scientific Reports, 2022
Huangqin decoction (HQD) is a Traditional Chinese Medicine formula for ulcerative colitis. However, the pharmacology and molecular mechanism of HQD on ulcerative colitis is still unclear.
Yi Wu, Xinqiao Liu, Guiwei Li
doaj   +2 more sources

Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis.

New England Journal of Medicine, 2021
BACKGROUND Ozanimod, a selective sphingosine-1-phosphate receptor modulator, is under investigation for the treatment of inflammatory bowel disease. METHODS We conducted a phase 3, multicenter, randomized, double-blind, placebo-controlled trial of ...
W. Sandborn, B. Feagan, G. D'Haens, D. Wolf, I. Jovanović, S. Hanauer, Subrata Ghosh, A. Petersen, S. Hua, Ji Hwan Lee, L. Charles, D. Chitkara, K. Usiskin, J. Colombel, L. Laine, S. Danese   +15 more
semanticscholar   +1 more source

Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells

Nature Communications, 2022
Cholesterol sulfate, produced by hydroxysteroid sulfotransferase 2B1 (SULT2B1), is highly abundant in the intestine. Herein, we study the functional role and underlying intestinal epithelial repair mechanisms of cholesterol sulfate in ulcerative colitis.
Dongke Xu, Ruijun Ma, Yi Ju, Xiaowei Song, Baolin Niu, Wenting Hong, Rong Wang, Qin Yang, Zhiwei Zhao, Yuchen Zhang, Yufan Zheng, Q. Bai, Mingfang Lv, Ning Sun, Xiaobo Li   +14 more
semanticscholar   +1 more source

Ozanimod: A Review in Ulcerative Colitis

Drugs, 2022
Ozanimod (Zeposia®) is the first sphingosine-1-phosphate receptor (S1PR) modulator to be approved for the treatment of adults with moderately to severely active ulcerative colitis in the USA, and in adults with moderately to severely active ulcerative ...
J. Paik
semanticscholar   +1 more source

Ulcerative colitis: an update.

Clinical medicine (London), 2021
Ulcerative colitis is a relapsing and remitting disease that is increasing in incidence and prevalence. Management aims to achieve rapid resolution of symptoms, mucosal healing and improvement in a patient's quality of life.
J. Segal, J. LeBlanc, A. Hart
semanticscholar   +1 more source

Detection of Campylobacter concisus and other Campylobacter species in colonic biopsies from adults with ulcerative colitis [PDF]

, 2011
Peer reviewedPublisher ...
Berry, Susan H, El-Omar, Emad M, Hansen, Richard, Hold, Georgina L, Mukhopadhya, Indrani, Thomson, John M   +5 more
core   +14 more sources

Acute pulmonary embolism following corticosteroid administration in acute severe ulcerative colitis with gastrointestinal bleeding: A case report

Frontiers in Cardiovascular Medicine, 2022
BackgroundUlcerative colitis often leads to gastrointestinal bleeding and venous thromboembolism (VTE). At present, there is no clear conclusion about anticoagulant therapy for these patients.
Xuhan Liu, Xia Peng, Chunyan Rong, Weihua Zhang   +3 more
doaj   +1 more source

Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. [PDF]

, 2020
Oxidative stress and chronic inflammation play critical roles in the pathogenesis of ulcerative colitis (UC) and inflammatory bowel diseases (IBD). A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium ...
Farzaneh, Ted, Ichii, Hirohito, Lau, Hien, Li, Shiri, Robles, Lourdes, Stamos, Michael J, Takasu, Chie, Vaziri, Nosratola D, Vo, Kelly   +8 more
core   +2 more sources

Prevalence of inflammatory bowel disease in the Australian general practice population: A cross-sectional study.

PLoS ONE, 2021
The burden of inflammatory bowel disease (IBD) in Australia is increasing but national data about the current prevalence are limited. We aimed to estimate the prevalence of IBD (including Crohn's disease, ulcerative colitis and unspecified IBD) as well ...
Doreen Busingye, Allan Pollack, Kendal Chidwick   +2 more
doaj   +1 more source

Colitis due to Cytomegalovirus and Herpes Simplex Type 2 as a Complication of a First Presentation of Inflammatory Bowel Disease

GE: Portuguese Journal of Gastroenterology, 2021
Introduction: The first presentation of ulcerative colitis may be an acute flare in about 15% of patients, requiring hospital admission. In acute severe steroid-refractory ulcerative colitis, cytomegalovirus (CMV) should be sought because it is a ...
Tiago Leal, Bruno Arroja, Dalila Costa, Carla Ferreira, João Bruno Soares, Raquel Gonçalves   +5 more
doaj   +1 more source