Results 41 to 50 of about 672,024 (402)

Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by NLRP3 Activation

Microbiology spectrum, 2021
The gut microbiota and host immune response interaction influences the progression of intestinal inflammatory disease. As a well-recognized next-generation probiotic, Akkermansia muciniphila has been proved to play a crucial role in the progression of ...
Siwen Qu, Lina Fan, Yadong Qi, Chaochao Xu, Yingying Hu, Shujie Chen, Wei Liu, Weili Liu, Jianmin Si   +8 more
semanticscholar   +1 more source

Unveiling Colitis: A Journey through the Dextran Sodium Sulfate-induced Model.

Inflammatory Bowel Diseases
Animal models of inflammatory bowel disease (IBD) are valuable tools for investigating the factors involved in IBD pathogenesis and evaluating new therapeutic options.
Chunhua Yang, D. Merlin
semanticscholar   +1 more source

PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. [PDF]

, 2012
Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (
Achkar, Jean-Paul, Balschun, Tobias, Brand, Stephan, Czamara, Darina, Diegelmann, Julia, Duerr, Richard H., Franke, Andre, Glas, Jürgen, Kamboh, M. Ilyas, Müller-Myhsok, Bertram, Olszak, Torsten, Pasciuto, Giulia, Seiderer, Julia, Wetzke, Martin, Wolf, Christiane   +14 more
core   +9 more sources

An Etiologic Profile of Anemia in 405 Geriatric Patients

Anemia, 2014
Background. Anemia is a common condition in the elderly and a significant risk factor for increased morbidity and mortality, reducing not only functional capacity and mobility but also quality of life.
Tabea Geisel, Julia Martin, Bettina Schulze, Roland Schaefer, Matthias Bach, Garth Virgin, Jürgen Stein   +6 more
doaj   +1 more source

Interferon-Gamma–Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor–Colitis

Gastroenterology, 2021
Background & Aims The pathogenesis of immune checkpoint inhibitor (ICI)–colitis remains incompletely understood. We sought to identify key cellular drivers of ICI-colitis and their similarities to idiopathic ulcerative colitis, and to determine potential
S. Sasson, S. Slevin, V. Cheung, I. Nassiri, A. Olsson-Brown, E. Fryer, R. Ferreira, D. Trzupek, T. Gupta, L. Al‐Hillawi, Mari-Lenna Issaias, A. Easton, L. Campo, Michael E. B. FitzPatrick, Joss Adams, M. Chitnis, A. Protheroe, M. Tuthill, N. Coupe, A. Simmons, M. Payne, M. Middleton, S. Travis, B. Fairfax, P. Klenerman, O. Brain   +25 more
semanticscholar   +1 more source

Efficacy and Safety of Intravenous Ferric Carboxymaltose in Geriatric Inpatients at a German Tertiary University Teaching Hospital: A Retrospective Observational Cohort Study of Clinical Practice

Anemia, 2015
Current iron supplementation practice in geriatric patients is erratic and lacks evidence-based recommendations. Despite potential benefits in this population, intravenous iron supplementation is often withheld due to concerns regarding pharmacy expense,
Matthias Bach, Tabea Geisel, Julia Martin, Bettina Schulze, Roland Schaefer, Garth Virgin, Juergen Stein   +6 more
doaj   +1 more source

Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis

Theranostics, 2020
Background: Gut microbiota, which plays a crucial role in inflammatory bowel diseases (IBD), might have therapeutic benefits for ulcerative colitis or Crohn's disease. Targeting gut microbiota represents a new treatment strategy for IBD patients.
Jiawei Wu, Zhonghong Wei, P. Cheng, C. Qian, Fang-Yuan Xu, Yu Yang, Aiyun Wang, Wenxing Chen, Zhiguang Sun, Yin Lu   +9 more
semanticscholar   +1 more source

Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect

Microorganisms, 2021
Colonization by the benign tapeworm, Hymenolepis diminuta, has been associated with a reduction in intestinal inflammation and changes in bacterial microbiota. However, the role of microbiota in the tapeworm anti-inflammatory effect is not yet clear, and
Milan Jirků, Zuzana Lhotská, Lucia Frgelecová, Oldřiška Kadlecová, Klára Judita Petrželková, Evan Morien, Kateřina Jirků-Pomajbíková   +6 more
doaj   +1 more source

Krill oil, vitamin D and Lactobacillus reuteri cooperate to reduce gut inflammation [PDF]

, 2018
Current research into original therapies to treat intestinal inflammation is focusing on no-drug therapies. KLD is a mixture of krill oil (KO), probiotic Lactobacillus reuteri (LR), and vitamin D (VitD3).
Cesi, V., Colantoni, E., Costanzo, M., Cucchiara, S., Leter, B., Negroni, A., Palone, F., Pierdomenico, M., Stronati, L., Vitali, R.   +9 more
core   +1 more source

Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome, and immune responses in colitis.

Nature Materials, 2019
While conventional approaches for inflammatory bowel diseases mainly focus on suppressing hyperactive immune responses, it remains unclear how to address disrupted intestinal barriers, dysbiosis of the gut commensal microbiota and dysregulated mucosal ...
Yonghyun Lee, Kohei Sugihara, Merritt G. Gillilland, S. Jon, N. Kamada, J. Moon   +5 more
semanticscholar   +1 more source