Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management
Frontiers in Medicine, 2022 In recent years, immunotherapy has become an important pillar of cancer treatment, with high response rates regardless of tumor histology or baseline mutations, sometime in patients without any alternative of treatment.
Virginia Robles-Alonso +3 more
doaj +1 more source
Order-Guided Disentangled Representation Learning for Ulcerative Colitis Classification with Limited Labels [PDF]
, 2021 Ulcerative colitis (UC) classification, which is an important task for endoscopic diagnosis, involves two main difficulties. First, endoscopic images with the annotation about UC (positive or negative) are usually limited. Second, they show a large variability in their appearance due to the location in the colon.
arxiv +1 more source
Infliximab for induction and maintenance therapy for ulcerative colitis.
New England Journal of Medicine, 2005 BACKGROUND Infliximab, a chimeric monoclonal antibody directed against tumor necrosis factor alpha, is an established treatment for Crohn's disease but not ulcerative colitis. METHODS Two randomized, double-blind, placebo-controlled studies--the Active
P. Rutgeerts +13 more
semanticscholar +1 more source
Oral iron exacerbates colitis and influences the intestinal microbiome [PDF]
, 2018 Inflammatory bowel disease (IBD) is associated with anaemia and oral iron replacement to correct this can be problematic, intensifying inflammation and tissue damage.
Burkitt, M D +10 more
core +3 more sources
Topical and Systemic Cannabidiol Improves Trinitrobenzene Sulfonic Acid Colitis in Mice [PDF]
, 2012 Background/Aims: Compounds of Cannabis sativa are known to exert anti-inflammatory properties, some of them without inducing psychotropic side effects. Cannabidiol (CBD) is such a side effect-free phytocannabinoid that improves chemically induced colitis
Ashton CH +31 more
core +1 more source
Nod2 Deficiency in mice is Associated with Microbiota Variation Favouring the Expansion of mucosal CD4+ LAP+ Regulatory Cells [PDF]
, 2018 Nucleotide-binding Oligomerization Domain-2 (NOD2) mutations are associated with an increased risk to develop Crohn's Disease. In previous studies, we have shown that Nod2-/- mice manifest increased proportion of Lamina Propria (LP) CD4+ LAP+ Foxp3 ...
Boirivant, M. +9 more
core +3 more sources
Development of Mucosal PNAd+ and MAdCAM-1+ Venules during Disease Course in Ulcerative Colitis
Cells, 2020 PNAd and MAdCAM-1 addressins on venules are of importance in T-cell homing and potential therapeutic targets in ulcerative colitis (UC). Normally, PNAd+ high endothelial venules (HEVs) are only present in lymphoid organs, whereas small numbers of MAdCAM ...
Britt Roosenboom +10 more
doaj +1 more source
ACG Clinical Guideline: Ulcerative Colitis in Adults
American Journal of Gastroenterology, 2019 Ulcerative colitis (UC) is an idiopathic inflammatory disorder. These guidelines indicate the preferred approach to the management of adults with UC and represent the official practice recommendations of the American College of Gastroenterology.
D. Rubin +4 more
semanticscholar +1 more source
Ulcerative colitis: an update.
Clinical medicine (London), 2021 Ulcerative colitis is a relapsing and remitting disease that is increasing in incidence and prevalence. Management aims to achieve rapid resolution of symptoms, mucosal healing and improvement in a patient's quality of life.
J. Segal, J. LeBlanc, A. Hart
semanticscholar +1 more source
BMC Medical Ethics, 2019 Background Much like academic-industry partnerships, industry financial support of patient advocacy organizations (PAOs) has become very common in recent years.
Orna Ehrlich +3 more
doaj +1 more source