On the Evaluation of Surrogate Markers in Real World Data Settings [PDF]
arXiv, 2021 Shortcomings of randomized clinical trials are pronounced in urgent health crises, when rapid identification of effective treatments is critical. Leveraging short-term surrogates in real-world data (RWD) can guide policymakers evaluating new treatments.
arxiv
Deep Bayesian Active-Learning-to-Rank for Endoscopic Image Data [PDF]
arXiv, 2022 Automatic image-based disease severity estimation generally uses discrete (i.e., quantized) severity labels. Annotating discrete labels is often difficult due to the images with ambiguous severity. An easier alternative is to use relative annotation, which compares the severity level between image pairs.
arxiv
Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls [PDF]
, 2013 Background: Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival.
De Vos, Martine +4 more
core +2 more sources
Smoking and nicotine in inflammatory bowel disease: good or bad for cytokines?
Mediators of Inflammation, 1998 Smoking has either a beneficial or harmful effect on the course and recurrence of ulcerative colitis and Crohn's disease respectively. Transdermal application of nicotine had similar effects in ulcerative colitis and therefore was considered to be an ...
F. J. Zijlstra
doaj +1 more source
ULCERATIVE COLITIS IN CHILDREN [PDF]
Romanian Journal of Pediatrics, 2009 Chronic nonspecific ulcerative colitis remaine a disease of unkown etiology, although much new information continues to be gleaned from basic research and clinical trials. In most instances, ulcerative colitis respond to medical therapy.
Florea Iordăchescu
doaj +1 more source
Gastrointestinal Mucosal Problems Classification with Deep Learning [PDF]
arXiv, 2023 Gastrointestinal mucosal changes can cause cancers after some years and early diagnosing them can be very useful to prevent cancers and early treatment. In this article, 8 classes of mucosal changes and anatomical landmarks including Polyps, Ulcerative Colitis, Esophagitis, Normal Z-Line, Normal Pylorus, Normal Cecum, Dyed Lifted Polyps, and Dyed ...
arxiv
CMV in the gut: a critical review of CMV detection in the immunocompetent host with colitis. [PDF]
, 2015 As scientific techniques for the detection of cytomegalovirus (CMV) improve, we are able to detect small amounts of CMV in the mucosal wall. As clinicians, we are unsure how to interpret the results of this novel test.
Goodman, AL +4 more
core +1 more source
Soluble human Suppression of Tumorigenicity 2 is associated with endoscopic activity in patients with moderate-to-severe ulcerative colitis treated with golimumab [PDF]
, 2019 Suppressor of Tumorigenicity 2 (ST2) is an IL33 receptor detected in the mucosa and serum of ulcerative colitis (UC) patients. We evaluated soluble ST2 (sST2) as a surrogate biomarker of disease outcome and therapeutic response, in moderate-to-severe UC ...
Diogo Branquinho +22 more
core +3 more sources
Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa. A proof-of-concept study [PDF]
, 2018 AIM To investigate the adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model.
Corleto, Vito Domenico +6 more
core +1 more source
Frontiers in MedicineUlcerative colitis is a common digestive disorder worldwide, with increasing incidence in recent years. It is an urgent problem to be solved, as it seriously affects and threatens the health and life of the global population.
Hang Ning +4 more
doaj +1 more source